Neuropsychological Functioning in Adolescent Children of Mothers with a History of Bipolar or Major Depressive Disorders

Klimes‐Dougan, Bonnie; Ronsaville, Donna S.; Wiggs, Edythe; Martinez, Pedro E.

doi:10.1016/j.biopsych.2006.03.031

Cited by 137 publications

(135 citation statements)

References 59 publications

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“…In particular, previous studies in BD have consistently shown a robust effect of negative stimuli on cognitive processing Passarotti et al 2011;Pavuluri et al 2012). Although current literature does not view such biases as primary endophenotypic markers of BD, both healthy pediatric BD offspring (Gotlib et al 2005) and adult siblings of BD patients exhibit affective processing biases toward negative stimuli in tasks of impulse control (Clark et al 2005;Klimes-Dougan et al 2006;Maziade et al 2009;Brand et al 2012). Similar to patients with BD, at-risk individuals display deficits in sustained attention and executive functioning (Zalla et al 2004;Frangou et al 2005;Klimes-Dougan et al 2006;Trivedi et al 2008;Kulkarni et al 2010;Diwadkar et al 2011) which suggests that cognitive deficits and affective processing biases could be interrelated, and may constitute markers of vulnerability to BD.…”

Section: Introductionmentioning

confidence: 99%

Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents

Bauer

Frazier

Meyer

et al. 2015

Journal of Child and Adolescent Psychopharmacology

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Background: Bipolar disorder (BD) is characterized by biased processing of emotional information. However, little research in this area has been conducted in youth with BD and at-risk individuals. The goal of this study was to determine whether children with BD displayed comparable or more severe manifestations of this bias relative to offspring of parents with BD. Materials and methods: The sample (n = 57 children and adolescents) included 18 individuals with BD (age: 13.63 -2.99; 8 females), 16 offspring of parents with BD (age: 11.83 -2.96; 9 females) and 23 healthy controls (HC) (age: 12.789 -3.087; 8 females). All participants performed the Affective Go/No-Go (AGN) and the Rapid Visual Processing (RVP) tasks of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Results: Relative to HC, individuals with BD responded faster to correct trials and committed an elevated number of commission errors across all affective conditions of the AGN task. By contrast, BD offspring showed intact performance accuracy but quicker response times than HC. Post-hoc analyses revealed that this behavioral pattern was observed in BD offspring with mental health problems but not in healthy BD offspring. Overall, mean reaction times and total number of errors in the RVP task were comparable across groups. Conclusions: In line with previous findings, subjects with BD encountered difficulties in processing affective information. The tendency toward faster but accurate responses to affective stimuli observed in BD offspring may be a marker of attentional bias toward affective information and constitute a vulnerability marker for mood disorder.

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Section: Introductionmentioning

confidence: 99%

Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents

Bauer

Frazier

Meyer

et al. 2015

Journal of Child and Adolescent Psychopharmacology

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“…While most studies of children at risk for bipolar disorder have focused on clinical description (12), more recent work has also examined potential neurophysiological (13) and neuropsychological (14) deficits. Research should build on this work by assessing the processing of emotional stimuli in first-degree relatives of bipolar patients.…”

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confidence: 99%

Facial Emotion Labeling Deficits in Children and Adolescents at Risk for Bipolar Disorder

Brotman¹,

Guyer²,

Lawson³

et al. 2008

AJP

149

131

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“…Some family relatives of affected patients also carry the endophenotype, although not the disorder phenotype (i.e., affective symptoms) in the case of BD (Adida et al, 2012). In fact, some studies also described attention deficits in unaffected relatives of individuals with mood disorders (Bora, Yucel, & Pantelis, 2009;Brotman, Rooney, Skup, Pine, & Leibenluft, 2009;Grunebaum, Cohler, Kauffman, & Gallant, 1978;Klimes-Dougan, Ronsaville, Wiggs, & Martinez, 2006;Zalla et al, 2004). Gottesman, & Gould (2003) discussed endophenotypes and suggested five criteria that should be characteristic of a trait to qualify it as an endophenotype.…”

Section: Discussionmentioning

confidence: 99%

Attention impairment in bipolar disorder: A systematic review.

Camelo

Velasques

Ribeiro

et al. 2013

Psychology & Neuroscience

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Bipolar disorder (BD) has been associated with marked cognitive impairment, including euthymic periods. Attention is among the most compromised functions in BD. Changes related to learning, memory, and visuospatial abilities can be derived from these attention impairments. The objective of this article is to review the scientific literature on the performance of BD patients in attention tests. A systematic review was performed of controlled studies that assessed attention in patients diagnosed with BD aged between 18 and 65 years. The databases included Medline, LILACS, Cochrane Library, Institute for Scientific Information Web of Knowledge, and Scientific Electronic Library Online (SciELO), and the search encompassed the period from 2008 to 2013. Only studies that had a minimum sample of 10 patients were included. A total of 110 articles fulfilled the inclusion criteria. Compared with healthy control subjects, bipolar patients showed poorer attention performance. Compared with other mental disorders, BD was associated with poorer performance than unipolar depression but better performance than schizophrenia. When bipolar patients in different phases of the disease were compared with one another, the performance of euthymic patients was similar to or better than patients in a depressive state; moreover, manic patients performed worse than depressive patients. Attention is significantly impaired in BD. Attention impairment in BD is milder than in schizophrenia but greater than in unipolar depression. Attention impairment is possibly more severe in manic and depressed episodes than in euthymic periods

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Neuropsychological Functioning in Adolescent Children of Mothers with a History of Bipolar or Major Depressive Disorders

Cited by 137 publications

References 59 publications

Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents

Affective Processing in Pediatric Bipolar Disorder and Offspring of Bipolar Parents

Facial Emotion Labeling Deficits in Children and Adolescents at Risk for Bipolar Disorder

Attention impairment in bipolar disorder: A systematic review.

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