Neuronal involvement in type 1 hypersensitivity reactions in gut epithelia

Baird, Alan W.; Cuthbert, A. W.

doi:10.1111/j.1476-5381.1987.tb11368.x

Cited by 82 publications

(35 citation statements)

References 31 publications

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“…Also, Hendriks et al (1989) found no effect of cyproheptadine on the response to 5-HT that was resistant to ICS 205-930. Baird & Cuthbert (1987) found a small but non-significant effect of ketanserin on the increase in ISc evoked by 5-HT. The present study suggests that the pharmacology of the electrophysiological effects of 5-HT on secretomotor neurones should be reinvestigated.…”

Section: Discussionmentioning

confidence: 93%

Characterization of 5‐hydroxytryptamine receptors mediating mucosal secretion in guinea‐pig ileum

Johnson

Bornstein

Furness

et al. 1994

British J Pharmacology

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1 The receptor subtypes through which 5-hydroxytryptamine (5-HT) increases electrolyte secretion across the mucosa of guinea-pig ileum were studied. 2 Flat sheep preparations of guinea-pig mucosa plus submucosa were placed in Ussing chambers and the short circuit current (Isc), an index of net electrogenic electrolyte transport across the mucosa, was measured under voltage clamp conditions. 3 Low concentrations of 5-HT (10-300 nM) evoked monophasic increases in ISc which were significantly reduced by hyoscine (100 nM), tetrodotoxin (TTX, 300 nM) and the 5-HT2 receptor antagonist, ketanserin (3-300 nM). 4 Higher concentrations of 5-HT (1-10 ELM) produced biphasic responses which were reduced by hyoscine (100 nM), TTX (300 nM), ketanserin (3-300 nM) and also by the 5-HT3 receptor antagonists, granisetron (1 ptM) and ICS 205-930 (100 nM).5 2-Methyl-5-HT (1-100 M) and a-methyl-5-HT (30nM-30 LM), agonists at 5-HT3 and 5-HT2 receptors respectively, also evoked ISc increases. These responses were reduced by hyoscine (100 nM) and abolished by TTX (300 nM) and the respective receptor antagonists, granisetron (1 ftM) and ketanserin (30 nM). 6 The 5-HT4 receptor antagonist, SDZ205-557 (300 nM) had no effect on the response to 5-HT.7 The TTX-resistant response to 5-HT was not affected by 5-HT2,3 or 4 receptor antagonists.8 These results indicate that 5-HT mediates secretion partly by an action on 5-HT3 receptors located on cholinergic and noncholinergic secretomotor neurones, partly by an action on higher affinity '5-HT2-like' receptors predominantly on noncholinergic neurones, and partly by a direct action on the epithelium.

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Section: Discussionmentioning

confidence: 93%

Characterization of 5‐hydroxytryptamine receptors mediating mucosal secretion in guinea‐pig ileum

Johnson

Bornstein

Furness

et al. 1994

British J Pharmacology

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“…Mast cells (MC) may be one factor influencing the response of visceral afferents to mechanical and chemical stimuli, since MC are found in close proximity to gastrointestinal mucosal sensory nerve fibers containing neuropeptides and a bidirectional pathway among the central nervous system, gut, and MC has been demonstrated (4)(5)(6)(7). The proximity of the MC to the enteric nerves offers an important pathophysiologic role for inducing changes in nerve function and the development of gut hypersensitivity.…”

Section: Introductionmentioning

confidence: 99%

Activated Mast Cells Infiltrate in Close Proximity to Enteric Nerves in Diarrhea-predominant Irritable Bowel Syndrome

et al. 2003

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Mast cells (MC) may be one factor influencing the response of visceral afferent nerves to mechanical and chemical stimuli. The aim of this study was to evaluate the degree of infiltration and activity of colonic MC in irritable bowel syndrome (IBS). Biopsy specimens were obtained from the cecum and rectum of 14 diarrhea predominant IBS and 14 normal controls. Electron microscopy was used to determine the number of intact and degranulated colonic MC and to quantify these separately according to the distance between MC and enteric nerves. An increased number of MC in both cecum and rectum in the IBS group in comparison with the control group was demonstrated (p<0.05). Activated MC in close proximity to enteric nerves were significantly increased in both cecum and rectum of the IBS group compared to control group (p<0.005). In addition, activated MC were significantly increased in close proximity to the nerves compared to those in the remote area in both cecum and rectum of the IBS group (p<0.0001). MC were significantly increased and activated in both cecum and rectum of the IBS group compared to controls. MC may play a role in the gut sensory hypersensitivity of IBS.

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“…That W/W v mice have aberrant secretory responses to ag-induced intestinal anaphylaxis may potentially be explained by the mast celldeficient status of these mice, as abnormalities in fluid secretion in the GI tracts of mast cell-deficient mice have been reported [43]. Mast cell interactions with enteric nerves also appear to be necessary for fluid secretion associated with intestinal anaphylaxis [3,9,43,50]. Further, Sl/Sl d mice appeared to differ from W/W v mice in their intestinal secretory response to CT [32].…”

Section: Discussionmentioning

confidence: 99%