Neuroprotective Effects of Citicoline on Methanol-Intoxicated Retina Model in Rats

Laksmita, Yulinda Arty; Sidik, Machfud; Siregar, Nurjati Chairani; Nusanti, Syntia

doi:10.1089/jop.2021.0018

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…Interestingly, LED photoirradiation (670 nm) could reverse these effects, suggesting an elegant non-invasive possibility of therapy that affects not only the eyes. A decrease in RGC density and thickness alongside increased caspase-3 was also observed in a rat orally administrated methanol-induced toxicity model, an effect reversed by citicoline (1 g/kg/day) [ 155 ]. Very recently, Dorgau and colleagues (2022) aimed to establish a retinal organoid model to study drug toxicity and contribute to the development of treatment strategies [ 86 ].…”

Section: Drugs and Medicinementioning

confidence: 99%

Retinal Toxicity Induced by Chemical Agents

Araújo

Brito

Pereira-Figueiredo

et al. 2022

IJMS

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Vision is an important sense for humans, and visual impairment/blindness has a huge impact in daily life. The retina is a nervous tissue that is essential for visual processing since it possesses light sensors (photoreceptors) and performs a pre-processing of visual information. Thus, retinal cell dysfunction or degeneration affects visual ability and several general aspects of the day-to-day of a person’s lives. The retina has a blood–retinal barrier, which protects the tissue from a wide range of molecules or microorganisms. However, several agents, coming from systemic pathways, reach the retina and influence its function and survival. Pesticides are still used worldwide for agriculture, contaminating food with substances that could reach the retina. Natural products have also been used for therapeutic purposes and are another group of substances that can get to the retina. Finally, a wide number of medicines administered for different diseases can also affect the retina. The present review aimed to gather recent information about the hazard of these products to the retina, which could be used to encourage the search for more healthy, suitable, or less risky agents.

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Section: Drugs and Medicinementioning

confidence: 99%

Retinal Toxicity Induced by Chemical Agents

Araújo

Brito

Pereira-Figueiredo

et al. 2022

IJMS

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“…In an in vitro study, citicoline administration to rat primary retinal cell cultures protected from apoptosis, by means of a reduced frequency of caspases activation and accumulation of apoptosis markers, in the presence of glutamate-induced excitotoxicity and high glucose challenge (Matteucci et al, 2014). In addition, in a recent study on a methanol-intoxicated retina model in rats, it is hypothesized that citicoline is able to minimize the loss of retinal ganglion cells and the disruption of photoreceptors, to suppress ganglion layer edema, to increase the expression of the antiapoptotic BCL-2 protein, and finally to decrease the expression of the proapoptotic caspase-3 protein (Laksmita et al, 2021).…”

Section: Some Additional Notes Involving the Mechanism Of The Describ...mentioning

confidence: 99%

Pharmacological Versus Non-Pharmacological and Ancillary Mechanisms in Eye Drops Used in the Treatment of Glaucoma

Marchesi

Fahmideh²,

Barbieri³

et al. 2022

Front. Drug Saf. Regul.

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Medical Devices Made of Substances (MDMS) are increasingly used in the healthcare system alongside classic medicinal products and constitute an important field of experimentation and innovation in the biomedical field. In fact, these products are rapidly establishing themselves as a valuable therapeutic resource and are available in various forms including, but not limited to, creams, syrups, nasal or oropharyngeal sprays, and eye drops. MDMS are marketed to treat different diseases and the advantages and benefits of the use of these products can be claimed, once proven their clinical activity. What are the differences between medicinal products and MDMS? The substantial difference lies in the mechanism of action: the first case is based on pharmacological, metabolic, and immunological actions while the second one is based on mechanical, or chemical/physical action. Sometimes the boundaries are not well defined and there is a need for a reassessment and a consensus on the underlying concepts and definitions, also in the light of the increasing ability to recognize molecular mechanisms underneath the action of several substances not acting through an easy recognizable unique target (as a receptor, for example). In the present paper, we discuss the role of eye drops as an example of MDMS used in glaucoma, a widely diffused eye disease. The choice is due to the fact that some products used in this field of application and containing similar substances are marketed either as medicinal products or as medical devices or, using other dosage forms, as food supplements. Accordingly, it is important to underscore in the various cases what may be the principal mode of action and the contribution of additional mechanisms as derived, for example, from system pharmacology data. Their analysis may help to exemplify some of the problems around the sometimes fuzzy border between MDMS and medicinal products suggesting the need for new definitions and regulatory decisions about MDMS.

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“…Buelna-Chontal et al [ 424 ] demonstrated that citicoline circumvents mercury-induced mitochondrial damage and renal dysfunction in a model of renal failure in rats. Laksmita et al [ 425 ] demonstrated the potential benefits of citicoline for management of ocular methanol intoxication in an experimental rat model.…”

Section: Pharmacological Actionsmentioning

confidence: 99%

“…Buelna-Chontal et al [ 424 ] demostraron que la citicolina elude el daño mitocondrial inducido por mercurio y la disfunción renal en un modelo de insuficiencia renal en ratas. Laksmita et al [ 425 ] demostraron los beneficios potenciales de la citicolina para el tratamiento de la intoxicación ocular por metanol en un modelo experimental de ratas.…”

Section: Acciones Farmacológicasunclassified

Citicolina: revisión farmacológica y clínica, actualización 2022

Ruiz¹,

Gareri²

2022

RevNeurol

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Resumen Esta revisión se basa en la publicada en 2016 –Secades JJ. Citicolina: revisión farmacológica y clínica, actualización 2016. Rev Neurol 2016; 63 (Supl 3): S1-S73–, e incorpora 176 nuevas referencias aparecidas desde entonces, con toda la información disponible para facilitar el acceso a toda la información en un único documento. La revisión se centra en las principales indicaciones del fármaco, como los accidentes cerebrovasculares agudos y sus secuelas, incluyendo el deterioro cognitivo, y los traumatismos craneoencefálicos y sus secuelas. Se recogen los principales aspectos experimentales y clínicos en estas indicaciones.

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Neuroprotective Effects of Citicoline on Methanol-Intoxicated Retina Model in Rats

Cited by 4 publications

References 13 publications

Retinal Toxicity Induced by Chemical Agents

Retinal Toxicity Induced by Chemical Agents

Pharmacological Versus Non-Pharmacological and Ancillary Mechanisms in Eye Drops Used in the Treatment of Glaucoma

Citicolina: revisión farmacológica y clínica, actualización 2022

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