Neuroendocrine response to psychological performance testing

Folli, D.; Mutti, Antonio; Venne, Marie-Hélène; Berlin, Anita; Gerra, Gilberto; Cavazzini, S.; Maninetti, L.; Caccavari, R.; Vescovi, Pier Paolo

doi:10.1016/0306-4530(92)90005-r

Cited by 11 publications

(5 citation statements)

References 26 publications

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“…The catecholamine response to stress in children with anxiety disorder might be responsible for PRL inhibition during the task [68,69]. A similar PRL response to psychological performance testing with a significant reduction of plasma levels was reported in detoxified heroin addicts in relationship with NE and EPI increases [70].…”

Section: Discussionmentioning

confidence: 53%

Neuroendocrine Responses to Psychological Stress in Adolescents with Anxiety Disorder

Gerra¹,

Zaimovic²,

Zambelli³

et al. 2000

Neuropsychobiology

140

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Neurotransmitter-neuroendocrine and cardiovascular responses to the administration of a psychologically stressful mixed-model test (Mental Arithmetic, Stroop Color Word Interference Task, Trier Social Stress Test) were examined in 20 male peripubertal subjects affected by anxiety disorder (group A: 14 with generalized anxiety disorder, 6 with generalized anxiety disorder and separation anxiety disorder) and 20 junior school adolescents, matched for age, without overt psychological disorders (group B). Plasma levels of norepinephrine (NE), epinephrine (EPI), adrenocorticotropic hormone (ACTH), β-endorphin (β-EP), cortisol (CORT), growth hormone (GH), prolactin (PRL) and testosterone (Te) were measured immediately before the beginning of the tests and 30 min later at their end. Mean prestress values of GH, PRL, β-EP and ACTH were significantly higher in anxious subjects than in controls. There was no difference in NE, EPI, CORT and Te prestress levels in the two groups. After the psychological stress session NE, GH and Te concentrations increased significantly in anxious subjects (A), but not in controls. In contrast, β-EP and PRL decreased significantly during the psychological stress session in anxious subjects, and were unaffected by stress in the subjects without anxiety. No significant changes were found in ACTH, CORT and EPI during the challenge either in anxious subjects or in controls, which may be attributed to the late time of poststress blood sampling. In contrast to controls, heart rate and systolic blood pressure increased significantly in anxious subjects after psychological stress testing. Our data support the hypothesis that the hyperactivity of the noradrenergic system in response to stress is associated with anxiety disorders in adolescents and might influence the responses of GH and Te. High prestress basal values of stress hormones seem to be induced in anxious subjects by the anticipation of the task or by a persistent hyperactivity of the noradrenergic system. Further studies are needed to investigate in more detail the involvement of the HPA axis in anxious adolescents by a more refined resolution of time points of blood sampling.

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Section: Discussionmentioning

confidence: 53%

Neuroendocrine Responses to Psychological Stress in Adolescents with Anxiety Disorder

Gerra¹,

Zaimovic²,

Zambelli³

et al. 2000

Neuropsychobiology

140

View full text Add to dashboard Cite

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“…ACTH secretion was significantly attenuated in heroin-addicted individuals in comparison to healthy controls after a metyrapone challenge (Vescovi et al, 1990). Adrenergic system involvement was postulated when plasma cortisol levels declined throughout the session after IV clonidine administration in eight heroin abusers (Folli et al, 1992). Abstinent heroin-dependent subjects had higher basal levels of ACTH/cortisol than healthy controls (Gerra et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men

Goletiani

Mendelson

Sholar

et al. 2009

Pharmacology Biochemistry and Behavior

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Nalbuphine, a mixed mu-/kappa-opioid analgesic, may have potential as a new medication for the treatment of cocaine abuse. Kappa-opioid agonists functionally antagonize some abuse-related and locomotor effects of cocaine, and both kappa-selective and mixed mu-/kappa-opioids reduce cocaine self-administration by rhesus monkeys. Because cocaine's interactions with the hypothalamicpituitary-adrenal and (HPA) hypothalamic-pituitary-gonadal (HPG) axes may contribute to its reinforcing properties, we examined the effects of cocaine alone and in combination with nalbuphine. Neuroendocrine effects of a single dose of cocaine alone (0.2 mg/kg, IV), with nalbuphine (5 mg/70 kg, IV) + cocaine (0.2 mg/kg, IV) in combination were compared in seven adult men (ages 18-35) who met DSM-IV criteria for current cocaine abuse. Cocaine alone, and in combination with nalbuphine was administered on separate test days under placebo-controlled, double blind conditions. Cocaine stimulated ACTH, cortisol, and LH, whereas cocaine + nalbuphine in combination produced a smaller increase in ACTH, and decreased cortisol and LH. Thus it appears that nalbuphine attenuated cocaine's effects on ACTH, cortisol, and LH. These data are consistent with our earlier report that nalbuphine modestly attenuated cocaine's positive subjective effects, and that the subjective and cardiovascular effects of cocaine + nalbuphine in combination were not additive.

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“…However, a number of studies have evaluated possible short-term deleterious effects of withdrawing opioids from those who are physically dependent on them. In one study, opioid-dependent users who had abstained from heroin for at least 12 hr were given a 30-min RT test that consisted of 480 presentations of stimuli (the interval between stimuli varied from 2.5 to 5.0 s; Folli et al, 1992). Their performance on this sustained attention task, relative to a group of healthy controls, was not impaired.…”

Section: Effects Of Acute Opioid Withdrawal On Psychomotor and Cognit...mentioning

confidence: 99%

A review of the effects of opioids on psychomotor and cognitive functioning in humans.

Zacny¹

1995

Experimental and Clinical Psychopharmacology

179

112

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The literature on the effects of opioids on psychomotor and cognitive functioning in humans is evaluated. Some studies have examined the acute and chronic effects of various opioids on different subject populations. In addition, epidemiologic studies have examined the neuropsychological functioning and the risk of accidents for persons who have (or have had) opioids in their systemic circulation. In general, it appears that some opioids (mixed agonist–antagonists) more than others (morphine or codeine) impair psychomotor and cognitive functioning in healthy volunteers who have no history of opioid abuse. However, perhaps because of tolerance mechanisms, those who use opioids occasionally or habitually (patients with chronic pain or opioid abusers) are much less likely to have impairment of psychomotor or cognitive processes by opioids. Past research and present gaps in knowledge are used to make recommendations regarding worthwhile future directions in research.

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Neuroendocrine response to psychological performance testing

Cited by 11 publications

References 26 publications

Neuroendocrine Responses to Psychological Stress in Adolescents with Anxiety Disorder

Neuroendocrine Responses to Psychological Stress in Adolescents with Anxiety Disorder

Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men

A review of the effects of opioids on psychomotor and cognitive functioning in humans.

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