Oral and Periodontal Diseases in Consanguineous Marriages

Abstract

Periodontitis is deined as an inlammatory disease of supporting tissues of teeth characterized by progressive destruction of the periodontal ligament and alveolar bone. Periodontal manifestations of these genetic disorders or syndromes, such as familial and cyclic neutropenias, granulomatous disease, agranulocytosis, Langerhans' cell disease, glycogen storage disease, hypophosphatasia, leucocyte adhesion deiciency, and Papillon-Lefèvre, Chédiak-Higashi, Cohen, Ehlers-Danlos, Marfan, Down, Haim-Munk, and Kindlers syndromes, imitate some types of periodontal diseases. Most of these syndromes have autosomal-recessive characterization and can be seen commonly in consanguineous marriages. Therefore, consanguineous marriages have generally been accepted as having important detrimental efects on ofspring. There is a lot of genetic research about consanguineous marriage and its detrimental efects on ofspring. Although consanguineous marriages are common in the world, the relationship with oral and periodontal diseases has not been thoroughly investigated. We do not have enough of an understanding of the efects of consanguineous marriage on oral and periodontal diseases. In this chapter, previous studies in the literature related to this subject will be investigated and evaluated, and then this research will be related to oral and periodontal diseases. Therefore, this chapter will guide further research. The aim of this chapter is to show the relation between consanguineous marriages and oral-periodontal diseases.

Consanguineous marriage as a key indicator of isolated congenital dental anomaly among South Indian population – A cross-sectional study

“…Pedigree analysis studies with genetic expression analysis using methods like In situ -hybridization expression technique,[ 24 ] whole-exome sequencing[ 25 ] focusing on the influence of molecular pattern on dental evolution correlated with morphological variations can help in characterization of these isolated anomalies. Although in this study individuals with syndromes or known congenital diseases were excluded to eliminate the possibility of congenital anomalies arising from these syndrome associated etiology, it should not be underestimated that studies have also shown many syndromes such as Haim-Munk[ 26 ] and Papillon–Lefèvre syndromes,[ 27 ] Ehler-Danlos syndrome,[ 28 ] Chediak–Higashi syndrome[ 29 ] presenting with oral manifestations are closely related to consanguineous marriage.…”

Consanguineous Marriages and Dental Anomalies: A Cross-Sectional Analytical Study

“…The sky-scraping practices of consanguineous marriages in our community are attributable to social practices, ignorance of the general population about associated adversaries, and reluctance to discuss such momentous issues. A matter of concern is that Pakistan ranked 149 th among 179 countries in 2015 on the Maternal Mortality Ratio Index, which is somehow pertinent to consanguineous marriages and congenital malformations as well [ 19 , 20 ]. Perveen et al conducted a similar study in tertiary care institute at Karachi and the lion's share turned out to be neural tube defects widely attributable to consanguinity [ 21 ].…”