Neurocognitive Effect of Nootropic Drug &lt;b&gt;&lt;i&gt;Brahmi&lt;/i&gt;&lt;/b&gt; (&lt;b&gt;&lt;i&gt;Bacopa monnieri&lt;/i&gt;&lt;/b&gt;) in Alzheimer's Disease

Chaudhari, Kaustubh S; Tiwari, Nishant; Tiwari, Rakesh R.; Sharma, Rohan

doi:10.1159/000475900

Cited by 133 publications

(57 citation statements)

References 61 publications

(60 reference statements)

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“…Similarly, resveratrol, a naturally occurring phenolic compound widely present in grapes and berries, such as blueberries, mulberries and raspberries, is reported to have protective effects against several neurological complications in cellular and physiological systems, and in clinical trials [136][137][138]. Ginger (Zingiber officinale) and its constituents, 6-gingerol, 6-shogaol, 6-paradol, zingerone, Ginkgo biloba extract, quercetin, berberine, and apigenin are effective for AD in cell cultures and in animal models [139][140][141][142][143][144][145]. Spicatoside A, which is one of the active compounds of Liriope platyphylla, also possess anti-inflammatory and memory repairment in animal models of dementia [146].…”

Section: Plant Extract or Phytochemical For Neurological Complicationsmentioning

confidence: 99%

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

Subedi

Lee

Madiha

et al. 2020

IJMS

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Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible for the modulation of the immune system. TNF-α plays a critical role in almost every type of inflammatory disorder, including central nervous system (CNS) diseases. Although TNF-α is a well-studied component of inflammatory responses, its functioning in diverse cell types is still unclear. TNF-α functions through its two main receptors: tumor necrosis factor receptor 1 and 2 (TNFR1, TNFR2), also known as p55 and p75, respectively. Normally, the functions of soluble TNF-α-induced TNFR1 activation are reported to be pro-inflammatory and apoptotic. While TNF-α mediated TNFR2 activation has a dual role. Several synthetic drugs used as inhibitors of TNF-α for diverse inflammatory diseases possess serious adverse effects, which make patients and researchers turn their focus toward natural medicines, phytochemicals in particular. Phytochemicals targeting TNF-α can significantly improve disease conditions involving TNF-α with fewer side effects. Here, we reviewed known TNF-α inhibitors, as well as lately studied phytochemicals, with a role in inhibiting TNF-α itself, and TNF-α-mediated signaling in inflammatory diseases focusing mainly on CNS disorders.

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Section: Plant Extract or Phytochemical For Neurological Complicationsmentioning

confidence: 99%

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

Subedi

Lee

Madiha

et al. 2020

IJMS

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“…Bacosides also chelate iron and increase glutathione peroxidase. The extracts show neuroprotective effects due to nitric oxide-mediated cerebral vasodilation [28].…”

Section: Bacopa Monniera (Brahmi)mentioning

confidence: 99%

Nature’s Derivative(s) as Alternative Anti-Alzheimer’s Disease Treatments

Sharma

Kumar

2019

ADR

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Alzheimer's disease (AD), the 'Plague of Twenty-First Century,' is a crippling neurodegenerative disease that affects a majority of the older population globally. By 2050, the incidence of AD is expected to rise to 135 million, while no treatment(s) that can reverse or control the progression of AD are currently available. The treatment(s) in use are limited in their ability to manage the symptoms or slow the progression of the disease and can lead to some severe side effects. The overall care is economically burdensome for the affected individuals as well as the caretakers or family members. Thus, there is a pressing need to identify and develop much safer alternative therapies that can better manage AD. This review discusses a multitude of such treatments borrowed from Ayurveda, traditional Chinese practices, meditation, and exercising for AD treatment. These therapies are in practice since ancient times and reported to be beneficial as anti-AD therapies. Ayurvedic drugs like turmeric, Brahmi, Ashwagandha, etc., management of stress by meditation, regular exercising, and acupuncture have been reported to be efficient in their anti-AD usage. Besides, a combination of vitamins and natural dietary intakes is likely to play a significant role in combating AD. We conclude that the use of such alternative strategies will be a stepping-stone in preventing, treating, curing, or managing the disease.

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“…Because of the numerous preclinical and clinical studies on nootropics, several reviews were also conducted to harness the impressive outcomes. The neurocognitive effects of brahmi on cognitive impaired experimental animals was reviewed, the authors opined that brahmi could be a good candidate against AD in human patients 66 . Similarly, the use of galantamie, donepezil, and rivastigmine in mild to moderate AD provide modest cognitive function and behavior as reviewed by Mohammad 67 .…”

Section: Nootropicsmentioning

confidence: 99%

The use of nootropics in Alzheimer’s disease: is there light at the end of the tunnel?

et al. 2019

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Background: The nootropic or simply known as smart drug is a common term given to any compound that is responsible for enhancing mental capability or performance. Alzheimer's disease is characterized clinically by lose of cognitive abilities and pathologically by two hallmark lesions, neurofibrillary tangles and senile plaques. It is unfortunate that AD has no cure yet. In this review attempt has been made to elucidate the general views on AD pathogenic hypotheses and common nootropics being used in AD research. Methods: Articles from credible scientific data bases such as Sciencdirect, Scopus Pubmed, and Google scholar were searched and retrieved using keywords nootropics', Alzheimer's disease', amyloid beta hypotheses', tau hypotheses', cholinergic hypotheses', oxidative stress' and cognitive impairments'. Results: The nootropics act as Ca-channel blockers, AChE inhibitors, glysine antagonists, antioxidants, serotonergic, dopaminergic and glutamic acid receptors antagonists. Conclusion: Based on the available literature searched, there is no doubts the nootropics are attenuating cognitive deficits in both preclinical and clinical studies on AD.

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Neurocognitive Effect of Nootropic Drug <b><i>Brahmi</i></b> (<b><i>Bacopa monnieri</i></b>) in Alzheimer's Disease

Cited by 133 publications

References 61 publications

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

Nature’s Derivative(s) as Alternative Anti-Alzheimer’s Disease Treatments

The use of nootropics in Alzheimer’s disease: is there light at the end of the tunnel?

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