Behandlung der Schuppenflechte mit Interferenzstrom Elektromagnetische Therapie auf neuen Wegen

Dertinger, Hermann; Weibezahn, Karl-Friedrich

doi:10.1055/s-2002-33480

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…The observed pain reduction and anti-inflammatory effects of Deep Oscillation ® could be associated with the described distribution of interstitial liquid and enhancement of lymphatic drainage, which might result in a reduction of other potentially noxious substances (traumatic acidosis, prostaglandin etc.). If there are other possibilities, such as direct cell modulating effects by electrical fields, as proven for cell information therapy [12], further investigation is required.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and draining effect of the Deep Oscillation® device tested clinically and on a model of human skin maintained in survival condition

Boisnic¹,

Branchet²

2013

European Journal of Dermatology

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59To cite this article: Boisnic S, Branchet MC. Anti-inflammatory and draining effect of the Deep Oscillation ® device tested clinically and on a model of human skin maintained in survival condition.The objective of this study was to evaluate the anti-inflammatory, toning and draining effect of the Deep Oscillation ® device. The Deep Oscillation ® device uses the forces of pulsed electrostatic attraction and friction to provoke oscillations that act on the epidermis, dermis, and subcutaneous layers of tissue. An ex-vivo study was first completed by using a model of skin maintained in survival condition. The draining and antiinflammatory effects of the device were determined by pro-inflammatory cytokine assay and by histological analysis of capillary dilation. The analgesic effectiveness of the Deep Oscillation ® was then evaluated by immunohistochemical analysis of TRPV1. To corroborate this data, a clinical study was conducted by selecting 20 subjects with periorbital bags or dark circles to undergo treatment with the device. Evaluations included photography, dermatological scores as well as ultrasound analyses. Using an ex-vivo model of human skin maintained in survival condition, the Deep Oscillation ® device was effective in reducing inflammation with a significant reduction of dilated capillaries and IL8, while lowering sensory receptor levels. Clinically, the device was successful in reducing both dark circles and bags by an average of 40%.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and draining effect of the Deep Oscillation® device tested clinically and on a model of human skin maintained in survival condition

Boisnic¹,

Branchet²

2013

European Journal of Dermatology

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Response of cyclic AMP by DMSO differentiated HL‐60 cells exposed to electric interferential current after prestimulation

Sontag¹

2004

Bioelectromagnetics

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The action of interferential current (IFC) upon intracellular content of cyclic adenosine monophosphate (cAMP) after prestimulation with the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) has been investigated. Human promyelocytes (HL-60) differentiated to granulocytes by dimethylsulphoxide (DMSO) have been treated with different concentrations of fMLP. This enhances their cAMP content. The half maximal effective concentration (EC50) was about 4 nM. Exposure to IFC with modulation frequencies of 35 and 125 Hz (5 min, 250 microA/cm2) after prestimulation with various concentrations of fMLP had no enhancing effect at low or high concentrations of fMLP. In contrast, at medium concentrations in the range of about 100 pM fMLP, a significant enhancement of cAMP could be observed. This synergistic effect of fMLP and IFC has been examined in detail by varying the modulation frequency, current density, and exposure time. Enhancement of cAMP content could be observed at certain modulation frequencies and exposure times suggesting a window effect, whereas for the current density in the range measured (8.5 microA/cm2-2.5 mA/cm2) a constant enhancement could be observed. The synergistic effect of fMLP and IFC could only be observed in the treatment sequence of fMLP followed by IFC; an inverse sequence had no effect on the cAMP content. .

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IL-8 Release of HL-60 Cells Treated with Electric Currents of Different Wave Forms

Sontag

Weibezahn

2007

Electromagnetic Biology and Medicine

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Human promyelocytic leukaemia HL-60 cells which have been differentiated by DMSO to granulocytes were used to investigate the effect of different waveforms on the release of interleukine-8 (IL-8). The cells were prestimulated with 100 pM fMLP and subsequently treated for 15 min with different electrical fields and currents. Three hours later the release of IL-8 into the medium was determined by ELISA. Varying the frequency of the sinusoidal electrical current between 0 and 20 Hz resulted in 2 maxima of IL-8 release at 5 and 13 Hz. Prestimulated cells were treated with sine-, triangular-, and rectangular-waveforms at 5 Hz in the current intensity range of 0-3 mA/cm(2). For the three waveforms tested, the IL-8 release was enhanced 1.5 fold. Treatment of the cells with capacitively coupled electric fields of 5 Hz using field strengths between 0 and 10 V(eff)/cm had no effect on the release of IL-8. In comparison to the positive results after sine wave exposure alone, an exposure with sine wave current to which noise had been superimposed had no effect on the HL-60 cells. From these investigations it can be concluded that for electrical current treatment of prestimulated HL-60 cells the release of IL-8 does not depend on the waveform if the waveform information is not destroyed by superimposed noise.

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Behandlung der Schuppenflechte mit Interferenzstrom Elektromagnetische Therapie auf neuen Wegen

Cited by 3 publications

References 15 publications

Anti-inflammatory and draining effect of the Deep Oscillation® device tested clinically and on a model of human skin maintained in survival condition

Anti-inflammatory and draining effect of the Deep Oscillation® device tested clinically and on a model of human skin maintained in survival condition

Response of cyclic AMP by DMSO differentiated HL‐60 cells exposed to electric interferential current after prestimulation

IL-8 Release of HL-60 Cells Treated with Electric Currents of Different Wave Forms

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