Neuroendocrine markers of CNS drug effects.

Johnstone, E. C.; Ferrier, I. Nicol

doi:10.1111/j.1365-2125.1980.tb00497.x

Cited by 25 publications

(6 citation statements)

References 163 publications

(103 reference statements)

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“…Neuroleptics have been implicated in causing gonadotrophin and/or gonadal dysfunction either directly (Shader & DiMascio, 1970) or via hyperprolactinaemia (Glass et al 1975). The evidence for an effect of neuroleptics on LH and FSH is open to debate (Johnstone & Ferrier, 1980)-particularly in the case of chronic neuroleptic therapy (Beumont et al 1974 a), where it has been shown that prolactin levels tend to return to the normal range (De Rivera et al 1976;Huws & Groom, 1977). In the present study no difference in LH, LH episodic release, FSH or testosterone was noted between patients who had never received neuroleptics and those who had received substantial amounts in the past.…”

Section: Discussionmentioning

confidence: 99%

“…In view of the central role of the hypothalamopituitary axis in normal reproductive function, investigators now concentrate on measuring anterior pituitary secretion in schizophrenia. A similar approach is used to investigate other psychiatric illness, notably affective illness (Checkley, 1979), and to monitor the central effects of drugs (Sachar, 1978;Johnstone & Ferrier, 1980). The basic theory of such strategies has recently been reviewed (Checkley, 1980).…”

Section: Introductionmentioning

confidence: 99%

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Gonadotrophin secretion abnormalities in chronic schizophrenia

et al. 1982

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SynopsisLH, FSH, PRL and testosterone were estimated by radioimmunoassay in serial venous samples from 20 male chronic schizophrenic patients, 17 age-matched controls, 3 patients in remission from acute schizophrenia, and in single samples from age–sex matched populations. LH and FSH, but not testosterone or PRL, were significantly reduced in patients with chronic schizophrenia. There was an associated reduction in the frequency, but not amplitude, of LH secretory episodes in patients with chronic schizophrenia. No abnormalities of LH secretion were detected in those patients in remission from acute schizophrenia. Fourteen of the chronic schizophrenic patients were retested at a later date with similar results, except in the case of the few patients who had been started on neuroleptic medication. Some relationships were established between hormonal secretion and the clinical features of these patients. The possible significance of these findings is discussed in the context of the complex control of gonadotrophin secretion from the anterior pituitary and the natural history and nature of chronic schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gonadotrophin secretion abnormalities in chronic schizophrenia

et al. 1982

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“…Pituitary hormones:-b-adrenoceptor blockade enhances the growth hormone responses to most physiological stimuli and the ACTH responses to amphetamine and hypoglycaemia, suggesting that b-receptors have an inhibitory role in these responses (10).…”

Section: Central Action Of β β-Adrenoceptor Blocking Drugsmentioning

confidence: 99%

β-Adrenoceptor Blockade and Migraine

1982

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Except for propranolol, no other Beta-blocker has been studied thoroughly in the prophylaxis of migraine. Of those studied, propranolol, atenolol and timolol were shown to be useful in double-blind clinical trials. The mode, or even the site of action of these drugs in unknown. Possible mechanisms of action are peripheral vascular effects, a central action, 5-HT antagonism, an anxiolytic effect and a multifactorial action. The only common property of the successful drugs is lack of partial agonist activity and their profiles do not fully support any of the above hypotheses. Trials of drugs in the prophylaxis of migraine have in general been unsatisfactory due to the difficulty in controlling many variables. Beta-blockers with differing properties offer an opportunity to define the properties necessary for anti-migraine activity and perhaps shed light on the pathogenesis of migraine.

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“…The most important function of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland. As the brain is in constant endocrinal communication with the rest of the body, plasma samples can provide very useful information on brain functioning …”

Section: Link Between Bbb Transport Cns Diseases and Cns Drug Effectsmentioning

confidence: 99%

Translational aspects of blood–brain barrier transport and central nervous system effects of drugs: From discovery to patients

Lange

Hammarlund‐Udenaes

2015

Clin Pharma and Therapeutics

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The development of CNS drugs is associated with high failure rates. It is postulated that too much focus has been put on BBB permeability and too little on understanding BBB transport, which is the main limiting factor in drug delivery to the brain. An integrated approach to collecting, understanding, and handling pharmacokinetic-pharmacodynamic information from early discovery stages to the clinic is therefore recommended in order to improve translation to human drug treatment.

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Neuroendocrine markers of CNS drug effects.

Cited by 25 publications

References 163 publications

Gonadotrophin secretion abnormalities in chronic schizophrenia

Gonadotrophin secretion abnormalities in chronic schizophrenia

β-Adrenoceptor Blockade and Migraine

Translational aspects of blood–brain barrier transport and central nervous system effects of drugs: From discovery to patients

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