Effect of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly-Pro on the level of pro- and anti-inflammatory cytokines in conditions of stress-induced depression

Abstract

Depression, being a heterogeneous disorder, is one of the most pressing problems in medicine, due to its high prevalence and the development of severe consequences, both medical and social. Currently, there is an urgent need to study the pathophysiological pathways that determine the development of depression in order to identify targets for the development of innovative multi-targeted drugs.Objective: to study the effect of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly-Pro on the level of pro- and anti-inflammatory cytokines in conditions of stress-induced depression.Materials and methods. The experiment was carried out on non-linear male rats 6 months old. age, in the amount of 50 individuals. A depressive-like state was modeled by providing constant sensory contact in rats and daily confrontations for 20 days, forming submissive and aggressive types of behavior.Results. It has been established that His-Phe-Arg-Trp-Pro-Gly-Pro in conditions of stress-induced depression helps restore the cytokine profile, reducing the level of proinflammatory cytokines (IL-1β, IL-6) and increasing the level of anti-inflammatory cytokines (IL-4 , IL-10).Conclusion. The results obtained allow us to consider stress-induced depression as an immune-mediated condition, which determines the need to develop new therapeutic and preventive methods taking into account immunological etiological and pathogenetic mechanisms. Analysis of key cytokines of neuroimmune interactions (IL-1β, IL-4, IL-6, IL-10) in animals exposed to a stress factor that induces the development of depression under the influence of the neuropeptide compound His-Phe-Arg-Trp-Pro-Gly- Pro showed that one of the ways to realize the action of this substance with a neuropeptide structure is to restore cytokine regulation.