Neuroprotective Effect of an Antioxidant, Lutein, during Retinal Inflammation

Sasaki, Mariko; Ozawa, Yoko; Kurihara, Toshihide; Noda, Kousuke; Imamura, Yutaka; Kobayashi, Saori; Ishida, Susumu

doi:10.1167/iovs.08-2493

Cited by 139 publications

(111 citation statements)

References 42 publications

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“…14,15 In this model, innate immunity causes an impairment in visual function, which can be recorded by electroretinogram (ERG), [15][16][17] and abnormal leukocyte adhesion, which is related to abnormal circulation caused by inflammatory cytokines produced in the retina. 18 The ERG of these mice shows impaired photoreceptor cell function that is associated with the excessive STAT3-dependent degradation of rhodopsin, a visual substance.…”

mentioning

confidence: 99%

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Miyake

Takahashi

Sasaki

et al. 2012

Laboratory Investigation

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Anthocyanin-rich bilberry extract, a plant-derived antioxidant, has been utilized as a popular supplement for ocular health worldwide. However, it is unclear whether this extract has any biological effect on visual function, and the mechanism for such an effect is completely unknown. In this study, we generated a mouse model of endotoxin-induced uveitis (EIU) that shows retinal inflammation, as well as uveitis, by injecting lipopolysaccharide. We pretreated the mice with anthocyanin-rich bilberry extract and analyzed the effect on the retina. Anthocyanin-rich bilberry extract prevented the impairment of photoreceptor cell function, as measured by electroretinogram. At the cellular level, we found that the EIU-associated rhodopsin decreased and the shortening of outer segments in photoreceptor cells were suppressed in the bilberry-extract-treated animals. Moreover, the extract prevented both STAT3 activation, which induces inflammation-related rhodopsin decrease, and the increase in interleukin-6 expression, which activates STAT3. In addition to its anti-inflammatory effect, the anthocyanin-rich bilberry extract ameliorated the intracellular elevation of reactive oxygen species and activated NF-kB, a redox-sensitive transcription factor, in the inflamed retina. Our findings indicate that anthocyanin-rich bilberry extract has a protective effect on visual function during retinal inflammation.

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confidence: 99%

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Miyake

Takahashi

Sasaki

et al. 2012

Laboratory Investigation

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“…The reduction of free radicals and oxidative stress through the administration of lutein (Dilsiz et al, 2006;Li et al, 2009) During the past decade, numerous studies have investigated neuroprotective strategies to reduce / prevent retinal cell death. Recently, intensive efforts have been made to explicate the neuroprotective effects of carotenoids in ocular diseases in vivo (Li et al, 2009;Muriach et al, 2006;Sasaki et al, 2009) and in vitro (Li and Lo, 2010;Nakajima et al, 2009). Various carotenoids are present in human plasma, but only the xanthophylls lutein and zeaxanthin are found in retina in considerable amounts (Junghans et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Dynamic, in vivo, real-time detection of retinal oxidative status in a model of elevated intraocular pressure using a novel, reversibly responsive, profluorescent nitroxide probe

Rayner

Gole

Bottle

et al. 2014

Experimental Eye Research

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“…LPS was injected into the mice intraperitoneally (ip) to induce EUI, then lutein was administered by subcutaneous (sc) injection. It is suggested that lutein was a protective supplement on photoreceptor cells by decreasing production of reactive oxygen species which were causing visual damages, reduced rhodopsin (RHO) levels and induced GFAP expressions [83].…”

Section: Role Of Lutein and Zeaxanthin In Uveitismentioning

confidence: 99%

“…Lutein and zeaxanthin, which are also called macular xanthophylls, show their effects by filtering high energy visible light, mostly with a peak of absorption at 446 nm and ultraviolet radiation lesser, inhibiting lipid peroxidation and reducing reactive species such as singlet oxygen and hydroxyl radical [46][47][48]. These carotenoids have several benefits on human health, including neuroprotective effects [49][50][51], anti-carcinogenic effects [52][53][54][55], anti-diabetic effects [56][57][58], cardioprotective effects [59][60][61], protective effects on skin damages and ocular diseases [62][63][64][65]. Particularly, several studies showed the role of lutein and zeaxanthin in eye diseases.…”

Section: Introductionmentioning

confidence: 99%

An Overview on the Role of Macular Xanthophylls in Ocular Diseases

Sarıaltın¹,

Çoban²

2018

Rec.Nat.Prod.

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Macula lutea, is the center of the retina of the eye, contains high concentrations of lutein and zeaxanthin which can act as a filter against short-wavelength (blue) light. Lutein and zeaxanthin are the only carotenoids detected in human lens which exhibit highly strong free radical scavenging activity. Many epidemiological studies, clinical trials, animal experiments have suggested that lutein and zeaxanthin have antiinflammatory potential with their high antioxidant properties. Several eye diseases including, age-related macular degeneration, uveitis and retinitis pigmentosa are caused by ocular inflammation. Some studies have shown that lutein and zeaxanthin could be protective, curative and preventive against ocular inflammation induced diseases and other ocular disorders such as cataract, glaucoma and choroideremia. The mechanisms responsible for these effects are absorption of near-ultraviolet and blue light, reduction of oxidative stress, inflammation and angiogenesis. Lutein and zeaxanthin can be taken from dietary supplements or a diet high in fruits, vegetables such as kale, spinach and turnip greens. The aim of this review is to evaluate the relationship between the consumption of lutein and zeaxanthin and eye diseases.

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Neuroprotective Effect of an Antioxidant, Lutein, during Retinal Inflammation

Abstract: The present data revealed that the antioxidant lutein was neuroprotective during EIU, suggesting a potential approach for suppressing retinal neural damage during inflammation.

Cited by 139 publications

References 42 publications

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Dynamic, in vivo, real-time detection of retinal oxidative status in a model of elevated intraocular pressure using a novel, reversibly responsive, profluorescent nitroxide probe

An Overview on the Role of Macular Xanthophylls in Ocular Diseases

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