Neuroprotective Effect of Garcinia Mangostana on Streptozotocin Induced Sporadic Type Alzheimer’s Disease in Mice

Abstract

ABSTRACT:Objectives: The main objective of the study is to determine the neuroprotective potential of ethonolic extract of Garcinia mangostana (EEGM) in mouse against IntracerebroventricularStreptozotocin (ICV -STZ) induced sporadic type Alzheimer"s disease. Methods: Neurotoxicity was induced by ICV injection of STZ (0.5 mg/kg/b.w) as a first dose then the second dose after the 48 hours and the animals were pre-treated with ethanolic extract of Garcinia mangostana for 28 days. To assess the behavioral parameters learning and memory, open field and Y-maze were employed. Acetylcholinesterase, antioxidant enzymes (superoxide dismutase, glutathione peroxidise, reduced glutathione and catalase) were estimated in brain tissue. Results: Pre-treatment with EEGM (200 and 400 mg/kg/b.w) exhibited a dose dependent reduction of AChE levels and increased habituation memory and percentage alteration which are indicative of the enhanced cognitive function. The extract showed significant increase in the antioxidant parameter. Conclusion:The study results suggested that the neuroprotective potentiality of EEGM against ICV STZ induced neurotoxicity. The extract of EEGM proved to have a potential therapeutic action in preventing or decreasing the progression of sporadic Alzheimer"s disease due to aging and oxidative stress.

Memory-Enhancing Effects of Mangosteen Pericarp Water Extract through Antioxidative Neuroprotection and Anti-Apoptotic Action

“…The water-soluble partition of ethanol MPE dramatically diminished AChE activity of SK-N-SH cells [ 60 ]. Moreover, pretreatment with 50% ethanol MPE in streptozotocin-injected male SA mice induced a dose-dependent decrease in AChE activity in the brain [ 61 ]. Additionally, α-mangostin and mangostanol were reported to exhibit selective inhibition of AChE activity assessed by Ellman’s colorimetric method [ 62 ].…”

“…Notably, similar results were previously reported for the water-soluble partition of ethanol extracts, which was also revealed to improve scopolamine-induced memory dysfunction in mice, as assessed via the MWM and passive avoidance tests [ 60 ]. Moreover, pretreatment of streptozotocin-injected mice with 50% ethanol extract increased the habituation memory and cognitive function, as measured by the open field and Y-maze tests [ 61 ]. Furthermore, mangosteen pericarp diet exhibited neuroprotective and antioxidant activities in triple transgenic AD mice.…”

Beneficios de los compuestos bioactivos del mangostán en la enfermedad de Alzheimer: Revisión narrativa

“…Concluyeron que la administración del extracto del pericarpio en la dieta ejerció efectos neuroprotectores, antioxidantes y antiinflamatorios y redujo los niveles de deposición de la placa βA y p-tau en el hipocampo de ratones 3×Tg-AD, lo que podría atenuar aún más el déficit de recuperación de memoria. En otro estudio en el que igualmente emplearon ratones a los que se les indujo la EA, pero antes de ello se les administró un extracto obtenido del pericarpio del mangostán durante 28 días, también observaron una mejora en la función cognitiva, una reducción de la actividad de la AChE y un incremento de las enzimas antioxidantes endógenas (glutatión, catalasa y peroxidasa) [30].…”