Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS study

Han, Yvonne Ming Yee; Chan, Melody M.Y.; Shea, Caroline K S; Lai, Oscar Long-Hin; Krishnamurthy, K.; Cheung, Mei-chun; Chan, Agnes S.

doi:10.1016/j.brs.2022.02.004

Cited by 23 publications

(48 citation statements)

References 69 publications

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“…DLPFC was the most often-targeted region (Fig. 3b,d) and here, anodal tDCS over the left dlPFC (in 7 out of 11 studies) [53][54][55][70][71][72][73] was the most often applied protocol in ASD. In one study 74 , a significant improving effect of bilateral anodal dlPFC tDCS was observed on overall behavioral symptoms.…”

Section: Autism Spectrum Disordermentioning

confidence: 67%

“…Of 11 included studies, only 1 study targeted right TPJ and vmPFC, two key regions in the theory of mind in ASD, and found that anodal vmPFC but not r-TPJ tDCS significantly improved ToM in children with ASD 76 . 9 of 11 studies had repeated protocols in which tDCS was applied on consecutive days for 10, 12, 15, or 20 sessions [52][53][54][55]70,71,[73][74][75] . All of these studies reported significant improvement of their outcome variables (mostly ASD symptoms) and repeated daily sessions…”

Section: Autism Spectrum Disordermentioning

confidence: 99%

“…The stimulation intensity varied from 1 mA (n=9) to 1.5 mA (n=2) and all studies used conventional protocols with electrode sizes of 25 or 35 cm. Only 4 studies applied a double-blind design 54,[72][73][74] and the rest had a single-blind design or not reported the study blinding (Fig 3b) which should be considered with care. See Table 2 for major finings of the studies and Figure 3b for an overview of studies blindness, repetition rate and the target regions.…”

Section: Autism Spectrum Disordermentioning

confidence: 99%

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A systematic review of randomized controlled trials on efficacy and safety of transcranial direct current stimulation in major neurodevelopmental disorders: ADHD, autism, and dyslexia

Salehinejad¹,

Ghanavati²,

Glinski³

et al. 2022

Preprint

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Objective Among the target groups in child and adolescent psychiatry, transcranial direct current stimulation (tDCS) has been more applied in neurodevelopmental disorders specifically, attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and dyslexia. This systematic review aimed to provide the latest update on published randomized-controlled trials applying tDCS in these disorders for evaluating its efficacy and safety.Methods Based on a pre-registered protocol (PROSPERO: CRD42022321430) and using the PRISMA approach, a literature search identified 35 randomized controlled trials investigating the effects of tDCS effects in children and adolescents with ADHD (n=17), ASD (n=11), and dyslexia (n=7). Results In ADHD, prefrontal anodal tDCS is reported more effective compared to stimulation of the right inferior frontal gyrus. Similarly in ASD, prefrontal anodal tDCS was found effective for improving behavioral problems. In dyslexia, stimulating temporoparietal regions was the most common and effective protocol. In ASD and dyslexia, all tDCS studies found an improvement in at least one of the outcome variables while 64.7% of studies (11 of 17) in ADHD found a similar effect. 72% of all tDCS studies with a multi-session design in all three disorders (13 of 18) reported a significant improvement in their outcome variables after the intervention. Randomized, double-blind, controlled trials consisted of around 70.5%, 36.3% and 57.1% of tDCS studies in ADHD, ASD, and dyslexia respectively. tDCS was found safe with no reported serious side effects in 6587 sessions conducted on 745 children and adolescents across 35 studies. Conclusion tDCS was found safe and partially effective. For evaluation of clinical utility, larger randomized controlled trials with a double-blind design and follow-up measurements are required. Titration studies that systematically evaluate different stimulation intensities, duration, and electrode placement is lacking.

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Section: Autism Spectrum Disordermentioning

confidence: 67%

Section: Autism Spectrum Disordermentioning

confidence: 99%

Section: Autism Spectrum Disordermentioning

confidence: 99%

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A systematic review of randomized controlled trials on efficacy and safety of transcranial direct current stimulation in major neurodevelopmental disorders: ADHD, autism, and dyslexia

Salehinejad¹,

Ghanavati²,

Glinski³

et al. 2022

Preprint

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“…Currently, Luckhardt and colleagues [ 37 ] are investigating the effects of repeated multi-channel 2 mA anodal stimulation of the bilateral tempo-parietal junction, combined with computer based cognitive training, in children and adolescents with ASD. Also, in teenagers with autism, it was recently reported that multisession tDCS with left DLPFC cathode placement and right supraorbital region anode placement, paired with concurrent cognitive remediation training, promoted social functioning in individuals with ASD [ 38 ]. In this study, the authors reported that significantly more participants in the active tDCS group experienced short-term itchiness over the stimulation site than participants in the sham tDCS group.…”

Section: Transcranial Direct Current Stimulationmentioning

confidence: 99%

“…In this study, the authors reported that significantly more participants in the active tDCS group experienced short-term itchiness over the stimulation site than participants in the sham tDCS group. However, other side effects were not significantly different between participants in the active and sham groups [ 38 ] Studies are summarized in Table 1 .…”

Section: Transcranial Direct Current Stimulationmentioning

confidence: 99%

Transcranial Direct Current Stimulation as an Approach to Mitigate Neurodevelopmental Disorders Affecting Excitation/Inhibition Balance: Focus on Autism Spectrum Disorder, Schizophrenia, and Attention Deficit/Hyperactivity Disorder

Sousa

Martins

Gonçalves

2022

JCM

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Transcranial direct current stimulation (tDCS) has been proposed as a promising therapy for rehabilitation of neurodevelopmental disorders. In this review, we discuss studies on the impact of tDCS as a therapy for autism, schizophrenia, and attention deficit/hyperactivity disorder, as well as the tDCS’ mechanism of action, and propose future paths of research to optimize tDCS treatment protocols. The mechanism underlying tDCS effects is the modulation of excitatory and/or inhibitory activity, making it a valuable tool for restoring the excitation/inhibition (E/I) balance which is disrupted in many neurodevelopmental disorders. Clinical studies have shown that tDCS therapy is well-tolerated by patients and seems to ameliorate behavior and cognitive functions. Alterations in early development of neuronal circuits lead to disruptions in brain activity in neurodevelopmental disorders. An increasing amount of research into the effects of tDCS on neuronal activity has provided a foundation for its use as a therapy for behavior and cognitive characteristics of neurodevelopmental disorders. Clinical studies show that tDCS appears to ameliorate behavioral and cognitive outcomes of patients with autism, schizophrenia, and attention deficit/hyperactivity disorder. More research is needed to understand the mechanisms of action of tDCS and to optimize treatment protocols.

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High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study

Wang,

Kong

et al. 2023

Autism Research

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The purpose of this study was to determine the effect of the Cz of high‐definition 5‐channel tDCS (HD‐tDCS) on social function in 4–12 years‐old children with autism spectrum disorder (ASD). This study was a randomized, double‐blind, pseudo‐controlled trial in which 45 ASD children were recruited and divided into three groups with sex, age, and rehabilitation treatment as control variables. Each group of 15 children with ASD was randomly administered active HD‐tDCS with the Cz as the central anode, active HD‐tDCS with the left dorsolateral prefrontal cortex (F3) as the central anode, and sham HD‐tDCS with the Cz as the central anode with 14 daily sessions in 3 weeks. The Social Responsiveness Scale Chinese Version (SRS‐Chinese Version) was compared 1 week after stimulation with values recorded 1 week prior to stimulation. At the end of treatment, both the anodal Cz and anodal left DLFPC tDCS decreased the measures of SRS‐Chinese Version. The total score of SRS‐Chinese Version decreased by 13.08%, social cognition decreased by 18.33%, and social communication decreased by 10.79%, which were significantly improved over the Cz central anode active stimulation group, especially in children with young age, and middle and low function. There was no significant change in the total score and subscale score of SRS‐Chinese Version over the Cz central anode sham stimulation group. In the F3 central anode active stimulation group, the total score of SRS‐Chinese Version decreased by 13%, autistic behavior decreased by 19.39%, and social communication decreased by 14.39%, which were all significantly improved. However, there was no significant difference in effect between the Cz and left DLPFC stimulation conditions. HD‐tDCS of the Cz central anode may be an effective treatment for social dysfunction in children with ASD.

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Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS study

Cited by 23 publications

References 69 publications

A systematic review of randomized controlled trials on efficacy and safety of transcranial direct current stimulation in major neurodevelopmental disorders: ADHD, autism, and dyslexia

A systematic review of randomized controlled trials on efficacy and safety of transcranial direct current stimulation in major neurodevelopmental disorders: ADHD, autism, and dyslexia

Transcranial Direct Current Stimulation as an Approach to Mitigate Neurodevelopmental Disorders Affecting Excitation/Inhibition Balance: Focus on Autism Spectrum Disorder, Schizophrenia, and Attention Deficit/Hyperactivity Disorder

High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study

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