Neuroendocrine Carcinoma of the Prostate Gland

Hoof, Pamela; Tsai-Nguyen, Ginger; Paulson, Scott; Syed, Almas; Mora, Adam

doi:10.1080/08998280.2016.11929365

Cited by 7 publications

(10 citation statements)

References 9 publications

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“…These have confirmed the rarity of these tumours in the urinary tract; however, where it does exist, it is more likely to be found in the prostate than the ureter, with the ureter being an extremely rare site 5 15–18. This may be due to the high incidence of adenocarcinoma of the prostate, where prostatic NET can exist concomitantly following long-standing hormonal therapy, or in the context of therapeutic resistance in metastatic castration resistant prostate cancer 19–23. It has also been reported in association with dermatositis and polycythaemia 24.…”

Section: Discussionmentioning

confidence: 72%

“…Small cell NET of the prostate is commoner than the large cell counterpart, is often diagnosed at a later stage and shows very poor prognosis. The mainstay of treatment is a multimodal approach using platinum-based therapy, radiation, surgery where possible and in very advanced settings watchful waiting is an option, as no known curative therapies exist 19 25 26. This can also be said of ureteric NETs; both entities are poorly understood and very understudied due to their rarity.…”

Section: Discussionmentioning

confidence: 99%

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Incidental finding of a small cell neuroendocrine carcinoma of the ureter

Obi-Njoku¹,

Bell

Menon

et al. 2019

BMJ Case Rep

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The ureter is an extremely rare site for small cell neuroendocrine carcinoma. We present a case of this disease in a patient who presented without urological symptoms. The multidisciplinary team proposed nephroureterectomy (if fit) or watchful waiting as management. After discussion with the patient a decision in favour of watchful waiting was made. We report her case including a review of the literature, and emphasise that although small cell neuroendocrine carcinomas can be very aggressive, they can remain asymptomatic.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Incidental finding of a small cell neuroendocrine carcinoma of the ureter

Obi-Njoku¹,

Bell

Menon

et al. 2019

BMJ Case Rep

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“…Neuroendocrine small cell prostate cancer is rare, representing less than 1% of all cases [4] . They are more aggressive with early metastatic involvement of the lung and relatively limited PSA secretion in relation to the extent of disease [5] . This was the case in our patient with extensive involvement of the peripheral zone which was not reflected in the PSA value.…”

Section: Discussionmentioning

confidence: 99%

“…This was the case in our patient with extensive involvement of the peripheral zone which was not reflected in the PSA value. Due to limited evidence, the most effective treatment has yet to be determined [5] . Our patient was started on hormonal therapy which was effective in reducing the volume of prostate cancer and the PSA value.…”

Section: Discussionmentioning

confidence: 99%

Prostate cancer and sarcoma: Challenges of synchronous malignancies

Wali

Husain

Shah

et al. 2020

Radiology Case Reports

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Synchronous primary malignancies are a rare finding which can be difficult to diagnose. We present the case of a 57-year-old patient with a high prostate specific antigen who was found to have prostate cancer on subsequent magnetic resonance imaging. A skeletal metastasis was also identified at the time, although no osteoblastic activity or sclerosis was identified on skeletal scintigraphy or computed tomography, respectively. The patient was started on hormonal therapy and follow-up imaging revealed the prostate cancer to have reduced in volume. Despite this, the skeletal metastasis appeared unchanged on magnetic resonance imaging and an F18-choline positron emission tomography study was negative. A computed tomography guided bone biopsy was organized and this demonstrated metastatic leiomyosarcoma. As a result, an F18-fluorodeoxyglucose positron emission tomography study was performed to find the primary lesion which demonstrated a large malignant tumor within the calf. Subsequently, the patient was referred to a tertiary sarcoma unit. This case highlights the challenges involved in diagnosing and managing synchronous malignancies.

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“…A total of 6 cases in Evans's study had a history of ADT for prostate adenocarcinoma, but our case had no predisposing factor. LCNEC can present in young males and might have a genetic base (7,11). Animal model studies showed that prostate neuroendocrine cells could show a malignant transformation, as well (12).…”

Section: P63 Negativementioning

confidence: 99%

Large Cell Neuroendocrine Carcinoma of Prostate: A Rare Interesting Case and Literature Review

et al. 2017

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Prostate cancer (PC) is one of the most common forms of malignancies and the second cause of cancer death all around the world and the eight causes in Iran. The main portion of PC is adenocarcinoma, in some cases neuroendocrine differentiation occurs. Neuroendocrine prostate cancers (NePCs) incidence varies from 0.5% to 2% of all prostate cancers. Large cell neuroendocrine differentiation is very rare. In this study we presented a 71-year-old man with large cell neuroendocrine carcinoma of the prostate.

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Neuroendocrine Carcinoma of the Prostate Gland

Cited by 7 publications

References 9 publications

Incidental finding of a small cell neuroendocrine carcinoma of the ureter

Incidental finding of a small cell neuroendocrine carcinoma of the ureter

Prostate cancer and sarcoma: Challenges of synchronous malignancies

Large Cell Neuroendocrine Carcinoma of Prostate: A Rare Interesting Case and Literature Review

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