Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: Their visualization and reactions to drug treatment

Costa, M.; Furness, John B.; Cuello, A. Claudio; Verhofstad, A.A.J.; Steinbusch, H W; Elde, R.P.

doi:10.1016/0306-4522(82)90272-x

Cited by 244 publications

(104 citation statements)

References 24 publications

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“…Critically, it has been demonstrated that exogenous 5-HT does not enter noradrenergic or other nonserotonergic axons under the conditions (low 5-HT concentration, desmethylimipramine present) used in the current investigation (Gershon and Sherman, 1982a, b). When endogenous 5-HT is depleted from the myenteric plexus with reserpine, for example, incubation with exogenous 5-HT restores the control pattern of 5HT fibers detected immunocytochemically, indicating that only the fibers that originally contained endogenous 5-HT took up that amine (Costa et al, 1982). Moreover, treatment of mice with the indolic neurotoxin, 5,7-dihydroxytryptam- Vol.…”

Section: Discussionmentioning

confidence: 99%

“…For example, 5-hydroxytryptamine (5HT) is present in enteric neurons (Dreyfus et al, 1977;Costa et al, 1982, Furness andCosta, 1982a), is synthesized from the dietary amino acid, L-tryptophan, by these neurons (Dreyfus et al, 1977;Gershon and Dreyfus, 1980) and is released from them in a Ca*+-dependent manner by electrical stimulation (Jonakait et al, 1979;Gershon and Tamir, 1981). In addition, enteric serotonergic neurons specifically and avidly take up 5-HT, providing an adequate inactivating mechanism for the amine as a transmitter (Gershon and Altman, 1971;Robinson and Gershon, 1971;Gershon et al, 1976;Gershon and Jonakait, 1979).…”

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confidence: 99%

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Morphology and serotonergic innervation of physiologically identified cells of the guinea pig's myenteric plexus

Erde¹,

Sherman²,

Gershon³

1985

J. Neurosci.

116

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Ganglion cells of the myenteric plexus of the guinea pig were physiologically classified as to cell type using intracellular microelectrodes containing horseradish peroxidase (HRP). lnterganglionic fiber tracts were then stimulated in an attempt to elicit slow excitatory postsynaptic potentials (EPSPs) in the impaled cells. The presence or absence of a slow EPSP was noted, following which the cells were injected with HRP through the recording micropipette and finally were incubated with tritiated 5-hydroxytryptamine (r3H]-5-

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Morphology and serotonergic innervation of physiologically identified cells of the guinea pig's myenteric plexus

Erde¹,

Sherman²,

Gershon³

1985

J. Neurosci.

116

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“…Introduction 5-Hydroxytryptamine (5-HT) occurs throughout the gut in enterochromaffin cells (Erspamer, 1954), mast cells (Lewis, 1958) and neurones Costa et al, 1982). Intestinal ion transport can be influenced by exogenously applied 5-HT in a number of species (Donowitz et al, 1980;Hardcastle et al, 1981;Zimmerman & Binder, 1984).…”

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confidence: 99%

Neuronal involvement in type 1 hypersensitivity reactions in gut epithelia

Baird¹,

Cuthbert²

1987

British J Pharmacology

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1 Using a number of 5-hydroxytryptamine (5-HT)-antagonists we have compared their activity against the chloride-secretory response in guinea-pig ileal and colonic epithelia when challenged with 5-HT or antigen. Guinea-pigs sensitized to P-lactoglobulin (PLG) were used throughout; these were obtained by providing animals with cows' milk for drinking. 2 Of methysergide, ketanserin, cyproheptadine and ICS 205-930, only the latter inhibited both the response to 5-HT and to antigen challenge. Methysergide caused a minor, significant effect on 5-HT but not on PLG responses. Ketanserin had no effect on the responses to 5-HT, but both ketanserin and cyproheptadine inhibited the challenge to PLG.3 The data are considered in relation to the current views of receptor subtypes for 5-HT. Some of the reported inhibitors may be non-specific, while we consider there is evidence to support the view that 5-HT3-receptors (neuronal receptors) are involved both in the responses to 5-HT and to antigen challenge. 4 Tetrodotoxin mimicked the effect of ICS 205-930 on both the response to 5-HT and to antigen challenge in sensitized tissues, confirming a neuronal involvement for both types of stimuli.

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“…Os corpos de neurônios serotoninérgicos estão presentes apenas no plexo mioentérico, e possuí traços característicos do tipo Dogiel I, e fibras nervosas serotoninérgicas estão distribuídas em ambos os plexos mioentérico e submucoso (COSTA et al, 1982;LEGAY;SAFFREY;BURNS-TOCK, 1984;NADA;TOYOHARA, 1987;WARDELL;BORNSTEIN;FURNESS, 1994;BARBIERS et al, 1995). As fibras serotoninérgicas estão densamente localizados ao redor de vasos sanguinos na tela submucosa observadas em todos os segmentos do trato gastrointestinal.…”

Section: Inervação Intrínseca Do Sistema Digestório: Sistema Nervoso unclassified

O Eixo Intestino-Cérebro E O Papel Da Serotonina

Vedovato¹,

Trevizan²,

Zucoloto³

et al. 2015

Arq. Ciênc. Saúde Unipar

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VEDOVATO, K.; TREVIZAN, A. R.; ZUCOLOTO, C. N.; BERNARDI, M. D. L.; ZANONI, J. N.; MARTINS, J. V. C. P. O eixo intestinocérebro e o papel da serotonina. Arq. Ciênc. Saúde Unipar, Umuarama, v. 18 n. 1, p. 33-42, jan./abr. 2014 RESUMO: Este trabalho teve por finalidade buscar informações na literatura que descrevam a interação entre o sistema nervoso central (SNC) e sistema nervoso entérico (SNE), e que demonstrem de que forma a serotonina pode atuar no "eixo intestino-cérebro". A serotonina (5-hidroxitriptamina, 5-HT) originalmente descoberta em 1937 por Vittorio Erspamer é uma indolamina, encontrada em células do trato gastrointestinal, plaquetas e no sistema nervoso central de mamíferos, sendo que cerca de 95% da 5-HT corpórea é produzida no intestino. De acordo com a literatura o trato gastrointestinal é inervado por cinco diferentes classes de neurônios: neurônios entéricos, aferentes vagal, aferentes da coluna vertebral, eferentes parassimpáticos e eferentes simpáticos. Os alvos primários da 5-HT que é secretado pelas células enteroendócrinas são as projeções intrínsecas constituída por neurônios aferentes primários da mucosa e plexo mientérico, e projeções extrínsecas, constituída por nervos que transmitem sensações gerais além de náuseas e desconforto para o sistema nervoso central. Após os dados compilados da literatura fica claro que o SNE desempenha papel singular, podendo agir de maneira independente, mas também mantém sinapses com o SNC, por meio do nervo vago. Dessa forma, ambos os sistemas podem influenciar a atividade um do outro mediante o "eixo intestino-cérebro". Adicionalmente a 5-HT apresenta-se como um importante neurotransmissor envolvido na interação entre o SNE o SNC, importante na regulação da sensação de motilidade e secreção intestinal e também atua na ativação e condução da informação ao SNC. PALAVRAS-CHAVE: Sistema nervoso entérico; Sistema nervoso central; Intestino; Serotonina. THE BRAIN-INTESTINE AXIS AND THE ROLE OF SEROTONINABSTRACT: This paper aims to seek literature information describing the interaction between the central and enteric nervous system, and to demonstrate how serotonin may be acting on the "brain-intestine axis." Serotonin, originally discovered in 1937 by Vittorio Erspamer, is an indoleamine found in cells in the gastrointestinal tract, platelets and in the central nervous system of mammals, with approximately 95% of body 5-HT produced in the intestine. According to literature, the gastrointestinal tract is innervated by five different neuron classes: enteric neurons, vagal afferent, spinal afferent, parasympathetic efferent, and sympathetic efferent. The primary targets of serotonin secreted by entero-endocrine cells are the intrinsic projections composed by primary afferent neurons of the mucosa and myenteric plexus, and extrinsic projections, consisting of nerves that send general sensations as well as nausea and general discomfort to the central nervous system. After the data were compiled from the literature, it is clear that the enteric nervous system p...

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Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: Their visualization and reactions to drug treatment

Cited by 244 publications

References 24 publications

Morphology and serotonergic innervation of physiologically identified cells of the guinea pig's myenteric plexus

Morphology and serotonergic innervation of physiologically identified cells of the guinea pig's myenteric plexus

Neuronal involvement in type 1 hypersensitivity reactions in gut epithelia

O Eixo Intestino-Cérebro E O Papel Da Serotonina

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