Neutrophil Formylpeptide Receptor Single Nucleotide Polymorphism 348T&gt;C in Aggressive Periodontitis

Maney, Pooja; Emecen, Pinar; Mills, John; Walters, John D.

doi:10.1902/jop.2009.080225

Cited by 24 publications

(15 citation statements)

References 24 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it is unclear why individuals with the 348T/T genotype exhibit a lower PMN chemotactic response to fMLF, it is possible that 348T reduces the number of FPRs through a posttranscriptional regulatory mechanism. Consistent with this possibility, we recently reported that the mRNA associated with the haplotype 348T.568A exhibited higher free energy (lower stability) and a different secondary structure than that predicted for 348C.568A, which could potentially decrease mRNA stability and decrease translational efficiency 5,23 . Moreover, within five haplotype pairs differing only at 348T>C, the predicted secondary mRNA structures of haplotypes containing 348T were all associated with higher free energy (and lower stability) than those containing 348C.…”

Section: Discussionmentioning

confidence: 59%

“…A commercially available kit ‖‖ was used to isolate genomic DNA from whole blood obtained from 37 cases and 38 controls. FPR1 SNP 348T>C and other coding region SNPs were detected by PCR amplification and sequencing of a 439–base pair (bp) fragment of FPR1 as previously described 23 . To detect 5′ SNPs, validated primer sets were used to amplify four fragments (500, 264, 188, and 783 bp) spanning ∼10 kb of the FPR1 5′ region 15 .…”

Section: Methodsmentioning

confidence: 99%

“…Our previous work showed that African Americans who are homozygous for the 348T variant of the synonymous SNP 348T>C have a significantly increased risk for developing AgP, and the homozygous 348T genotype seems to occur only in individuals with AgP 23 . Although 348T>C does not code for a change in the amino acid structure, synonymous coding region SNPs are occasionally associated with 5′ SNPs in promoter or enhancer regions that can alter gene expression.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Formylpeptide Receptor Single Nucleotide Polymorphism 348T>C and Its Relationship to Polymorphonuclear Leukocyte Chemotaxis in Aggressive Periodontitis

Maney

Walters

2009

Journal of Periodontology

Self Cite

View full text Add to dashboard Cite

Background-Aggressive periodontitis (AgP) is associated with impaired polymorphonuclear leukocyte (PMN) chemotaxis toward bacterial N-formylpeptides. Formylpeptide receptors (FPRs) play a major role in guiding PMNs to infection sites. Previous work revealed a significant association between FPR1 single nucleotide polymorphism (SNP) 348T>C and AgP in African Americans. We tested the hypothesis that 348T impairs PMN chemotaxis by decreasing FPR mRNA expression, thereby increasing susceptibility to AgP.

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Formylpeptide Receptor Single Nucleotide Polymorphism 348T>C and Its Relationship to Polymorphonuclear Leukocyte Chemotaxis in Aggressive Periodontitis

Maney

Walters

2009

Journal of Periodontology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The FPR1 gene was also examined in several studies; this gene encodes the high‐affinity N‐formyl peptide receptor, which is involved in attracting monocytes to sites of infection and mediating degranulation. These processes are thought to be abnormal in AgP, and thus genes controlling the function of this process are logical candidates . The first reported study was by Gwinn et al; however, the SNPs described by this group could not be identified/replicated by Zhang et al and we found that most of the reported primer sequences did not map to the FPR1 gene.…”

Section: Candidate Gene Studies In Aggressive Periodontitismentioning

confidence: 61%

Genetic polymorphisms and periodontal disease in populations of African descent: A review

Gonçalves

Harris

Elmariah

et al. 2017

J of Periodontal Research

View full text Add to dashboard Cite

Aggressive periodontitis is a rare but rapidly progressing form of periodontal disease that usually affects otherwise systemically healthy individuals, at a young age. It usually affects first molars and incisors, which are usually lost if treatment is not properly and early rendered. Although of low prevalence, it affects individuals of African descent at a higher prevalence, and usually multiple members within the same family. Several studies have been performed in the attempt to evaluate specific single nucleotide polymorphisms (SNPs) that could be associated with this disease. To the best of our knowledge, the present article provides the first review of the literature focusing on studies that evaluated SNPs in patients of African descent with aggressive periodontitis. Several SNPs have been evaluated in different genes according to their role in the pathogenesis of the disease, with positive and negative associations (such as IL1, FCGR3B, FPR1, LTF, CYBA, GLT6D1, TLR4) with both the localized and generalized forms of aggressive periodontitis. Given the complexity of periodontitis, the difficulty in gathering large cohorts diagnosed with this rare form of disease, and the fact that candidate gene studies may only determine part of the genetic risk of a disease, the search for specific SNPs associated with aggressive periodontitis seems to be a long one, most likely to result in the combination of multiple SNPs, in multiple genes.

show abstract

“…IL-10 promoter polymorphisms at positions −1082 G-A, −819C-T, and −590C-A [44] and FPR348 T-C gene polymorphism in African-American people [45] are potential risk indicators for GAP. It is said that Fc gamma RIIIb-NA2 allele and Fc gamma RIIIb-NA2/NA2 genotype, composite genotype FcaRIIIb-NA2/NA2, FCgammaRIIIa-H/H131 [46], and FCgamma polymorphisms [47] may lead to aggressive periodontitis.…”

Section: Il-4-590 T/t Il-4-34 T/t Genotype Il-6-174gmentioning

confidence: 99%

Oral and Periodontal Diseases in Consanguineous Marriages

Çalışır¹

2017

Insights Into Various Aspects of Oral Health

View full text Add to dashboard Cite

Periodontitis is deined as an inlammatory disease of supporting tissues of teeth characterized by progressive destruction of the periodontal ligament and alveolar bone. Periodontal manifestations of these genetic disorders or syndromes, such as familial and cyclic neutropenias, granulomatous disease, agranulocytosis, Langerhans' cell disease, glycogen storage disease, hypophosphatasia, leucocyte adhesion deiciency, and Papillon-Lefèvre, Chédiak-Higashi, Cohen, Ehlers-Danlos, Marfan, Down, Haim-Munk, and Kindlers syndromes, imitate some types of periodontal diseases. Most of these syndromes have autosomal-recessive characterization and can be seen commonly in consanguineous marriages. Therefore, consanguineous marriages have generally been accepted as having important detrimental efects on ofspring. There is a lot of genetic research about consanguineous marriage and its detrimental efects on ofspring. Although consanguineous marriages are common in the world, the relationship with oral and periodontal diseases has not been thoroughly investigated. We do not have enough of an understanding of the efects of consanguineous marriage on oral and periodontal diseases. In this chapter, previous studies in the literature related to this subject will be investigated and evaluated, and then this research will be related to oral and periodontal diseases. Therefore, this chapter will guide further research. The aim of this chapter is to show the relation between consanguineous marriages and oral-periodontal diseases.

show abstract

Neutrophil Formylpeptide Receptor Single Nucleotide Polymorphism 348T>C in Aggressive Periodontitis

Cited by 24 publications

References 24 publications

Formylpeptide Receptor Single Nucleotide Polymorphism 348T>C and Its Relationship to Polymorphonuclear Leukocyte Chemotaxis in Aggressive Periodontitis

Formylpeptide Receptor Single Nucleotide Polymorphism 348T>C and Its Relationship to Polymorphonuclear Leukocyte Chemotaxis in Aggressive Periodontitis

Genetic polymorphisms and periodontal disease in populations of African descent: A review

Oral and Periodontal Diseases in Consanguineous Marriages

Contact Info

Product

Resources

About