Bioavailability enhancers of herbal origin: An overview

Kesarwani, Kritika; Gupta, Rajiv

doi:10.1016/s2221-1691(13)60060-x

Cited by 383 publications

(229 citation statements)

References 98 publications

(84 reference statements)

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“…The oil is commonly obtained by cold pressing the Brazil nut seeds, presenting itself as yellowish and with lightly sweet taste and smell (Kluczkovski et al, 2015). Its composition is mostly unsaturated fatty acids, monounsaturated oleic fatty acid (36.21 to 51%) and oleic fatty acid (34 to 38.28%).…”

Section: * Corresponding Authormentioning

confidence: 99%

“…Its composition is mostly unsaturated fatty acids, monounsaturated oleic fatty acid (36.21 to 51%) and oleic fatty acid (34 to 38.28%). Although oleic fatty acid is the main component of the almond oil, Brazil nut is also a great source of polyunsaturated fatty acids and protein, such as excelsina, selenium and sulfured amino acids forming high bioavailability complexes, and vitamins A, B, C, and E, the last one with antioxidant and immune system activity (Ferreira et al, 2006;Silva et al, 2010;Santos et al, 2011;Kluczkovski et al, 2015).Although several studies have taken place about the properties of this plant and its products, the use of Brazil nut in the pharmaceutical field as an adjuvant has not yet been elucidated.…”

Section: * Corresponding Authormentioning

confidence: 99%

“…For that, immiscible liquids are stabilized by surfactants, reducing their surface tension, emulsifying, dispersing and solubilizing solutes, combining the active ingredient in one of the phases (Acharya and Hartley, 2012;Lawrence and Rees, 2012;Ribeiro et al, 2015). Its benefits include increased API solubility, minimized degradation processes such as thermal and photo degradation, gastric resistance, controlled release of active ingredient, reduction of therapeutic dosage and consequent side effects, improving the adherence to treatment which leads to a significant improvement of a known therapy (Kesarwani and Gupta, 2013). Nanostructures, such as ME, might be able also to increase the absorption of natural ingredients, delivering the active ingredient at the desired site of action in modulated doses (Bonifácio et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Development of Brazil nut oil microemulsion as vehicle for Levamisole

2017

J App Pharm Sci

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Brazil nut (Bertholletia excelsa H. B. K.) is one of the most valuable national Lecythidaceae from Brazil, collaborating with local economy. Besides being rich in nutrients, it has high content of unsaturated fatty acids, proteins and vitamins. On the other hand, levamisole (LMS) is a synthetic imidazothiazole derivative mostly used as agent in anthelmintic treatment; however it is reported to have issues in its oral bioavailability. Microemulsion (ME), immiscible liquids stabilized by surfactants, is a promising bioavailability enhancer nowadays by modifying the release of active ingredient at its site of action, reducing therapeutic dosage with consequent side effects, and increasing absorption of natural ingredients. So, the development of a stable ME containing Brazil nut oil to carry LMS can be a promising pharmaceutical form in this drug therapeutic efficiency behalf. For that, it was developed a stable oil-in-water ME which held pH, conductivity, and refractive index along the study, presenting satisfactory stability under long-term stress conditions. Its particle size is classified as nanostructure (33,35nm), and rheological parameters confirmed a Newtonian behavior, with constant viscosity. The Brazil nut oil ME can be an alternative as adjuvant in pharmaceutical forms and a promising upgrading tool to carry LMS, improving its therapy.

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Section: * Corresponding Authormentioning

confidence: 99%

Section: * Corresponding Authormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Brazil nut oil microemulsion as vehicle for Levamisole

2017

J App Pharm Sci

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“…The benefit of using plant crude extracts is that they contain complex mixtures of compounds which often contribute to the synergistic effect [10]. The stem of the mulberry tree has recently been reported to contain various polyphenolic constituents including flavonoids (morusin), stilbenoids (mulberroside, resveratrol and oxyresveratrol) and coumarins [2].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Stability, Release and in Vitro Digestibility of Mulberry Stem Extract Using Microemulsions

Soonthornsit

Hemstapat

Pitaksutheepong

et al. 2017

Int J Pharm Pharm Sci

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Objective: This study was aimed to develop oral microemulsions and to evaluate their ability to enhance stability, release and intestinal digestion of mulberry stem extract (MSE). Methods:The pseudoternary phase diagrams were constructed using caprylic/capric triglyceride (oil), PEG-8 caprylic/capric glycerides (S), polyglyceryl-3 diisostearate (CoS) and an aqueous phase. The effects of S/CoS (Km) ratio and a cosolvent, i.e. polyethene glycol 400 or propylene glycol (PG), were investigated. The optimized formulations were selected and incorporated with MSE. Then, they were then subjected to stability, release and lipolysis studies. The control solution consisted of 50% PG and 50% water. Results:The formation and characteristics of the microemulsions were influenced by Km and cosolvents. The two optimized formulations (F3 and F4) consisted of 10% oil, 70% S/CoS mixture and 20% aqueous phase were chosen. The Km ratios of F3 and F4 were 4:1 and 3:1. The aqueous phase of F3 and F4 was water and water mixed with PG, respectively. These formulations could improve the stability of MSE better than the control solution. The accumulated release of MSE from F3, F4 and the control solution reached 100% while that of unformulated crude extract reached only 70% after 6 h. The lipolysis study showed that MSE incorporated in both F3 and F4 was digested more than double the percentage compared to that of MSE incorporated in the control solution.Conclusion: MSE was successfully developed in microemulsions. They are shown to be promising vehicles for oral delivery of MSE. Further animal trials are suggested.

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“…So flavonoids result in poor bioavailability, poor permeability, instability and extensive first-pass bioavailability of flavonoids, such as low water solubility, instability to gastric and colonic pH, metabolism by gut microflora, and absorption across the intestinal wall, active efflux mechanism and first pass metabolic effects. Nano carriers could be utilized to enhance bioavailability and bioefficacy of flavonoids because they can increase solubilization potential, alter absorption pathways, and prevent the metabolic degradation within the gastrointestinal tract [1] Catechins, especially those present in green tea, have received considerable attention in recent days due to their favourable biological properties but their therapeutic potential is limited by their low oral bioavailability (<5%) attributed to poor stability and intestinal absorption and a short half-life owing to strong systemic clearance [2]. The present study hypothesized that nano encapsulation of Catechin hydrate (CH) with PLGA will improve the CH stability by protecting capsule from oxidation and improve its aqueous solubility, biological availability, and bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability

Samanta¹,

Bidyut²,

yopadhyay³

et al. 2016

Med chem (Los Angeles)

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Flavonoid is a polyphenolic antioxidant used to treat free radical mediated tissue damage. So flavonoids are the good targets for treatment of many diseases like cancer, toxicity health hazards, neurodegenaration etc. Drug delivery of flavonoid is the novel approach where dosing and drug toxicity can be minimized. Antioxidant Catechin Hydrate (CH) is choosen to make drug delivery vehicle: nanocapsules either alone or in combination with chelator sodium meta borate (SMB) within biodegradable poly-lactide-co-glycolide (PLGA). Sizes of the prepared particles were determined through scanning and atomic force microscopy where less than 50 nm particle sizes were revealed. Bioavailability in serum study determines that shelf life of CH can be increased with nanocapsule delivery compared to free drug. Results demonstrate the efficacy of Nanocapsulated CH to be a potent vehicle for tissue targeting.

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Bioavailability enhancers of herbal origin: An overview

Cited by 383 publications

References 98 publications

Development of Brazil nut oil microemulsion as vehicle for Levamisole

Development of Brazil nut oil microemulsion as vehicle for Levamisole

Enhancement of Stability, Release and in Vitro Digestibility of Mulberry Stem Extract Using Microemulsions

Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability

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