Neuron-autonomous transcriptome changes upon ischemia/reperfusion injury

Shi, Jinlong; Xia, Chen; Li, Haiying; Wu, Youjia; Wang, Shouyan; Shi, Wei; Chen, Jian; Ni, Yaohui

doi:10.1038/s41598-017-05342-9

Cited by 21 publications

(18 citation statements)

References 40 publications

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“…These reports indicate the influence of exposure to chronic noise on the mental and psychological conditions, including performance and processing speed. Several studies that have examined the relationship of human cognitive performance with other physical factors have also reported similar results (Haines et al, 1998;Losier, McGrath, & Klein, 1996;Sanz et al, 1993). Sound pressure levels above 65 dB can potentially affect the cognitive performance and other nonauditory functions, increase the risk of different human errors at work where people long exposed to loud noises, and cause cognitive impairment (delayed reaction time, poor attention, etc.…”

Section: Discussionmentioning

confidence: 80%

“…Research evidence suggests that long-term exposure to noise can affect cognitive performance in central processing and language comprehension (Alimohammadi, Nassiri, Azkhosh, & Hoseini, 2010). Besides, it can harm continuous and visual attention (Haines, Stansfeld, Job, & Berglund, 1998;Sanz, García, & García, 1993). Workers exposed to long-time environmental noises have the lower hearing ability, speech ability, and memory (Hygge, Evans, & Bullinger, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Alimohammadi

Kanrash

Abolaghasemi

et al. 2019

Basic Clin. Neurosci. J.

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Introduction:Noise is an environmental stressor and can cause or exacerbate mental disorders, and affect the individual performance in certain conditions. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance of the workers in the automotive industry. Methods:This research is a descriptive-analytical study with a cross-sectional design conducted on 300 workers randomly assigned into two groups of noise-exposed and nonexposed. They were examined using computerized tests, including the Tower of London test (TOL), Continuous Performance test (CPT), and Stroop test. The sound pressure levels were measured based on an 8-hour equal-loudness contour in each group according to ISO 9612 standard, using the Testo CEL-815 sound level meter. Results:The study of combined effects of noise and smoking on 12 CPT indicators using the 2-way Analysis of Variance (ANOVA) indicate that noise and smoking factors had a significant impact on the mean number of errors and correct responses in the third 50-stimuli stage, the mean number of errors and correct responses in the second 50-stimuli stage with P<0.001, P<0.001, P=0.012 and P<0.001 for smoking respectively, but only noise affected the other 7 indicators (P<0.001). Conclusion:Smoking and noise have negative impacts on concentration, attention, and cognitive processing speed, which can lead to an individual's mistakes and delayed decision making at the workplace. Highlights• Brain function, cognitive processing speed, and individual performance are significantly lower in smokers compared to non-smokers.• Noise and smoking have significant effects on cognitive performance indicators.• High noise exposure is associated with the risk of an increased number of errors in responding to the test stimuli.• Addiction to cigarettes and other nicotine-containing products harms cognitive performance, including executive functions. Plain Language SummaryExcessive noise in industrial environments can cause hearing impairment, speech problems, sleep disorders, noise annoyance, and decreased efficiency of the workers. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance and psychological flexibility of workers in the automotive industry in Iran. The workers were assessed by proper tools to examine their mental performance and responses to low-or high-frequency noises. We found that long-time exposure to noise significantly affects the individual's performance and psychomotor speed, which resulted in impaired concentration, poor working performance, and increased mistakes at work. This study revealed the relationship between smoking and brain functions in terms of response type and decision-making.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Alimohammadi

Kanrash

Abolaghasemi

et al. 2019

Basic Clin. Neurosci. J.

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“…The lncRNA expression pattern clustering was based on a previously published algorithm (18). To perform the coding non-coding co-expression network analysis, Pearson's correlation was calculated and the significant correlation pairs (>0.999) were selected, which were used to construct the network (19).…”

Section: Methodsmentioning

confidence: 99%

Profiling lncRNA alterations during TNF‑α induced osteogenic differentiation of dental pulp stem cells

Tao

Liu

et al. 2019

Mol Med Report

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The multipotent and easily accessible characteristics of dental pulp stem cells (DPSCs) make them a promising target for bone tissue engineering. Long non-coding RNAs (lncRNAs) have an important role in the osteogenic differentiation of mesenchymal stem cells. Nevertheless, whether lncRNAs are involved in the osteogenic differentiation of DPSCs remains unclear. The present study examined the expression alterations of lncRNAs in tumor necrosis factor-α induced osteogenic differentiation of DPSCs. Following identification of differentially expressed lncRNAs at different time points by reverse transcription-quantitative polymerase chain reaction, profiling analysis was performed and a profile was further validated, in which lncRNA expression levels demonstrated significant upregulation. The next generation sequencing analysis identified 77 (58 upregulated and 19 downregulated) and 133 differentially expressed lncRNAs (73 upregulated and 60 downregulated) at 7 and 14 days post-treatment, respectively. In addition, 34 lncRNAs were predicted to be strongly associated with 336 mRNA transcripts that underwent significant alterations during osteogenic differentiation. The present data demonstrated that one lncRNA, X inactive specific transcript, is essential for efficient osteogenic differentiation of DPSCs by alkaline phosphatase staining. In summary, the present findings provide insight for the understanding of how non-coding RNAs are involved in regulating the osteogenic differentiation of DPSCs, which may further advance the translational studies of bone tissue engineering.

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“…Polymorphisms in GABRA4 are also associated with autism (Collins et al, 2006;Ma et al, 2005). Likewise, other genes that are important in the differentiation and migration of GABAergic interneurons and regulate the development of GABAergic neurons such as ARX are related to ASD.…”

Section: Gama-aminobutyric Acid and Autism Spectrum Disordermentioning

confidence: 99%

Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study

Mollajani

Joghataei

Tehrani‐Doost

2019

Basic Clin. Neurosci. J.

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Introduction: Autism Spectrum Disorder (ASD) is characterized by several impairments in communications and social interactions, as well as restricted interests or stereotyped behaviors. Interventions applied for this disorder are based on multi-modal approaches, including pharmacotherapy. No definitive cure or medication has been introduced so far; therefore, researchers still investigate potential drugs for treating ASD. One of the new medications introduced for this purpose is bumetanide. The present article aimed to review the efficacy of this drug on the core symptoms of ASD and its potential side effects. Methods:We searched all papers reported on pharmacokinetics, pharmacodynamics, efficacy, and adverse effects of bumetanide on animal models and humans with ASD. The papers were extracted from the main databases of PubMed, Web of Science, and Scopus. Results:The findings revealed that cortical neurons have high Chloride ion (Cl−)i and excitatory actions of gamma-aminobutyric acid in the valproic acid animal model with ASD and mice with fragile X syndrome. Bumetanide, which has been introduced as a diuretic, is also a high-affinity-specific Na+-K+-Cl− cotransporter (NKCC1) antagonist that can reduce Cl− level. The results also indicate that bumetanide can attenuate behavioral features of autism in both animal and human models. Moreover, the studies showed that such medication could activate fusiform face area in individuals with ASD while viewing emotional faces. Also, recent findings suggest that a dose of 1 mg/d of this drug, taken twice daily, might be the best compromise between safety and efficacy. Conclusion:Recent studies provided some evidence that bumetanide can be a novel pharmacological agent in treating core symptoms of ASD. Future studies are required to confirm the efficacy of this medication in individuals with ASD. Citation: Mollajani, R., Taghi Joghataei, M., & Tehrani-Doost, M. (2019). Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study. Basic and Clinical Neuroscience, 10(5), 433-442. http://dx.doi.

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Neuron-autonomous transcriptome changes upon ischemia/reperfusion injury

Cited by 21 publications

References 40 publications

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Profiling lncRNA alterations during TNF‑α induced osteogenic differentiation of dental pulp stem cells

Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study

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