Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture

Limpeanchob, Nanteetip; Jaipan, Somkiet; Rattanakaruna, Saisunee; Phrompittayarat, Watoo; Ingkaninan, Kornkanok

doi:10.1016/j.jep.2008.07.039

Cited by 161 publications

(87 citation statements)

References 37 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reported memory enhancing and neuroprotective effects of Bacopa monnieri are consistent with free radical scavenging activities [35][36][37][38].…”

Section: -Iso -Sinaptosomisupporting

confidence: 73%

A Natural Formulation Increases Brain Resistance to Oxidative Stress

Menghini

Ferrante²,

Leporini³

et al. 2014

EJMP

View full text Add to dashboard Cite

Authors' contributions This work was carried out in collaboration between all authors. Authors LM, LB and MV defined experimental protocols and the interpretations of the resultsABSTRACT Aims: Oxidative stress is an imbalance in the pro-oxidant/antioxidant homeostasis, characterized by excess accumulation of reactive oxygen/nitrogen species (ROS/RNS) and free radicals that can be toxic for cells by initiating disruptive peroxidation reactions on cellular substrates such as proteins, lipids, and nucleic acids. Neurons have a high content of unsaturated fatty acids which are easily peroxidable by the elevated levels of ROS and RNS produced by brain oxygen metabolism, yielding isoprostanes among which 8-iso-PGF 2α derived from arachidonic acid represents a stable marker of lipoperoxidation, in vivo. Numerous findings pointed to the protective role of natural products against oxidative stress in the brain. Methodology: In the present work we evaluated the effects of a natural formula containing bacopa extract, vitamin E, astaxanthin and phosphatidylserine on lipoperoxidation in rat brain cortex, both in vivo and in vitro.Results: The results demonstrate that the natural formula could reduce basal and Original Research ArticleEuropean Journal of Medicinal Plants, 4(2): 171-182, 2014 172 hydrogen peroxide-and amyloid β peptide-induced oxidative stress, as evidenced by the reduction of 8-iso-PFG 2α and ROS/RNS production in the rat brain. Conclusion: Results could account for a rational use of herbal products in the treatment of conditions characterized by increased burden of oxidative stress and defective antioxidant mechanisms, such as aging and neurodegenerative disorders.

show abstract

“…The reported memory enhancing and neuroprotective effects of Bacopa monnieri are consistent with free radical scavenging activities [35][36][37][38].…”

Section: -Iso -Sinaptosomisupporting

confidence: 73%

A Natural Formulation Increases Brain Resistance to Oxidative Stress

Menghini

Ferrante²,

Leporini³

et al. 2014

EJMP

View full text Add to dashboard Cite

show abstract

“…Limpeanchob et al [66] demonstrated the neuroprotective effect of EBm in Aβ protein-induced cell death in a primary cortical culture. They found that neurons treated with Aβ protein exhibited high 2-fold rise in acetylcholine esterase (AChE) concentration (which is a component and indicator of neuronal damage), while those treated with Aβ protein and Brahmi had near normal concentration of AChE.…”

Section: Brahmi On β-Amyloidmentioning

confidence: 99%

Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease

Chaudhari

Tiwari

Tiwari³

et al. 2017

Ann Neurosci

119

View full text Add to dashboard Cite

“…As a result, modulation of its toxicity has been identified to be an important therapeutic approach to control the onset of AD (Findeis, 2000;Kawahara and Kuroda, 2000;Ji et al, 2006). In the in vitro model of AD, Aβ has been used to initiate neurotoxicity in various types of cultured cells (Puttfarcken et al, 1996;Boyd-Kimball et al, 2004;Martin et al, 2004;Limpeanchob et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of four medicinal plants on Amyloid-β induced neurotoxicity in SHSY5Y cells

Adewusi

Fouche²,

Steenkamp

2013

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Amyloid-beta peptide (Aβ) is implicated in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder. This study was designed to determine the effect of four medicinal plants used to treat neurodegenerative diseases on Aβ-induced cell death. Cytotoxicity of the ethanol extracts of the plants was determined against SH-SY5Y (human neuroblastoma) cells which were untreated, as well as toxically induced with Aβ, using the MTT and neutral red uptake assays. Cell viability was reduced to 16% when exposed to 20 μM Aβ 25-35 for 72 h. The methanol extract of the roots of Ziziphus mucronata Willd., Lannea schweinfurthii (Engl.) Engl. and Terminalia sericea Burch. ex DC., were the least toxic to the SH-SY5Ycells at the highest concentration tested (100 μg/ml). All four plants tested were observed to reduce the effects of Aβ-induced neuronal cell death, indicating that they may contain compounds which may be relevant in the prevention of AD progression.

show abstract

Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture

Cited by 161 publications

References 37 publications

A Natural Formulation Increases Brain Resistance to Oxidative Stress

A Natural Formulation Increases Brain Resistance to Oxidative Stress

Neurocognitive Effect of Nootropic Drug <b><i>Brahmi</i></b> (<b><i>Bacopa monnieri</i></b>) in Alzheimer's Disease

Effect of four medicinal plants on Amyloid-β induced neurotoxicity in SHSY5Y cells

Contact Info

Product

Resources

About