Neurotic depression: approaches to treatment

Volel, B. A.; Sorokina, O. Yu.

doi:10.17116/jnevro20191191269

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Механизмы развития депрессии связаны с многообразием предрасполагающих факторов и патогенетических процессов, что приводит к отсутствию единой теории развития. На сегодняшний день одним из ведущих патогенетических звеньев развития депрессии рассматриваются нарушения механизмов нейроиммунных взаимодействий [1][2][3][4][5][6][7][8]. При депрессии установлена повышенная активность моноцитарно -макрофагального звена иммунитета, высокий уровень экспрессии провоспалительных генов, что, в свою очередь, способствует дисбалансу цитокинового профиля с преобладанием провоспалительных цитокинов, которые опосредуют поведенческие и нейрохимические изменения при депрессии, приводя к нарушениям со стороны процессов нейропластичности, нейрогенеза и апоптоза [9,10].…”

Section: Discussionunclassified

Effect of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly-Pro on the level of pro- and anti-inflammatory cytokines in conditions of stress-induced depression

Yasenyavskaya

2023

jour

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Depression, being a heterogeneous disorder, is one of the most pressing problems in medicine, due to its high prevalence and the development of severe consequences, both medical and social. Currently, there is an urgent need to study the pathophysiological pathways that determine the development of depression in order to identify targets for the development of innovative multi-targeted drugs.Objective: to study the effect of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly-Pro on the level of pro- and anti-inflammatory cytokines in conditions of stress-induced depression.Materials and methods. The experiment was carried out on non-linear male rats 6 months old. age, in the amount of 50 individuals. A depressive-like state was modeled by providing constant sensory contact in rats and daily confrontations for 20 days, forming submissive and aggressive types of behavior.Results. It has been established that His-Phe-Arg-Trp-Pro-Gly-Pro in conditions of stress-induced depression helps restore the cytokine profile, reducing the level of proinflammatory cytokines (IL-1β, IL-6) and increasing the level of anti-inflammatory cytokines (IL-4 , IL-10).Conclusion. The results obtained allow us to consider stress-induced depression as an immune-mediated condition, which determines the need to develop new therapeutic and preventive methods taking into account immunological etiological and pathogenetic mechanisms. Analysis of key cytokines of neuroimmune interactions (IL-1β, IL-4, IL-6, IL-10) in animals exposed to a stress factor that induces the development of depression under the influence of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly- Pro showed that one of the ways to realize the action of this substance with a neuropeptide structure is to restore cytokine regulation.

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Section: Discussionunclassified

Effect of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly-Pro on the level of pro- and anti-inflammatory cytokines in conditions of stress-induced depression

Yasenyavskaya

2023

jour

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Recent approaches to the diagnosis and therapy of monopolar depression

Petelin,

Volel’

2023

Z. nevrol. psikhiatr. im. S.S. Korsakova

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The role of stressful traumatic events, personality traits and psychiatric disorders in the formation of chronic pain syndromes

Petelin,

Anpilogova,

Tolokonin

et al. 2024

Neurology bulletin

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BACKGROUND: Chronic pain syndrome is a highly prevalent condition that negatively affects the ability to work and quality of life, as well as worsening the prognosis of the disease and increasing the risk of early death. One of the most important scientific and practical medical tasks is the identification of risk factors for the transition of acute pain to chronic pain, which in the future will allow to develop mechanisms for preventing the development of chronic pain. It has been established that various psychological and psychopathological factors, in particular, personality traits and mental disorders, psychotraumatic events, make a significant contribution to the perpetuation of pain, but these data require clarification. AIM: To determine the contribution of stressful events, personality profile and comorbid psychiatric disorders to the formation of chronic pain syndromes. MATERIALS AND METHODS: The study included 105 patients aged 18 to 70 years with unexplained somatic or neurological pain syndrome that existed for more than 6 months and served as a reason for hospitalization. All patients underwent clinical-anamnestic and psychometric examination, statistical processing of the results was performed using SPSS Statistics v22. RESULTS: In the course of the study, 4 groups of patients with psychiatric disorders comorbid with chronic pain were formed: 1 — chronic pain within the framework of prolonged reaction to stress\exhaustion disorder, 42 observations (12 men, 30 women); 2 — chronic pain within the framework of prolonged masked depressive episodes, 41 observations (6 men, 35 women); 3 — chronic pain as part of hypochondriacal spectrum disorders (limited hypochondria), 15 observations (8 men, 7 women); 4 — chronic pain as part of constitutional anomalies with a tendency to experience pain (pain prone personality), 7 observations (5 men, 2 women). CONCLUSION: A significant association of chronic pain syndromes with stressful events has been established.

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Neurotic depression: approaches to treatment

Cited by 3 publications

References 14 publications

Effect of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly-Pro on the level of pro- and anti-inflammatory cytokines in conditions of stress-induced depression

Effect of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly-Pro on the level of pro- and anti-inflammatory cytokines in conditions of stress-induced depression

Recent approaches to the diagnosis and therapy of monopolar depression

The role of stressful traumatic events, personality traits and psychiatric disorders in the formation of chronic pain syndromes

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