Neurologic Outcomes at School Age in Very Preterm Infants Born With Severe or Mild Growth Restriction

Abstract

In preterm children, growth restriction was associated with mortality, cognitive and behavioral outcomes, as well as school difficulties.

Functional outcome of very preterm–born and small-for-gestational-age children at school age

“…This is more so in verbal IQ than in performance IQ (10). A large population based cohort study reported follow up data of the EPIPAGE cohort at 5 y of age (6). Their inclusion rate for the cognitive tests was only Articles Tanis et al 65%.…”

“…Studies on very preterm SGA children are scarce, and the findings are contradictory. Some stud ies report lower IQ scores (6,9,10) and more behavioral problems or attention deficits in these children (9) as compared with con trols (6), whereas others have found no differences as regards behavioral problems and attention deficits (6,10). Cognitive impairment was restricted to verbal IQ only (10).…”

“…In addition, it has been shown that children born small for gestational age (SGA) are also at risk for poor neurodevelopmental outcome (5,6). This holds good for SGA children born at term and also for those born preterm (<37 wk) (5).…”

“…We expect that their func tional outcomes would be poorer than those of very preterm but appropriate for gestational age (AGA) children (6,9,10). The question is whether this poor functional outcome at school age can be attributed to preterm birth alone, or whether being born SGA poses additional risks.…”

DOHaD : conséquences à long terme de la pathologie périnatale

“…Des altérations structurelles et fonctionnelles de noyaux hypothalamiques sont à l'origine de troubles de la régulation de la prise alimentaire (quantitative et qualitative) et sont impliquées dans l'émer-gence des pathologies métaboliques [8]. Le retard de croissance intra-utérin est associé à de moindres performances scolaires et à plus de troubles du comportement, de l'attention et des fonctions exécutives [9]. Les complications respiratoires associées au retard de croissance intra-utérin illustrent bien le concept de plasticité adaptative.…”