Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy

Herrera-Calderon, Oscar; Yuli-Posadas, Ricardo Ángel; Tinco-Jayo, Johnny Aldo; Enciso-Roca, Edwin; Franco-Quino, César; Chumpitaz-Cerrate, Víctor; Figueroa-Salvador, Linder

doi:10.5530/pj.2019.11.243

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…A protective effect against the seizure, which was very similar to diazepam, was demonstrated using SIO administered at 1000mg/kgBW. The researchers inferred that the mechanism of SIO against PTZ-induced seizures involves the protection pathway via the generation of the neurotransmitter GABA and its cumulative antioxidant effects ( Herrera-Calderon et al., 2019 ). The core explanation involves the mechanism by which omega-3 PUFAs extending the refractory period in neurons, thus protect against the seizure episodes.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Sacha Inchi (Plukenetia Volubilis L.): recent insight on phytochemistry, pharmacology, organoleptic, safety and toxicity perspectives

Rodzi

Lee

2022

Heliyon

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Sacha Inchi (Plukenetia Volubilis L.): recent insight on phytochemistry, pharmacology, organoleptic, safety and toxicity perspectives

Rodzi

Lee

2022

Heliyon

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Techniques for extraction, characterization, and application of oil from sacha inchi (Plukenetia volubilis L.) seed: a review

et al. 2022

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An Empirical Analysis of Sacha Inchi (Plantae: Plukenetia volubilis L.) Seed Proteins and Their Applications in the Food and Biopharmaceutical Industries

Rashid,

Yi,

Amin

et al. 2023

Appl Biochem Biotechnol

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Sacha Inchi (Plukenetia volubilis L) is a plant native to the Amazon rainforest in South America known for its edible seeds, which are rich in lipids, proteins, vitamin E, polyphenols, minerals, and amino acids. Rural communities in developing nations have been using this plant for its health bene ts, including as a topical cream for rejuvenating and revitalising skin and as a treatment for muscle pain and rheumatism.Although sacha inchi oil has been applied topically to soften skin, treat skin diseases, and heal wounds, its protein-rich seeds have not yet received proper attention for extensive investigation. Proteins in sacha inchi seeds are generally known to have antioxidant and antifungal activities and are extensively used nowadays in making protein-rich food alternatives worldwide. Notably, large-scale use of seed proteins has begun in nanoparticle and biofusion technologies related to the human health-bene tting sector. To extract and identify their proteins, the current study examined sacha inchi seeds collected from the Malaysian state of Kedah. Our analysis revealed a protein concentration of 73.8 ± 0.002 mg/g of freezedried seed our. Employing liquid chromatography-tandem mass spectrometry (LC-MS/MS) and PEAKS studio analysis, we identi ed 217 proteins in the seed extract, including 152 with known proteins and 65 unknown proteins. This study marks a signi cant step towards comprehensively investigating the protein composition of sacha inchi seeds and elucidating their potential applications in the food and biopharmaceutical sectors. Our discoveries not only enhance our knowledge of Sacha inchi's nutritional characteristics but also pave the way for prospective research and innovative advancements in the realms of functional food and health-related domains.

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Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy

Cited by 3 publications

References 18 publications

Sacha Inchi (Plukenetia Volubilis L.): recent insight on phytochemistry, pharmacology, organoleptic, safety and toxicity perspectives

Sacha Inchi (Plukenetia Volubilis L.): recent insight on phytochemistry, pharmacology, organoleptic, safety and toxicity perspectives

Techniques for extraction, characterization, and application of oil from sacha inchi (Plukenetia volubilis L.) seed: a review

An Empirical Analysis of Sacha Inchi (Plantae: Plukenetia volubilis L.) Seed Proteins and Their Applications in the Food and Biopharmaceutical Industries

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