Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti‐Inflammation, and Antiapoptosis

Zheng, Xuan-Qi; Yang, Wenting; Chen, Shuang; Xu, Qingqing; Shan, Chun-Shuo; Zheng, Guo-Qing; Ruan, Jian

doi:10.1155/2017/5058609

Cited by 49 publications

(38 citation statements)

References 32 publications

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“…Brain function and mental performance are affected by psychomotor speed and mental flexibility following damage or injury in the cerebral cortex capillaries; therefore, cigarette smoking can cause some changes in the vascular mechanism for blood flow and some physiological changes in the organs like brain (Mortazavi et al, 2010;Newhouse, Potter, & Singh, 2004). Thus, the smoking mechanism in patients with stroke and dementia has been well-defined through the effect of smoking on the vascular system (Cees De Groot et al, 2000;Raininko & Tilvis, 1993;Rogers, Meyer, Judd, & Mortel, 1985;Terborg, Bramer, Weiller, & Röther, 2002).…”

Section: Discussionmentioning

confidence: 99%

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Alimohammadi

Kanrash

Abolaghasemi

et al. 2019

Basic Clin. Neurosci. J.

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Introduction:Noise is an environmental stressor and can cause or exacerbate mental disorders, and affect the individual performance in certain conditions. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance of the workers in the automotive industry. Methods:This research is a descriptive-analytical study with a cross-sectional design conducted on 300 workers randomly assigned into two groups of noise-exposed and nonexposed. They were examined using computerized tests, including the Tower of London test (TOL), Continuous Performance test (CPT), and Stroop test. The sound pressure levels were measured based on an 8-hour equal-loudness contour in each group according to ISO 9612 standard, using the Testo CEL-815 sound level meter. Results:The study of combined effects of noise and smoking on 12 CPT indicators using the 2-way Analysis of Variance (ANOVA) indicate that noise and smoking factors had a significant impact on the mean number of errors and correct responses in the third 50-stimuli stage, the mean number of errors and correct responses in the second 50-stimuli stage with P<0.001, P<0.001, P=0.012 and P<0.001 for smoking respectively, but only noise affected the other 7 indicators (P<0.001). Conclusion:Smoking and noise have negative impacts on concentration, attention, and cognitive processing speed, which can lead to an individual's mistakes and delayed decision making at the workplace. Highlights• Brain function, cognitive processing speed, and individual performance are significantly lower in smokers compared to non-smokers.• Noise and smoking have significant effects on cognitive performance indicators.• High noise exposure is associated with the risk of an increased number of errors in responding to the test stimuli.• Addiction to cigarettes and other nicotine-containing products harms cognitive performance, including executive functions. Plain Language SummaryExcessive noise in industrial environments can cause hearing impairment, speech problems, sleep disorders, noise annoyance, and decreased efficiency of the workers. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance and psychological flexibility of workers in the automotive industry in Iran. The workers were assessed by proper tools to examine their mental performance and responses to low-or high-frequency noises. We found that long-time exposure to noise significantly affects the individual's performance and psychomotor speed, which resulted in impaired concentration, poor working performance, and increased mistakes at work. This study revealed the relationship between smoking and brain functions in terms of response type and decision-making.

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Section: Discussionmentioning

confidence: 99%

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Alimohammadi

Kanrash

Abolaghasemi

et al. 2019

Basic Clin. Neurosci. J.

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“…It is known to have several remarkable pharmacological effects, such as anti-asthma (Chen et al 2017), anti-diabetic (Bao et al 2016;Zhu et al 2016), hypoglycemic (Li et al 2014), and antitumor (Jin et al 2015;Liu et al 2017b;Wang and Zhan-Sheng 2018) properties. It has also been reported that catalpol acts as a neuroprotective agent for ischemic injury and neurodegenerative diseases (Tian et al 2006;Zhang et al 2007;Zheng et al 2017). In addition, its antioxidant effect can be achieved by blocking ROS production (Jiang et al 2008;Bi et al 2013;Cai et al 2016).…”

Section: Introductionmentioning

confidence: 98%

Catalpol attenuates lipopolysaccharide-induced inflammatory responses in BV2 microglia through inhibiting the TLR4-mediated NF-κB pathway

Choi¹

2019

gpb

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Catalpol, an iridoid glucoside mainly found in the root of Rehmannia glutinosa Libosch, is known to possess various pharmacological effects. Here, we investigated its inhibitory potential against inflammatory responses in lipopolysaccharide (LPS)-stimulated BV2 microglia. Our results showed that catalpol significantly suppressed LPS-induced secretion of pro-inflammatory mediators, including nitric oxide (NO) and prostaglandin E 2. Consistent with these results, catalpol downregulated LPS-stimulated expression of their regulatory enzymes, such as inducible NO synthase and cyclooxygenase-2. Catalpol also inhibited LPS-induced production and expression of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β. Additionally, catalpol suppressed the nuclear factor-kappa B (NF-κB) signaling pathway by disrupting the phosphorylation and degradation of inhibitor of κB-α and blocking the nuclear translocation of NF-κB p65. Moreover, catalpol inhibited LPS-induced expression of toll-like receptor 4 (TLR4) and myeloid differentiation factor 88, which was related to suppression of the binding of LPS with TLR4 on the cell surface. Furthermore, catalpol markedly reduced LPS-induced generation of reactive oxygen species (ROS). Collectively, these results suggest that catalpol can repress LPS-mediated inflammatory action in BV2 microglia through inactivating NF-κB signaling by antagonizing TLR4 and eliminating ROS, indicating that catalpol can have potential benefits by inhibiting the onset and/or treatment of inflammatory diseases.

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“…Catalpol is an iridoid glycoside belonging the iridoid glycoside family and is highly abundant in Rehmannia glutinosa Libosch. Catalpol has been demonstrated to have neuroprotective, anti-apoptotic, anti-inflammatory, and anti-oxidative properties in animal and cell culture studies (Jiang et al 2015;Zheng et al 2017). Hu et al (2016) reported that catalpol inhibited apoptosis in cardiac myocytes via the mitochondrial-dependent caspase pathway.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic efficacy of catalpol against apoptosis in cardiomyocytes derived from human induced pluripotent stem cells

Yang

Feng

et al. 2020

AMB Expr

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Cardiac arrhythmia is an irregular heart rhythm that can lead to serious heart conditions and various organ disorders, and may cause sudden cardiac death. Catalpol belongs to the iridoid glycoside family and is highly abundant in Rehmannia glutinosa Libosch. The study included five groups such as group I (normal control), group II (treatment control), group III (low-dose treatment), group IV (medium-dose treatment) and group V (high-dose treatment). We investigated the therapeutic effects of catalpol on cardiac arrhythmia in human-induced pluripotent stem cells (iPSCs). Cell viability, lactate dehydrogenase (LDH) levels, lipid peroxidation, antioxidant activity, and caspase-3 and caspase-9 activities and protein levels were measured in normal control, treatment control, and treated (1, 10, and 100 µM) iPSC groups. Compared with the treatment control group, catalpol supplementation (1, 10, and 100 µM) increased iPSC cell viability by 7.5, 27.3, and 65.8%, respectively; reduced the LDH levels by 10.4, 31.3, and 75.2%, respectively; and reduced the lipid peroxidation levels by 7.7, 33.0, and 62.6%, respectively. The antioxidant levels were significantly higher in the treatment control group than in the normal control group. Catalpol (100 µM) reduced the caspase-3 and caspase-9 activities by more than 30% and increased expression of the corresponding proteins by more than 50%. These findings suggest that the naturally occurring iridoid glycoside catalpol is effective against aconitine-induced cardiac arrhythmia in iPSCs. Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti‐Inflammation, and Antiapoptosis

Cited by 49 publications

References 32 publications

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Catalpol attenuates lipopolysaccharide-induced inflammatory responses in BV2 microglia through inhibiting the TLR4-mediated NF-κB pathway

Therapeutic efficacy of catalpol against apoptosis in cardiomyocytes derived from human induced pluripotent stem cells

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