Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability

Samanta, Arpita; Bidyut, B; yopadhyay,; Das, Nirmalendu

doi:10.4172/2161-0444.1000376

Cited by 15 publications

(6 citation statements)

References 18 publications

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“…Earlier reports revealed the nanoscale formulations of catechins can improve stability, gastrointestinal absorption, bioaccumulation, oral bioavailability, and therapeutic efficacy of catechins [150,[281][282][283][284][285]. Catechin-grafted inulin and catechin-grafted chitosan nanoparticles were reported to exhibit improved antidiabetic potential in terms of α-glucosidase and α-amylase inhibitory effects than free catechins and acarbose [286,287].…”

Section: Catechinsmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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Section: Catechinsmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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“…A modified emulsion–diffusion–evaporation method was used to prepare NEQ . Prepared NP and NEQ samples were characterized by using a scanning electron microscope (SEM) and Fourier transform infrared spectroscope (FTIR).…”

Section: Methodsmentioning

confidence: 99%

Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos‐induced hepatic oxidative damage and immunotoxicity in Wistar rats

Suke

Sherekar

Kahale³

et al. 2018

J Biochem & Molecular Tox

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The theme of the present work is to evaluate the protective effect of nanoencapsulated quercetin (NEQ) against chlorpyrifos (CPF)-induced hepatic damage and immune alterations in animals. Nanoparticles (NP) drug encapsulation was prepared. Forty male Wistar rats were divided into eight groups. Two groups served as control and CPF (13.5 mg/kg) treatment for 28 days. Other three groups were free quercetin (QC), NP and NEQ treated with 3 mg/kg respectively for 15 days; whereas remaining three groups received treatment of CPF and QC, NP, NEQ, respectively, for 15 days. The results show that significantly altered oxidative stress in the liver tissue and liver enzyme parameters in blood and immune responses in CPF-treated rats compared to controls. Administration of NEQ attenuated biochemical and immunological parameters. The liver histopathological analysis confirmed pathological improvement. Hence, use of NEQ appeared to be beneficial to a great extent in attenuating and restoring hepatic oxidative damage and immune alteration sustained by pesticide exposure.

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“…Catechins. Catechin nanoscale formulations have previously been shown to increase catechin stability, gastrointestinal absorption, and bioaccumulation [172][173][174][175][176][177]. In terms of α-glucosidase and α-amylase inhibitory activities, catechin-grafted inulin was found to have better antidiabetic potential than free catechins and acarbose [178,179].…”

Section: Luteolinmentioning

confidence: 99%

Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

Islam

Khadija

Islam

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus (DM) is a fatal metabolic disorder, and its prevalence has escalated in recent decades to a greater extent. Since the incidence and severity of the disease are constantly increasing, plenty of therapeutic approaches are being considered as a promising solution. Many dietary polyphenols have been reported to be effective against diabetes along with its accompanying vascular consequences by targeting multiple therapeutic targets. Additionally, the biocompatibility of these polyphenols raises questions about their use as pharmacological mediators. Nevertheless, the pharmacokinetic and biopharmaceutical properties of these polyphenols limit their clinical benefit as therapeutics. Pharmaceutical industries have attempted to improve compliance and therapeutic effects. However, nanotechnological approaches to overcome the pharmacokinetic and biopharmaceutical barriers associated with polyphenols as antidiabetic medications have been shown to be effective to improve clinical compliance and efficacy. Therefore, this review highlighted a comprehensive and up-to-date assessment of polyphenol nanoformulations in the treatment of diabetes and vascular consequences.

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Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability

Cited by 15 publications

References 18 publications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos‐induced hepatic oxidative damage and immunotoxicity in Wistar rats

Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

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