Neurotropic activity of organogermanium compounds

Abstract

Neurotropic activity of several classes of organogermanium compounds (namely germatranes, germanols, germsesquioxanes, germyladamantanes, germylamides, germylimides and germylsubstituted amines, imines and hydroxamic acids) and their synthesis are reviewed.

Bromination of silatranyl‐, germatranyl‐, silyl‐, and germyl‐phenylacetylenes

“…A solution of bromine (0.05 mol) in 30 ml of CCl 4 was added dropwise to a solution of phenylacetylene (0.05 mol) in 30 ml of chloroform. Stirring of the reaction mixture for 3-6 h at room temperature was accompanied with gradual disappearance of the red color of bromine.…”

“…Among them metallatranes of the group 14 elements have been investigated rather in detail by the present time [1][2][3][4][5].…”

In vitro anti-leishmanial activities of germatranyl and Silicon incorporated diorganotin derivatives: Synthesis and spectroscopic properties

“…The compounds (1)(2)(3)(4)(5)(6)(7)(8) are quite stable in moist-air and their physico-analytical data are presented in Table I. The molecular structures of the synthesized compounds were established on the basis of the data obtained by elemental analyses and spectroscopic studies like multinuclear ( 1 H, 13 Table II.…”

“…For figure and more details see elsewhere [19]. The CH 2 group of benzyl moiety resonated at 2.5 ppm as a singlet for compounds (5)(6)(7)(8). Phenyl group of the benzyl moiety and phenyl attached to germanium overlap in aromatic region and pose some difficulty to be differentiated.…”

“…Organotin carboxylates are the most ubiquitous owing to their important biocidal activity [3,4]. Toxicological and pharmaco-kinetic studies of germanium revealed its low mammalian toxicity, after these informations, developments were oriented towards its biological applications as chemotherapeutic agents [5][6][7]. Germatranes have been examined for their neurotropic, antitumour, and radioprotective properties [8].…”