High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study

Wang, Yonglu; Wang, Fei; Kong, Yue; Gao, Tianshu; Zhu, Qingyao; Han, Lu; Sun, Bei; Guan, Luyang; Zhang, Ziyi; Qian, Yuxin; Xu, Lingxi; Li, Yun; Fang, Hui; Jiao, Gongkai; Ke, Xiaoyan

doi:10.1002/aur.3018

Cited by 3 publications

(2 citation statements)

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“…One neuromodulation study conducted with participants with social interaction disorders used TENS and reported no adverse events ( Foldes et al, 2021 ). Three studies used tDCS in patients with ASD and reported no adverse events as well as low drop-out rates ( D’Urso et al, 2015 , 2022 ; Wang et al, 2023 ).…”

Section: Resultsmentioning

confidence: 99%

Interpersonal neural synchrony and mental disorders: unlocking potential pathways for clinical interventions

Konrad,

Gerloff,

Kohl

et al. 2024

Front. Neurosci.

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IntroductionInterpersonal synchronization involves the alignment of behavioral, affective, physiological, and brain states during social interactions. It facilitates empathy, emotion regulation, and prosocial commitment. Mental disorders characterized by social interaction dysfunction, such as Autism Spectrum Disorder (ASD), Reactive Attachment Disorder (RAD), and Social Anxiety Disorder (SAD), often exhibit atypical synchronization with others across multiple levels. With the introduction of the “second-person” neuroscience perspective, our understanding of interpersonal neural synchronization (INS) has improved, however, so far, it has hardly impacted the development of novel therapeutic interventions.MethodsTo evaluate the potential of INS-based treatments for mental disorders, we performed two systematic literature searches identifying studies that directly target INS through neurofeedback (12 publications; 9 independent studies) or brain stimulation techniques (7 studies), following PRISMA guidelines. In addition, we narratively review indirect INS manipulations through behavioral, biofeedback, or hormonal interventions. We discuss the potential of such treatments for ASD, RAD, and SAD and using a systematic database search assess the acceptability of neurofeedback (4 studies) and neurostimulation (4 studies) in patients with social dysfunction.ResultsAlthough behavioral approaches, such as engaging in eye contact or cooperative actions, have been shown to be associated with increased INS, little is known about potential long-term consequences of such interventions. Few proof-of-concept studies have utilized brain stimulation techniques, like transcranial direct current stimulation or INS-based neurofeedback, showing feasibility and preliminary evidence that such interventions can boost behavioral synchrony and social connectedness. Yet, optimal brain stimulation protocols and neurofeedback parameters are still undefined. For ASD, RAD, or SAD, so far no randomized controlled trial has proven the efficacy of direct INS-based intervention techniques, although in general brain stimulation and neurofeedback methods seem to be well accepted in these patient groups.DiscussionSignificant work remains to translate INS-based manipulations into effective treatments for social interaction disorders. Future research should focus on mechanistic insights into INS, technological advancements, and rigorous design standards. Furthermore, it will be key to compare interventions directly targeting INS to those targeting other modalities of synchrony as well as to define optimal target dyads and target synchrony states in clinical interventions.

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Section: Resultsmentioning

confidence: 99%

Interpersonal neural synchrony and mental disorders: unlocking potential pathways for clinical interventions

Konrad,

Gerloff,

Kohl

et al. 2024

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…One neuromodulation study conducted with participants with social interaction disorders used TENS and reported no adverse events (Foldes et al, 2021). Three studies used tDCS in patients with ASD and reported no adverse events as well as low drop-out rates (D'Urso et al, 2015(D'Urso et al, , 2022Wang et al, 2023).…”

Section: Feasibility Of Neuroscience-based Intervention Approaches In...mentioning

confidence: 99%

Translational Applications of Neuroimaging

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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A network meta-analysis of non-invasive brain stimulation interventions for autism spectrum disorder: Evidence from randomized controlled trials

Chen,

Lin,

Wang

et al. 2024

Neuroscience & Biobehavioral Reviews

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High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study

Cited by 3 publications

References 77 publications

Interpersonal neural synchrony and mental disorders: unlocking potential pathways for clinical interventions

Interpersonal neural synchrony and mental disorders: unlocking potential pathways for clinical interventions

Translational Applications of Neuroimaging

A network meta-analysis of non-invasive brain stimulation interventions for autism spectrum disorder: Evidence from randomized controlled trials

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