Neuronal differentiation of chromaffin cells in vitro, induced by extremely low frequency magnetic fields or nerve growth factor: A histological and ultrastructural comparative study

Feria‐Velasco, Alfredo; Castillo‐Medina, Sebastián; Verdugo-Dı́az, Leticia; Castellanos, Emilio; Orozco‐Suárez, Sandra; Sánchez‐Gómez, Concepción; Drucker-Colı́n, René

doi:10.1002/(sici)1097-4547(19980901)53:5<569::aid-jnr7>3.0.co;2-7

Cited by 32 publications

(7 citation statements)

References 19 publications

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“…The daily exposure time was selected on the basis of previous reports demonstrating in vivo neuronal differentiation of chromaffin cells (Drucker‐Colín et al . 1994; Feria‐Velasco et al . 1998).…”

Section: Methodsmentioning

confidence: 99%

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Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3‐nitropropionic model of Huntington's disease

Túnez¹,

Drucker-Colı́n

Jimena

et al. 2006

Journal of Neurochemistry

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An investigation was conducted on the effect of transcranial magnetic field stimulation (TMS) on the free radical production and neuronal cell loss produced by 3-nitropropionic acid in rats. The effects of 3-nitropropionic acid were evaluated by examining the following changes in: the quantity of hydroperoxides and total radical-trapping antioxidant potential (TRAP), lipid peroxidation products, protein carbonyl groups, reduced glutathione (GSH) content, glutathione peroxidase (GSH-Px), catalase and succinate dehydrogenase (SDH) activities; total nitrite and cell death [morphological changes, quantification of neuronal loss and lactate dehydrogenase (LDH) levels]. Our results reveal that 3-nitropropionic acid induces oxidative and nitrosative stress in the striatum, prompts cell loss and also shows that TMS prevents the harmful effects induced by the acid. In conclusion, the results show the ability of TMS to modify neuronal response to 3-nitropropionic acid.

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Section: Methodsmentioning

confidence: 99%

“…1999). In addition, different studies have demonstrated that an extremely low frequency magnetic field (60 Hz, 0.7 mT) induces cell differentiation and increases neurofilaments and neurite growth (Feria‐Velasco et al . 1998; Verdugo‐Díaz et al .…”

mentioning

confidence: 99%

Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3‐nitropropionic model of Huntington's disease

Túnez¹,

Drucker-Colı́n

Jimena

et al. 2006

Journal of Neurochemistry

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“…Similarly, stimulation of cells with MF frequencies apart from the active frequency windows has been shown to act as an inhibitor to prestimulated Ca 2ϩ signaling (87,95). A variety of other MF-induced physiological effects indirectly suggests the involvement of the Ca 2ϩ signal pathway (20,37,55,68,72,76,80,96,98).…”

Section: Physiological Effects Of Mf Exposurementioning

confidence: 98%

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Gartzke

Lange²

2002

American Journal of Physiology-Cell Physiology

102

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Gartzke, Joachim, and Klaus Lange. Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli. Am J Physiol Cell Physiol 283: C1333-C1346, 2002; 10.1152/ajpcell. 00167.2002.-The interaction of weak electromagnetic fields (EMF) with living cells is a most important but still unresolved biophysical problem. For this interaction, thermal and other types of noise appear to cause severe restrictions in the action of weak signals on relevant components of the cell. A recently presented general concept of regulation of ion and substrate pathways through microvilli provides a possible theoretical basis for the comprehension of physiological effects of even extremely low magnetic fields. The actin-based core of microfilaments in microvilli is proposed to represent a cellular interaction site for magnetic fields. Both the central role of F-actin in Ca 2ϩ signaling and its polyelectrolyte nature eliciting specific ion conduction properties render the microvillar actin filament bundle an ideal interaction site for magnetic and electric fields. Ion channels at the tip of microvilli are connected with the cytoplasm by a bundle of microfilaments forming a diffusion barrier system. Because of its polyelectrolyte nature, the microfilament core of microvilli allows Ca 2ϩ entry into the cytoplasm via nonlinear cable-like cation conduction through arrays of condensed ion clouds. The interaction of ion clouds with periodically applied EMFs and field-induced cation pumping through the cascade of potential barriers on the F-actin polyelectrolyte follows well-known physical principles of ion-magnetic field (MF) interaction and signal discrimination as described by the stochastic resonance and Brownian motor hypotheses. The proposed interaction mechanism is in accord with our present knowledge about Ca 2ϩ signaling as the biological main target of MFs and the postulated extreme sensitivity for coherent excitation by very low field energies within specific amplitude and frequency windows. Microvillar F-actin bundles shielded by a lipid membrane appear to function like electronic integration devices for signal-tonoise enhancement; the influence of coherent signals on cation transduction is amplified, whereas that of random noise is reduced. calcium signaling; cell differentiation; Brownian motor hypothesis; cyclotron resonance; hair cell; mechanoelectrical coupling; physiological effects MORE THAN A DECADE OF RESEARCH on field effects in biological systems has yielded rather compelling data for the involvement of the Ca 2ϩ signaling pathway as a primary and main target of magnetic fields (MFs). As first demonstrated by Liburdy and colleagues (52,53) and later on by a number of other authors, the Ca 2ϩ influx pathways of isolated or cultured cells are severely affected by rather low MF energies.The physiological relevance of this finding is high, because Ca 2ϩ represents the most important intracellular signal governing almost all physiological functions in differentiated cells. Most importantly, cytopla...

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“…Auch neuronale Differenzierungsprozesse konnten nachgewiesen werden. Feld-exponierte chromaffine Zellen entwickelten histologische und ultrastrukturelle Merkmale ähnlich denen nach NGF-Behandlung [6]. An Dorsalganglion-Explantaten von Rattenembryonen konnte gezeigt werden, dass pulsierende Magnetfelder das Auswachsen von Neuriten stimulieren [12], jedoch nur in Gegenwart von NGF.…”

Section: Psoriasis Und Camp (Zyklisches Adenosin Monophosphat)unclassified

Behandlung der Schuppenflechte mit Interferenzstrom Elektromagnetische Therapie auf neuen Wegen

Dertinger¹,

Weibezahn²

2002

Akt Dermatol

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EinleitungWeltweite Untersuchungen der letzten Jahre belegen, dass elektromagnetische Felder in wichtige zellbiologische Vorgänge eingreifen können wie Differenzierung, Immunmodulation und andere zentrale Prozesse. Dieser Beitrag will am Beispiel der Behandlung der Schuppenflechte mit Interferenzstrom zunächst aufzeigen, wie sich aus diesen Kenntnissen bereits ein neuer therapeutischer Ansatz ableiten lieû, und am Ende einen Ausblick geben auf weitere viel versprechende elektromagnetische Therapiemöglichkeiten, deren Grundlagen derzeit erarbeitet werden. AbstractWe report on the clinically successful therapy of psoriasis with Interferential Current, a wave form traditionally applied in physiotherapy. The therapeutic strategy focusses on cyclic AMP as target molecule. Based on results with cells exposed in vitro it is shown that the amount of this cellular messenger can be upregulated at specific modulation frequencies of Interferential Current. Interesting perspectives for extending electromagnetic therapy to other diseases emerge from recent publications. We provide a short review of results from investigations in vitro and on animal models which show that, in particular alternating or pulsed magnetic fields, may stimulate processes like angiogenesis, chaperon induction and neuronal differentiation. Originalarbeit 165Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.

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Neuronal differentiation of chromaffin cells in vitro, induced by extremely low frequency magnetic fields or nerve growth factor: A histological and ultrastructural comparative study

Cited by 32 publications

References 19 publications

Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3‐nitropropionic model of Huntington's disease

Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3‐nitropropionic model of Huntington's disease

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Behandlung der Schuppenflechte mit Interferenzstrom Elektromagnetische Therapie auf neuen Wegen

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