Neuronavigated theta burst stimulation for chronic aphasia: two exploratory case studies

Georgiou, Anastasios M.; Konstantinou, Nikos; Phinikettos, Ioannis; Kambanaros, Maria

doi:10.1080/02699206.2018.1562496

Cited by 18 publications

(16 citation statements)

References 40 publications

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“…Manipulating of synaptic transmission by rTMS is suggested to be based on the long‐term potentiation or depression‐like phenomena of synaptic plasticity. Most prior studies of low‐frequency rTMS (mostly 1 Hz) over right Broca's homologue area in aphasia patients showed benefits in picture naming . To the best of our knowledge, this would be the first case report showing the physiological effect of cTBS over Broca's homologue area on the reorganization of language network in aphasia patient, which was similar to 1 Hz stimulation.…”

Section: Discussionsupporting

confidence: 54%

“…Most prior studies of low-frequency rTMS (mostly 1 Hz) over right Broca's homologue area in aphasia patients showed benefits in picture naming. 1,2,[5][6][7] To the best of our knowledge, this would be the first case report showing the physiological effect of cTBS over Broca's homologue area on the reorganization of language network in aphasia patient, which was similar to 1 Hz stimulation. There was one study that observed cTBS effect on behavioral outcome by measuring the response time of picture naming in normal subjects, which was shorter after cTBS.…”

Section: Discussionmentioning

confidence: 53%

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cTBS effect on language reorganization verified by fMRI and chronometry TMS in an aphasia patient

Ahn

Bashir

Martin

et al. 2019

Neurology & Clinical Neurosc

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The physiologic effect of continuous theta‐burst stimulation (cTBS) in language network has been reported, although it has the clinical benefit of longer‐lasting inhibitory effects with shorter stimulation time. We report 50‐year‐old aphasia patient showed increased activation of the left Broca's area by cTBS for 3 days on contralateral Broca's homologue area (Brodmann area 45) leading to improvements in speech performance. Furthermore, we were able to validate the engaged network and timing in picture naming using chronometry TMS showing significant delay in picture naming only at 200 ms after picture presentation by the left Broca's area (BA 44/45) stimulation. These results may indicate that cTBS over Broca's homologue area (BA 45) led to functional reorganization of language network by shifting it from right to left through interhemispheric interaction.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 53%

cTBS effect on language reorganization verified by fMRI and chronometry TMS in an aphasia patient

Ahn

Bashir

Martin

et al. 2019

Neurology & Clinical Neurosc

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“…Additionally, increases in the left frontotemporoparietal language networks with a significant left hemispheric shift in the left frontal, left temporoparietal, and global language regions were reported at the pre-/post-rTMS fMRI maps of the study [ 96 ]. Further to iTBS investigations, Georgiou et al [ 97 ] recently reported promising findings of neuronavigated continuous theta-burst stimulation (cTBS) over the right pars triangularis (Tr) as a standalone treatment for two individuals with chronic poststroke aphasia in which cTBS was carried over 10 consecutive days for 40 secs per sessions. Their results revealed improvement in language skills in the posttreatment phase, which reverted to baseline scores at follow-up and improvement in the QoL [ 97 ].…”

Section: Discussionmentioning

confidence: 99%

“…Further to iTBS investigations, Georgiou et al [ 97 ] recently reported promising findings of neuronavigated continuous theta-burst stimulation (cTBS) over the right pars triangularis (Tr) as a standalone treatment for two individuals with chronic poststroke aphasia in which cTBS was carried over 10 consecutive days for 40 secs per sessions. Their results revealed improvement in language skills in the posttreatment phase, which reverted to baseline scores at follow-up and improvement in the QoL [ 97 ].…”

Section: Discussionmentioning

confidence: 99%

Transcranial Magnetic Stimulation and Working Memory Training to Address Language Impairments in Aphasia: A Case Study

Kranou-Economidou

Kambanaros

2021

Behavioural Neurology

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Background. Traditionally, people with aphasia (PWA) are treated with impairment-based language therapy to improve receptive and expressive language skills. In addition to language deficits, PWA are often affected by some level of working memory (WM) impairments. Both language and working memory impairments combined have a negative impact on PWA’s quality of life. The aim of this study was to investigate whether the application of intermittent theta-burst stimulation (iTBS) combined with computerized WM training will result in near-ransfer effects (i.e., trained WM) and far-transfer effects (i.e., untrained language tasks) and have a positive effect on the quality of life of PWA. Methods. The participant was a 63-year-old Greek-Cypriot male who presented with mild receptive aphasia and short-term memory difficulties. Treatment was carried out using a multiple baseline (MB) design composed of a pretherapy or baseline testing phase, a therapy phase, and a posttherapy/follow-up phase. The treatment program involved iTBS application to the left dorsolateral prefrontal cortex (DLPFC), an area responsible for WM, for 10 consecutive sessions. The participant received a 3-minute iTBS application followed by 30-minute computer-assisted WM training. Outcome measures included a WM screening test, a standardized aphasia test, a nonverbal intelligence test, story-telling speech samples, a procedural discourse task, and a questionnaire addressing quality of life. These measures were performed three times before the treatment, immediately upon completion of the treatment, and once during follow-up testing at 3 months posttreatment. Results. We found a beneficial effect of iTBS and WM training on naming, reading, WM, reasoning, narrative, communication efficiency, and quality of life (QoL). Implications for Rehabilitation. Noninvasive brain stimulation combined with computerized WM training may be used in aphasia rehabilitation to improve WM and generalize to language improvement.

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“…If one considers a third of all stroke survivors have aphasia, this means, there are roughly 400 new cases of aphasia each year. About 61% continue to experience communication problems 1 year after stroke leading to fewer friendships and smaller social networks [59]. In the exploration of all the above factors influenced by aphasia, the idea of The Aphasia Communication Team -TACT emerged.…”

Section: The Aphasia Communication Team (Tact): a University-affiliated Aphasia Communication Groupmentioning

confidence: 99%

The Importance of Aphasia Communication Groups

Charalambous¹,

Kambanaros²

2022

Aphasia Compendium

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Chronic aphasia is linked to poor functional recovery, depression, and social isolation. In the exploration of the above factors, the role of aphasia communication groups has evolved. Aphasia communication groups for stroke survivors with chronic aphasia and their communication buddies are gaining clinical importance. Communication buddies can be family members, friends, carers, health professionals, and speech and language therapy students who serve as communication facilitators for each group member. Group members share experiences on stroke and aphasia by using technology/tablets and the total communication approach. The benefits or outcomes of group involvement are measured by assessment of functional communication, individual self-ratings of the impact of aphasia on communication, and quality of life after stroke. The use of the communication buddy system, total communication approach, and systematic evaluations enables therapists to measure the effectiveness and efficacy of communication groups in terms of functional communication, social inclusion, and quality of life.

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Neuronavigated theta burst stimulation for chronic aphasia: two exploratory case studies

Cited by 18 publications

References 40 publications

cTBS effect on language reorganization verified by fMRI and chronometry TMS in an aphasia patient

cTBS effect on language reorganization verified by fMRI and chronometry TMS in an aphasia patient

Transcranial Magnetic Stimulation and Working Memory Training to Address Language Impairments in Aphasia: A Case Study

The Importance of Aphasia Communication Groups

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