Neurotherapeutic applications of nanoparticles in Alzheimer's disease

Sahni, Jasjeet Kaur; Doggui, Sihem; Ali, Javed; Baboota, Sanjula; Dao, Lê H.; Ramassamy, Charles

doi:10.1016/j.jconrel.2010.11.033

Cited by 188 publications

(130 citation statements)

References 330 publications

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“…Some of them have been shown to cross the blood brain barrier (BBB) and have been tested either for diagnosis or treatment of Alzhimer's disease. Finally, the route of nanoparticles administration and the future prospects had also been be discussed [130] .…”

Section: Recent Advances Of Bioenhancersmentioning

confidence: 99%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

386

197

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Section: Recent Advances Of Bioenhancersmentioning

confidence: 99%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

386

197

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“…Neurodegenerative diseases are very commonly encountered with the aging population, in which Alzheimer's disease and Parkinsonism are the most common (Sahni et al, 2011;Gregori et al, 2015). The concept of nose to brain targeting in treatment of neurodegenerative disorders has benefited to a great deal from nanotechnology, provided that these nanocarriers overcome the rapid mucociliary clearance and poor nasal absorption (Sood et al, 2013(Sood et al, , 2014.…”

Section: Introductionmentioning

confidence: 99%

“…The antioxidant activity of the polyphenols curcumin and resveratrol provides the pharmacological basis for their use in many diseases especially neurodegenerative ones (Vanaja et al, 2013). Curcumin was reported to affect the amyloidb pathway by reducing the formation of amyloid-b fibrils and inhibiting its aggregation (Sahni et al, 2011). It also exhibits cytoprotective and anti-inflammatory properties through protection of the cells against amyloid-b-induced toxicity and reduction of the expression of cytokines and chemokines, with improvement in memory and cognitive defects, leading to reversal of neurodegeneration (Agrawal et al, 2010;Sahni et al, 2011;Monroy et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Curcumin was reported to affect the amyloidb pathway by reducing the formation of amyloid-b fibrils and inhibiting its aggregation (Sahni et al, 2011). It also exhibits cytoprotective and anti-inflammatory properties through protection of the cells against amyloid-b-induced toxicity and reduction of the expression of cytokines and chemokines, with improvement in memory and cognitive defects, leading to reversal of neurodegeneration (Agrawal et al, 2010;Sahni et al, 2011;Monroy et al, 2013). Similarly, resveratrol was reported to affect the amyloid-b pathway by reducing the production of amyloid-b peptides and remodeling of the soluble oligomers and fibrils into non-toxic forms of amyloid-b, in addition to its cytoprotective actions and reduction of cognitive defects (Sahni et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

Nasr

2015

Drug Delivery

166

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RESEARCH ARTICLEDevelopment of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery Maha NasrDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt AbstractThe development of mucoadhesive lipidic nanoemulsion based on hyaluronic acid, co-encapsulating two polyphenols (resveratrol and curcumin) for the transnasal treatment of neurodegenerative diseases was attempted in the current manuscript. Nanoemulsions were prepared by the spontaneous emulsification method, and were characterized for their particle size, zeta potential, mucoadhesive strength and morphology. The selected formula was tested for its antioxidant potential, in vitro and ex vivo release of the two polyphenols, safety on nasal mucosa and in vivo quantification of the two drugs in rat brains. Its stability was tested by monitoring the change in particle size, zeta potential, drugs' content and antioxidant potential upon storage for 3 months. The optimized hyaluronic acid based nanoemulsion formula displayed a particle size of 115.2 ± 0.15 and a zeta potential of À23.9 ± 1.7. The formula displayed a spherical morphology and significantly higher mucoadhesive strength compared to its non mucoadhesive counterpart. In addition, the nanoemulsion was able to preserve the antioxidant ability of the two polyphenols and protect them from degradation. Diffusion controlled release of the two drugs was achievable till 6 hours, with an ex vivo flux across sheep nasal mucosa of 2.86 and 2.09 mg/cm 2 hr for resveratrol and curcumin, respectively. Moreover, the mucoadhesive nanoemulsion was safe on nasal mucosa and managed to increase the amounts of the two polypehnols in the brain (about 7 and 9 folds increase in AUC 0-7 h for resveratrol and curcumin, respectively). Hyaluronic acid based lipidic nanoemulsion proved itself as a successful carrier enhancing the solubility, stability and brain targetability of polyphenols.

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“…Recently, many groups are developing new contrast agents to detect amyloid plaques in vivo using ultrasmall superparamagnetic iron oxide nanoparticles, chemically coupled with amyloid-beta (1-42) peptide to detect amyloid deposition (Yang et al, 2011). Further, nanoparticles are currently being used to refine the discovery of biomarkers and molecular diagnostics, which could be applicable to the management of neurodegenerative and neurological diseases (Sahni et al, 2010). Current pharmacotherapies for neurodegenerative diseases that have been successfully encapsulated in nanoparticles are polyphenolic compounds, (EGCG, apolipoprotein E containing curcumin or resveratrol), hormones (estradiol, melatonin, vasoactive intestinal peptide) and amyloid targeted drugs (thioflavin-T and S, coenzyme Q10, amyloid or gold).…”

Section: Nanoparticlesmentioning

confidence: 99%