The Relation Between Depressive Symptoms and Semantic Memory in Amnestic Mild Cognitive Impairment and in Late-Life Depression

Brunet, Julie; Hudon, Carol; Macoir, Joël; Belleville, Sylvie; Rousseau, François; Bouchard, Rémi W.; Verret, Louis; Chertkow, Howard; Chayer, Céline; Kergoat, Marie‐Jeanne; Joubert, Sven

doi:10.1017/s1355617711000877

Cited by 30 publications

(45 citation statements)

References 39 publications

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“…In patients with dementia, impairments on these tests were found in 49% for the most frequently impaired test (‘Naming of famous faces') and in 38% for the least commonly impaired test (‘Category fluency'). The findings here are supported by previous studies, which show that semantic memory deficits are found in many patients with dementia, and that such deficits may be found in MCI [13,14,16,17]. …”

Section: Discussionsupporting

confidence: 92%

“…Other studies have shown that not only faces but also names for famous buildings are particularly prone to impairment in aMCI [16]. The results demonstrate that deficits on tests relying heavily on semantic memory are found in many patients with dementia, and even that such deficits may also be found in MCI (both in aMCI and non-aMCI) [13,14,16,17]. In patients with dementia, impairments on these tests were found in 49% for the most frequently impaired test (‘Naming of famous faces') and in 38% for the least commonly impaired test (‘Category fluency').…”

Section: Discussionmentioning

confidence: 72%

“…Person knowledge is particularly prone to impairment in aMCI [16]. In aMCI, deficits (on some tests) tapping semantic memory are associated with concomitant depressive symptoms [17]. Patients with (late-life) major depression may have difficulties on some tests that tap semantic memory, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Frequency and Severity of Semantic Deficits in a Consecutive Memory Clinic Cohort

Vogel¹,

Johannsen²,

Stokholm³

et al. 2014

Dement Geriatr Cogn Disord

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Background/Aim: Semantic memory deficits have been shown in dementia and mild cognitive impairment (MCI) by group comparisons. The aim of this study is to investigate the frequency of impairments on tests with semantic content in patients with dementia, MCI (amnestic and non-amnestic) and affective disorders. Methods: A Famous faces test, Boston Naming Test and Category fluency were applied in 114 consecutive memory clinic patients and 95 healthy participants (all participants were 60 years old or older; dementia/MCI patients had Mini-Mental State Examination scores ≥20). Results: Fifty-three patients were classified with dementia, 36 with MCI (14 amnestic, 22 non-amnestic) and 25 with affective disorders. Dementia and MCI patients differed significantly from the control group on all tests. Patients with dementia and MCI had impairments in about 40% of the cases (on the most sensitive tests). However, patients with affective disorders also had mild impairments on tests tapping semantic memory (25% were impaired on the most sensitive tests). Impairments on the Famous faces test were more frequently found in dementia and MCI as compared to patients with affective disorders. Conclusion: Short tests with semantic memory content are sensitive to changes in dementia and MCI, but impairments on such tests may also be found in other diseases, e.g. affective disorders.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 72%

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Frequency and Severity of Semantic Deficits in a Consecutive Memory Clinic Cohort

Vogel¹,

Johannsen²,

Stokholm³

et al. 2014

Dement Geriatr Cogn Disord

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“…Distributional approaches may introduce additional noise into the computation of semantic indices resulting in more variability in measurements and, thus, would need to be further validated. The analysis presented in this manuscript does not take into account depression as a concomitant condition with dementia that may also affect semantic memory and SVF performance (Brunet et al, 2011; Callahan et al, 2015; Klumpp et al, 2010). We plan to investigate effects of depression in future work.…”

Section: Limitationsmentioning

confidence: 99%

Characterizing cognitive performance in a large longitudinal study of aging with computerized semantic indices of verbal fluency

Pakhomov

Eberly²,

Knopman

2016

Neuropsychologia

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A computational approach for estimating several indices of performance on the animal category verbal fluency task was validated, and examined in a large longitudinal study of aging. The performance indices included the traditional verbal fluency score, size of semantic clusters, density of repeated words, as well as measures of semantic and lexical diversity. Change over time in these measures was modeled using mixed effects regression in several groups of participants, including those that remained cognitively normal throughout the study (CN) and those that were diagnosed with mild cognitive impairment (MCI) or Alzheimer’s disease (AD) dementia at some point subsequent to the baseline visit. The results of the study show that, with the exception of mean cluster size, the indices showed significantly greater declines in the MCI and AD dementia groups as compared to CN participants. Examination of associations between the indices and cognitive domains of memory, attention and visuospatial functioning showed that the traditional verbal fluency scores were associated with declines in all three domains, whereas semantic and lexical diversity measures were associated with declines only in the visuospatial domain. Baseline repetition density was associated with declines in memory and visuospatial domains. Examination of lexical and semantic diversity measures in subgroups with high vs. low attention scores (but normal functioning in other domains) showed that the performance of individuals with low attention was influenced more by word frequency rather than strength of semantic relatedness between words. These findings suggest that various automatically semantic indices may be used to examine various aspects of cognitive performance affected by dementia.

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“…Although conventional naming tests provide more information on the maximum naming accuracy rates, our naming test may better reflect the difficulty encountered in naming in real-life situations. It may also compensate for the ceiling effect observed in patients with MCI without comorbid depression [50], while still using the short naming assessment tool that is widely used in current clinical settings. Combining naming tests with evaluation using hallmark neuropsychological deficits may facilitate a more efficient and specific diagnosis of MCI.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Time-Constrained Naming Test in Mild Cognitive Impairment

Hwang

Kim²,

Kim³

et al. 2017

Dement Geriatr Cogn Disord

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Background: Naming difficulties have recently garnered more interest in elderly individuals with mild cognitive impairment (MCI). We anticipate that naming tests with the consideration of response time can provide more informative and distinct neuropsychological profiles of individuals with MCI. Methods: Naming tests were administered to 76 elderly individuals with MCI and 149 healthy elderly (HE). We analyzed the impact of MCI on naming performance and occurrence of “delayed” response. We also validated the predictive power of naming tests with a time-constrained scoring system. Results: MCI participants performed poorer on the noun naming test than HE participants (p = 0.014). MCI was significantly associated with the occurrence of “delayed” response on the noun (odds ratio [OR] = 3.57; 95% confidence interval [CI] = 1.78-7.17) and verb naming tests (OR = 4.66; 95% CI = 2.07-10.46). The time-constrained naming scores were significantly better able to distinguish the MCI from the HE group than the conventional spontaneous naming score on both the noun (p < 0.001) and verb (p = 0.002) naming tests. Conclusions: Our findings broaden the knowledge related to the naming ability in individuals with MCI, with respect to the response time. We also confirmed the validity of the naming tests by applying the “delayed” responses as supplementary assessments in the diagnosis of MCI.

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The Relation Between Depressive Symptoms and Semantic Memory in Amnestic Mild Cognitive Impairment and in Late-Life Depression

Cited by 30 publications

References 39 publications

Frequency and Severity of Semantic Deficits in a Consecutive Memory Clinic Cohort

Frequency and Severity of Semantic Deficits in a Consecutive Memory Clinic Cohort

Characterizing cognitive performance in a large longitudinal study of aging with computerized semantic indices of verbal fluency

Diagnostic Value of Time-Constrained Naming Test in Mild Cognitive Impairment

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