Retinal Toxicity Induced by Chemical Agents

Araújo, Daniel Souza Monteiro de; Brito, Rafael; Pereira-Figueiredo, Danniel; Santos-Rodrigues, Alexandre dos; Logu, Francesco De; Nassini, Romina; Zin, Andréa; Calaza, Karin da Costa

doi:10.3390/ijms23158182

Cited by 14 publications

(11 citation statements)

References 157 publications

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“…The evidence supports the hypothesis that these compounds ( 3a – l ) slow the development of embryonic zebrafish into juveniles. However, every embryo that survived was later hatched and reached around 100 % of the treated and the negative control, consistent with the present findings [38] . The isolated compound ( 1a ) and the synthesis of benzimidazole derivatives ( 3a – l ) did not significantly alter the morphology of zebrafish embryos, according to the morphological studies of the embryos [39] Figure 5.…”

Section: Resultssupporting

confidence: 88%

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Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish

Vaithiyalingam,

Mohan Kumar,

Kamaraj

et al. 2023

Chemistry & Biodiversity

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Citral (1a), a bioactive component of Cymbopogon citratus (lemongrass) could be isolated and semi‐synthetic analogs synthesized with improved therapeutic properties. Herein we first report describes citral (1a) as a primary material for the synthesis of benzimidazole derivatives between various o‐phenylenediamines (2a–l) in the presence of Diisopropylethylamine (DIPEA) as a commercially available environmentally benign base, ethanol as a green solvent and the yield of all benzimidazole derivatives (3a–l) was between 68–76 %; The semi‐synthetically prepared benzimidazole derivatives (3a–l) were assessed for their anti‐bacterial and anti‐fungal properties. The benzimidazole compounds (3a–b, and 3g–j) exhibit good anti‐microbial activity. In addition, in silico study was carried out to determine the specific binding affinity of the diamine halogen substituted benzimidazole derivatives to the specific target proteins. In silico analysis revealed a high correlation between docking results and experimental results. Finally, benzimidazole demonstrated significant antibacterial and antifungal activity. Zebrafish embryos were subjected to In vivo toxicological test found that all of the benzimidazole compounds (3a–l) were non‐toxic and had low embryotoxicity after 96 h, with an LC50 of 36.425 μg, which could facilitate the design of novel antimicrobial agents using a cost‐effective method.

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Section: Resultssupporting

confidence: 88%

“…However, every embryo that survived was later hatched and reached around 100 % of the treated and the negative control, consistent with the present findings. [38] The isolated compound (1a) and the Figure 3. Survival rates of zebrafish embryos treated with citral (1a) and benzimidazole derivatives (3a-l) at 0-96 hpf.…”

Section: S No Compoundsmentioning

confidence: 99%

Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish

Vaithiyalingam,

Mohan Kumar,

Kamaraj

et al. 2023

Chemistry & Biodiversity

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“…The recent methanol poisoning outbreak during the Covid-19 pandemic was the most signi cant methanol poisoning in Iran and the world. Visual symptoms due to methanol poisoning might appear hours after ingestion, ranging from a progressive decrease in vision to dyschromatopsia, scotoma, and photophobia (15). This study found signi cant changes in inner retinal layers and super cial vasculature.…”

Section: Discussionmentioning

confidence: 51%

Time course study of optical coherence tomography angiography in patients with methanol-induced optic neuropathy

Jafarizadeh

Homaie

Abdollahi

et al. 2023

Preprint

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Introduction: In countries where alcoholic beverages are legally prohibited, methanol toxicity usually occurs due to ingesting homemade alcoholic drinks. The initial ophthalmologic symptoms of methanol toxicity typically appear 6–48 hours after ingestion, and the severity of symptoms varies widely from mild and painless decreased vision to no-light perception vision. Methods This prospective study examines 20 patients with acute methanol poisoning within 10 days of use. Patients underwent ocular examinations, BCVA (Best Corrected Visual Acuity) recording, and OCTA (Optical Coherence Tomography Angiography) of the macula and optic disc. BCVA measurement and imaging were repeated one month and three months after intoxication. Results There was a statistically significant reduction in superficial parafoveal vascular density (P-value = 0.026), inner retinal thickness (P-value = 0.022), RNFL (Retinal Nerve Fiber Layer) thickness (P-value = 0.031), and an increase in cup to disc ratio (P-value < 0.001), and central visual acuity (P-value = 0.002) in this time course. However, there was no statistically significant difference in FAZ (Foveal Avascular Zone) area (P-value = 0.309), FAZ perimeter (P-value = 0.504), FD-300 (Foveal density, vascular density within a 300µm wide region of the FAZ) (P-value = 0.541), superficial vascular density (P-value = 0.187), deep foveal vascular density (P-value = 0.889), deep parafoveal vascular density (P-value = 0.830), choroidal flow area (P-value = 0.464), total retinal thickness (P-value = 0.597), outer retinal thickness (P-value = 0.067), optic disc whole image vascular density (P-value = 0.146), vascular density inside the disc (P-value = 0.864), or peripapillary vascular density (P-value = 0.680) at different times. Conclusion Over time, methanol poisoning can cause changes in retinal layers thickness, vasculature, and optic nerve head. The most important changes include cupping of the optic nerve head, reduction in RNFL thickness, and inner retinal thickness.

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“…The recent methanol poisoning outbreak during the Covid-19 pandemic was the most significant methanol poisoning in Iran and the world. Visual symptoms due to methanol poisoning might appear hours after ingestion, ranging from a progressive decrease in vision to dyschromatopsia, scotoma, and photophobia [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Time course study of optical coherence tomography angiography in patients with methanol induced optic neuropathy

et al. 2023

View full text Add to dashboard Cite

Introduction In countries where alcoholic beverages are legally prohibited, methanol toxicity usually occurs due to ingesting homemade alcoholic drinks. The initial ophthalmologic symptoms of methanol toxicity typically appear 6–48 h after ingestion, and the severity of symptoms varies widely from mild and painless decreased vision to no-light perception vision. Methods This prospective study examines 20 patients with acute methanol poisoning within 10 days of use. Patients underwent ocular examinations, BCVA (Best Corrected Visual Acuity) recording, and OCTA (Optical Coherence Tomography Angiography) of the macula and optic disc. BCVA measurement and imaging were repeated one month and three months after intoxication. Results There was a statistically significant reduction in superficial parafoveal vascular density (P-value = 0.026), inner retinal thickness (P-value = 0.022), RNFL (Retinal Nerve Fiber Layer) thickness (P-value = 0.031), and an increase in cup to disc ratio (P-value < 0.001), and central visual acuity (P-value = 0.002) in this time course. However, there was no statistically significant difference in FAZ (Foveal Avascular Zone) area (P-value = 0.309), FAZ perimeter (P-value = 0.504), FD-300 (Foveal density, vascular density within a 300 μm wide region of the FAZ) (P-value = 0.541), superficial vascular density (P-value = 0.187), deep foveal vascular density (P-value = 0.889), deep parafoveal vascular density (P-value = 0.830), choroidal flow area (P-value = 0.464), total retinal thickness (P-value = 0.597), outer retinal thickness (P-value = 0.067), optic disc whole image vascular density (P-value = 0.146), vascular density inside the disc (P-value = 0.864), or peripapillary vascular density (P-value = 0.680) at different times. Conclusion Over time, methanol poisoning can cause changes in retinal layers thickness, vasculature, and optic nerve head. The most important changes include cupping of the optic nerve head, reduction in RNFL thickness, and inner retinal thickness.

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Retinal Toxicity Induced by Chemical Agents

Cited by 14 publications

References 157 publications

Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish

Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish

Time course study of optical coherence tomography angiography in patients with methanol-induced optic neuropathy

Time course study of optical coherence tomography angiography in patients with methanol induced optic neuropathy

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