Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness

Checkley, Stuart

doi:10.1017/s0033291700039593

Cited by 235 publications

(87 citation statements)

References 163 publications

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“…This indicates that depression might increase the risk of morbidity among evening types. Noradrenergic transmission has been implicated as dysfunctional in depressed individuals (Checkley, 1980;Stone et al, 2011) and may underlie some of the associations we found herein such as a faster resting heart rate. However, because we did not assess any direct indicators of this transmission pathway, it remains speculative.…”

Section: Discussionmentioning

confidence: 59%

Evening types are prone to depression

Merikanto

Lahti

Kronholm

et al. 2013

Chronobiology International

207

114

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Certain preferences for the timing of daily activities (chronotype) may predispose an individual to sleep problems and mood disorders. In this study, we have examined the link between chronotypes and depression. Participants (N ¼ 6071) were recruited from a random sample of the general population aged 25 to 74 yrs living in defined geographical areas, as part of the National FINRISK Study in 2007 in Finland. Chronotype assessment was based on six items from the original Horne-Ö stberg Morningness-Eveningness Questionnaire. Depression was assessed with four self-reported items, including two probes for a diagnosis of a major depressive episode, diagnosed or treated depression, and use of antidepressants. We also analyzed correlations between chronotype and several health indicators, such as systolic and diastolic blood pressures, resting heart rate, weight, and waist circumference. The odds ratios for a range of indicators of depression were higher for evening types (2.7-to 4.1-fold) and intermediate types (1.5-to 1.9-fold) than for morning types. Our results suggest that individuals having a preference for evening hours to carry out their daily activities are prone to depression. (Author correspondence: ilona.merikanto@helsinki.fi)

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Section: Discussionmentioning

confidence: 59%

Evening types are prone to depression

Merikanto

Lahti

Kronholm

et al. 2013

Chronobiology International

207

114

View full text Add to dashboard Cite

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“…These included plasma concentrations of the catecholamines noradrenaline (NA) and adrenaline, and their deaminated metabolite, 3,4-dihydroxyphenylethylglycol (DHPG), and 3,4-dihydroxyphenylacetic acid (DOPAC), a deaminated metabolite of dopamine (DA), urinary excretion of deaminated and methylated, non-deaminated metabolites of the monoamines, and MAO-B activity in blood platelets. In addition, we investigated changes in the release of prolactin, human growth hormone (hGH) and cortisol after acute moclobemide administration, since these hormones may be useful indicators of the effects of drugs on monoaminergic neurotransmission (Checkley, 1980;Koulu, 1986).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of monoamine oxidase by moclobemide: effects on monoamine metabolism and secretion of anterior pituitary hormones and cortisol in healthy volunteers.

Koulu

Scheinin

Kaarttinen

et al. 1989

Brit J Clinical Pharma

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1. Single oral doses (100, 200 and 300 mg) of moclobemide, a reversible inhibitor of monoamine oxidase (MAO) with predominant effects on the A‐ type of the enzyme, were administered to eight young, healthy male volunteers in a double‐blind, random‐order, placebo‐controlled study. The investigation was thereafter continued in an open fashion by administering a single 10 mg dose of the MAO‐B inhibitor deprenyl to the same subjects. 2. Deamination of catecholamines was powerfully and dose‐dependently inhibited by moclobemide, as evidenced by up to 40% decreases in the urinary excretion of deaminated catecholamine metabolites, corresponding increases in the excretion of non‐ deaminated, methylated metabolites, and up to 79% average decreases in the plasma concentration of 3,4‐dihydroxyphenylglycol (DHPG), a deaminated metabolite of noradrenaline (NA), and up to 75% average decreases in the plasma concentrations of 3,4‐dihydroxyphenylacetic acid (DOPAC), a deaminated metabolite of dopamine. The urinary excretion of 5‐hydroxyindoleacetic acid (5‐HIAA) was only slightly reduced. In contrast, deprenyl, in a dose which almost totally inhibited MAO‐B activity in blood platelets, did not appreciably affect the plasma concentrations of DHPG or DOPAC. 3. Due to the rapid, reversible, dose‐dependent and MAO‐A specific effect of moclobemide on plasma concentrations of DHPG, it is suggested that DHPG in plasma may be a useful indicator of the magnitude and duration of MAO‐A inhibition in man. 4. Sympatho‐adrenal function at rest was not significantly altered by moclobemide, as judged by unchanged plasma catecholamine concentrations and stable blood pressure and heart rate recordings. 5. Monoamine oxidase type B activity in blood platelets was slightly (less than 30%) and transiently inhibited after moclobemide. 6. The secretion of prolactin was dose‐dependently stimulated by moclobemide, whereas the plasma concentrations of growth hormone (hGH) and cortisol remained unchanged.

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“…fl-adrenoceptor blockage appears to enhance the GH response to most physiological stimuli, (Checkley, 1980) and also the ACTH response to amphetamine and hypoglycaemia Nakai et al, 1973) (Lien, Feruchel, Garsby, Sarantako & Grant, 1976;Shaar, Frederickson, Doninger & Jackson, 1977). These effects were blocked by naloxone (Shaar et al, 1977) and indeed reverse by naloxone administration alone (Bruni, van Vogt, Marshall & Meites, 1977;Gold, Redmond & Donabedian, 1978).…”

Section: Anxiolyticsmentioning

confidence: 95%

“…The administration of this drug on an acute and a chronic basis causes increased prolactin secretion (Jones et al, 1977). The administration of L-dopa, L-tryptophan and 5-hydroxytryptophan, the precursors of dopamine, noradrenaline and 5-hydroxytryptamine is associated with increased PRL secretion in man and in animals (Checkley, 1980). These drugs have been used as antidepressants but their efficacy is uncertain (Johnstone, 1980).…”

Section: Antidepressantsmentioning

confidence: 99%