The Therapeutic Potential of Cell Encapsulation Technology for Drug Delivery in Neurological Disorders

Spuch, Carlos; Navarro, Carmen

doi:10.5772/23222

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…For eg., liposomes especially modified for targeting lymphatics in the subcutaneous mode of administration have been reported. [109] Liposomes have been used in targeted drug delivery in the treatment of breast cancer, [110] for the delivery of antithrombotic/thrombolytic drugs, [111] for overcoming the blood brain barrier (BBB) in the treatment of neurodegenerative diseases, [112] and in numerous other applications. [113]…”

Section: Polymer-conjugated Liposomesmentioning

confidence: 99%

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Chakraborty,

Meher,

Dash

et al. 2023

ChemistrySelect

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The last decade has seen a meteoric rise in studies investigating polymeric aggregates as nanocarriers. When it comes to morphology, size, functionality, and immunostability, polymeric nanocarriers (PNCs) are unparalleled. With characteristics such as large surface area to volume ratio, amphiphilic nano‐environment, non‐toxic components, chemically modifiable composition, external surface alteration potential, uniform particle size, and stimuli‐dependent self‐assembly, PNCs have emerged as strong candidates for therapeutic applications. The article reviews the latest research on different challenges and strategies for targeted drug delivery and shall serve as guide to the researchers in designing site‐specific nanocarriers for application in future. The review systematically discusses the fundamental structural variation of the nanocarriers with emphasis on the influence of chemical alterations and the resulting effects on functionality; addresses the difficulties encountered with modes of administration; target selectivity and stimulus response.

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Section: Polymer-conjugated Liposomesmentioning

confidence: 99%

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Chakraborty,

Meher,

Dash

et al. 2023

ChemistrySelect

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“…This mechanism significantly removes a large portion of nanoparticles from the vascular space, thus limiting their exposure to the cerebrovasculature and resulting in decreased drug concentration in the brain. The problem of rapid uptake of nanoparticles by the reticuloendothelial system was partially solved by coating them with surfactants [39]. Primary surfactants used include polaxamine 908 and polysorbate-80.…”

Section: Nanoparticles Technology As Therapeu-tic Challenges For Neurmentioning

confidence: 99%

Advances in the Treatment of Neurodegenerative Disorders Employing Nanoparticles

Spuch

Ortolano²,

Navarro³

2012

DDF

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Nanoparticles could potentially revolutionise treatment for neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and strokes. Nanotechnologies hold great promise in brain therapy as they protect the therapeutic agent and allow its sustained release; the nanoparticles can be used as gene delivery vehicles. The application of neurotrophic factors is able to modulate neuronal survival and synaptic connectivity and it is a promising therapeutic approach for many neurodegenerative diseases, however, due to limitations posed by the restrictive blood brain barrier (BBB), it is very difficult to ensure long-term administration in the brain. Drug delivery to the brain remains the major challenge for the treatment of all neurodegenerative diseases because of the numerous protective barriers surrounding the central nervous system (CNS). New therapeutics with the capacity to cross the BBB is critically needed for treatment of these diseases. In recent years, nanotechnology had patented new formulations and has evolved as a new treatment for brain diseases, especially for neurodegenerative diseases, where genetically engineered cells can be used to deliver specific growth factors to target cells. Overall, the aim of this review is to summarize the last patents, clinical trials and news related with nanoparticles technology for the treatment of neurodegenerative diseases.

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Regenerative medicine for central nervous system disorders: Role of therapeutic molecules in stem cell therapy

Suárez‐Meade¹,

Carvajal²,

Yasuhara³

et al. 2015

Brain Circ

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The Therapeutic Potential of Cell Encapsulation Technology for Drug Delivery in Neurological Disorders

Cited by 3 publications

References 44 publications

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Advances in the Treatment of Neurodegenerative Disorders Employing Nanoparticles

Regenerative medicine for central nervous system disorders: Role of therapeutic molecules in stem cell therapy

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