Neuropsychological Correlates of Self-Reported Depression and Self-Reported Cognition Among Patients With Mild Cognitive Impairment

Bruce, Jared M.; Bhalla, Rishi K.; Westervelt, Holly James; Davis, Jennifer; Williams, Vanessa; Tremont, Geoffrey

doi:10.1177/0891988707311032

Cited by 39 publications

(38 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These were assessed using the immediate recall and delayed recall scores from the Hopkins Verbal Learning Test-Revised [27] and the logical memory subtests from the Wechsler Memory Scale -3rd Edition [21] . Consistent with our prior work [28] , we created composite indices for each domain by combining sample-based z-scores that were transformed from the raw test data. For all neuropsychological indices, higher z-scores reflected better performance.…”

Section: Patient Assessmentmentioning

confidence: 99%

Burden among Spousal and Child Caregivers of Patients with Mild Cognitive Impairment

Bruce

McQuiggan

Williams

et al. 2008

Dement Geriatr Cogn Disord

Self Cite

View full text Add to dashboard Cite

Background/Aims: Patients with mild cognitive impairment (MCI) experience cognitive declines and often report significant emotional/behavioral changes. Despite this, few studies have examined the impact of MCI on caregiver burden. The purpose of this study was to confirm the presence of caregiver burden in MCI and examine the relationship between burden and patients’ neuropsychological, behavioral and emotional functioning. Methods: The current study included 51 individuals who had been diagnosed as having MCI using Petersen’s criteria. The patients underwent a thorough neuropsychological evaluation and completed the Beck Depression Inventory and Cognitive Difficulties Scale. The caregivers completed the Zarit Burden Interview and the Revised Memory and Behavior Checklist. Results: More than 30% of the caregivers reported clinically significant burden. Increased caregiver burden was associated with a longer course of cognitive symptoms, patient reports of worse depression and greater cognitive difficulties, and informant reports of patients having more behavior, mood and memory problems. Caregiver burden was not significantly associated with patients’ neuropsychological test performance. Conclusion: The results highlight the importance of addressing patients’ behavioral and emotional difficulties, as well as caregiver burden, as part of the clinical exam in MCI.

show abstract

Section: Patient Assessmentmentioning

confidence: 99%

Burden among Spousal and Child Caregivers of Patients with Mild Cognitive Impairment

Bruce

McQuiggan

Williams

et al. 2008

Dement Geriatr Cogn Disord

Self Cite

View full text Add to dashboard Cite

show abstract

“…For instance, depression, which can be observed in nearly half of individuals with aMCI (Apostolova & Cummings, 2008), has been shown to be associated with the cognitive functioning of these individuals (Dierckx, Engelborghs, De Raedt, De Deyn, & Ponjaert-Kristoffersen, 2007;Bruce et al, 2008;Hudon, Belleville, & Gauthier, 2008). Hudon et al (2008) showed that older adults with aMCI plus depressive symptoms (aMCI-D individuals) were more impaired on tests of executive functions than aMCI individuals with few or no depressive manifestations.…”

Section: Introductionmentioning

confidence: 99%

“…Based on current evidence in the literature (e.g., results from Bruce et al, 2008 revealing that depressive symptoms are associated with better memory performance), our hypotheses are that semantic memory performance will be impaired in both aMCI and aMCI-D participants, but performance will be poorer in the absence of concomitant depressive symptoms. In regards to LLD patients, they will not show a semantic impairment.…”

Section: Introductionmentioning

confidence: 99%

The Relation Between Depressive Symptoms and Semantic Memory in Amnestic Mild Cognitive Impairment and in Late-Life Depression

Brunet

Hudon

Macoir

et al. 2011

J Int Neuropsychol Soc

View full text Add to dashboard Cite

Semantic deficits have been documented in the prodromal phase of Alzheimer's disease, but it is unclear whether these deficits are associated with non-cognitive manifestations. For instance, recent evidence indicates that cognitive deficits in elders with amnestic mild cognitive impairment (aMCI) are modulated by concomitant depressive symptoms. The purposes of this study were to (i) investigate if semantic memory impairment in aMCI is modulated according to the presence (aMCI-D group) or absence (aMCI group) of depressive symptoms, and (ii) compare semantic memory performance of aMCI and aMCI-D groups to that of patients with late-life depression (LLD). Seventeen aMCI, 16 aMCI-D, 15 LLD, and 26 healthy control participants were administered a semantic questionnaire assessing famous person knowledge. Results showed that performance of aMCI-D patients was impaired compared to the control and LLD groups. However, in the aMCI group performance was comparable to that of all other groups. Overall, these findings suggest that semantic deficits in aMCI are somewhat associated with the presence of concomitant depressive symptoms. However, depression alone cannot account solely for the semantic deficits since LLD patients showed no semantic memory impairment in this study. Future studies should aim at clarifying the association between depression and semantic deficits in older adults meeting aMCI criteria. (JINS, 2011, 17, 865-874)

show abstract

“…Emocije i kognicija nisu odvojeni u kompleksnim mentalnim procesima i ponašanju, čak imaju i neke zajedničke neuronske krugove 15,16 . Smatra se da smanjenje memorijskih sposobnosti nije sekudarno kao rezultat emocionalnih disfunkcija, zato što je memorija oštećena i kada nema emocionalnih disfunkcija.…”

Section: Uvodunclassified

Assessment of memory in patients with rheumatoid arthritis

et al. 2011

View full text Add to dashboard Cite

show abstract

Neuropsychological Correlates of Self-Reported Depression and Self-Reported Cognition Among Patients With Mild Cognitive Impairment

Cited by 39 publications

References 27 publications

Burden among Spousal and Child Caregivers of Patients with Mild Cognitive Impairment

Burden among Spousal and Child Caregivers of Patients with Mild Cognitive Impairment

The Relation Between Depressive Symptoms and Semantic Memory in Amnestic Mild Cognitive Impairment and in Late-Life Depression

Assessment of memory in patients with rheumatoid arthritis

Contact Info

Product

Resources

About