Evaluation of neutrophil-to-lymphocyte ratio and hematologic parameters in patients with Graves’ disease

Abstract

AIM: While the ratio of neutrophil-to-lymphocyte (NLR) increases with infl ammation, its importance in Graves' disease is not clear. The aim of this study was to evaluate NLR, a marker of chronic infl ammmation, in Graves' disease. METHODS: 86 Graves' patients (37 before treatment,49 euthyroid patients after treatment) and 112 controls were enrolled. Hematologic parameters, thyroid function tests, age and gender were recorded. NLRs were calculated. Firstly, groups were composed as Graves' group (Group1) and participants without thyroid disorder as control group (Group2). Secondly, Graves' patients before treatment were considered as Group1a, euthyroid Graves' patients after antithyroid treatment were considered as Group1b. These groups were compared with each other in terms of descriptive data and hematological parameters. RESULTS: Lymphocyte, monocyte, platelet, free T3, and free T4 levels were signifi cantly higher in Graves' group than the controls. TSH and NLR were signifi cantly lower in Graves' group Graves' than the controls. Differences among group1a and group1b for monocyte (p = 0.013), for basophil (p= 0.002), for platelet (p = 0.029), and for NLR (p = 0.029) were statistically signifi cant. CONCLUSION: Unlike other infl ammatory diseases, in Graves' disease; hematological parameters may not give information about infl ammatory state of the disease. Therefore, NLR should be evaluated with other serum infl ammatory markers in Graves' disease (Tab. 2, Fig. 1, Ref. 26).

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Relation to Clinical Parameters and Smoking Status in Patients with Graves’ Orbitopathy—Novel Insight into Old Tests

“…In accordance to previous data, we proved that there were no statistically significant differences in basophil and eosinophil counts in GD patients with and without GO compared to controls [ 44 , 48 ]. Some reports suggested increased percentage of eosinophil in peripheral blood in GD patients compared to healthy individuals, but it might be associated with concomitant Th-2-predominant disorders [ 48 , 49 , 50 ].…”

“…What is more, it was observed that activated T cells release cytokines, such as tumor necrosis factor α (TNF-α), interleukin 1 β (IL-1β), interleukin 6 (IL-6), and interleukin (IL-17), which results in the increased production and recruitment of neutrophils and macrophages. This hypothesis partially explains neutrophilia, increased monocyte counts, and MLR values in the course of GD which were observed in our research [ 5 , 12 , 28 , 29 , 44 , 46 ].…”

“…Similar results were obtained by Celik et al, who revealed that both WBC, neutrophil, lymphocyte counts and NLR values were significantly higher in the group of patients with GO compared with the controls [ 28 ]. Contrary to the above-mentioned results, there are reports showing no significant differences in NLR values between GD patients as compared with healthy subjects [ 44 ]. Surprisingly, Dağdeviren et al noted that neutrophil levels and NLR values were statistically lower in hyperthyroid patients with GD compared with non-GD hyperthyroid group and healthy individuals.…”

Peripheral inflammatory biomarkers as predictors of recurrence in surgically-treated anogenital condylomata acuminata patients

“…Even a quick and simple search in the literature reveals many examples of the use of PIBs to reflect the systemic status of both infection and inflammation and their use as a surrogate for a pathway to end-organ disease, mainly in the immunocompromised population, including cancer, PLWH and cirrhotic patients. [7][8][9][10] Recently, in a large cohort of unselected cancer patients, NLP was found to have a predictive value for recurrence and overall survival. 10 Evaluated together with the results of another study conducted in colorectal cancer patients, reflecting NLR as a systemic inflammatory response marker suitable to define the risk stratification of cancer patients, it is possible to consider PIBs as tumor-associated inflammatory response parameters in terms of relapses and recurrences in neoplastic processes.…”

The Effect of Inflammation on the Formation of Thyroid Nodules

“…Patients with diabetes, who are considered to have low-grade inflammation in vivo , show increased WBC, NE, and LY [ 16 ]. Patients with Graves' disease, a chronic autoimmune disease, have higher LY and Mo in blood [ 17 ]. Thus, WBC, NE, LY, and Mo can suggest the systemic inflammation in subjects without obvious infection.…”