Neutrophil gelatinase-associated lipocalin (NGAL) for the prediction of acute kidney injury in chronic kidney disease patients treated with primary percutaneous coronary intervention

Abstract

Highlights Chronic kidney disease (CKD) patients may demonstrate elevated NGAL levels reflecting chronic impairment condition. We evaluated plasma NGAL level for identification of AKI superimposed on CKD vs. “de novo” AKI among (STEMI) patients undergoing primary PCI. NGAL is a useful tool for the identification of patients with CKD in high risk for AKI following primary PCI. However, Different cutoff values of plasma NGAL for “de novo” AKI and AKI superimposed on CKD may be necessary for Table 1 , Table 2 , Table 3 diagnosis.

Comparison of Neutrophil Gelatinase-associated Lipocalin and Renal Resistive Index as Acute Kidney Injury Predictor in Critically Ill Patients at ICU H. Adam Malik Hospital Medan

“…This is because NGAL is a glycoprotein that stored in mature neutrophil granules and found to be released by renal tubular cells after acute tubular damage. Laboratory examination can detect an increase in NGAL several hours after the occurrence of tubular damage [1], [3], [5].…”

“…Laboratory tests can detect an increase in NGAL several hours after tubular damage and are reported to predict AKI earlier than serum creatinine [1], [4], [8]. Apart from NGAL, Renal resistive index (RRI) also been reported to be a good early marker of AKI.…”

New Insights into Molecular Mechanisms of Chronic Kidney Disease

“…Thus, NGAL is a marker of tubular damage [ 55 ]. NGAL production from tubular cells may reflect the entity of active renal damage that underlies the chronic impairment condition [ 57 ]. NGAL can be produced by kidney tubular cells in response to different types of injuries.…”

Review Neutrophil Gelatinase-Associated Lipocalin (NGAL): Perannya sebagai Biomarker pada Kerusakan Ginjal Akut

“…Penegakan diagnosis kerusakan ginjal akut dengan cepat diperlukan juga untuk penderita gangguan ginjal lain seperti gagal ginjal kronis, untuk mengetahui keberhasilan dan manajemen terapi yang sedang dilakukan, bagaimana prognosis kerusakan ginjal serta apakah pasien membutuhkan terapi transplantasi ginjal atau tetap terapi yang sedang dijalani [26]. Plasma NGAL sebagai biomarker paling sensitif untuk perkembangan kerusakan ginjal akut yang dapat mengetahui kebutuhan jangka pendek dan panjang untuk transplantasi ginjal [27].…”

“…Penelitian menyebutkan diagnostik NGAL serum/plasma memiliki akurasi yang baik [28,29]. Pemantauan biomarker dengan cepat dan sensitif diperlukan agar tiap kondisi ginjal dan tingkat kerusakan dapat dipantau semaksimal mungkin, untuk mencegah prognosis kerusakan ginjal semakin memburuk [26].…”