Neuroendocrine actions of nicotine and of exposure to cigarette smoke: Medical implications

Fuxé, Kjell; Andersson, Kurt; Eneroth, P.; Härfstrand, Anders; Agnati, Luigi F.

doi:10.1016/0306-4530(89)90054-1

Cited by 141 publications

(93 citation statements)

References 99 publications

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“…Em outro estudo, no quinto dia de lactação, ratas que receberam nicotina apresentavam níveis de prolactina nove vezes menor que as não tratadas, cessaram a produção de leite e a maioria dos filhotes morreu de inanição 41 . Evidências indicam que o efeito da nicotina na secreção de prolactina se deva à ativação de receptores nicotínicos de neurônios dopaminérgicos túbero-infundibulares, liberando dopamina como inibidor de prolactina 53 .…”

Section: Tabagismo E Lactaçãounclassified

Influência do tabagismo na fertilidade, gestação e lactação

Mello¹,

Pinto²,

Botelho³

2001

J. Pediatr. (Rio J.)

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Objective: to decribe the influence of smoking on different phases of the reproductive process, fecundation, pregnancy and lactation, drawing special attention to the mechanisms of action of the main toxic components found in cigarettes. To suggest prophylactic measures for environmental control and how to reduce children's exposure to tobacco smoke.Methods: nonsystematic literature review using MEDLINE database.Results: smoking has a negative effect on different phases of the reproduction process, by direct action of main toxic components, nicotine and carbon monoxide. Smoking reduces fertility, compromises the length of gestation and infant birthweight. Smoking mothers also have reduced breast milk production and shorter lactation, which affects infant weight gain through unclear mechanisms in which prolactin may probably be involved.Conclusions: smoking compromises reproductive function quality in different phases, acting mainly on intrauterine and extrauterine development of infants. Since during pregnancy and lactation women are in closer contact with health professionals, antismoking campaigns should be especially addressed to this period.J Pediatr (Rio J) 2001; 77 (4): 257-64: smoking, fertility, pregnancy, lactation, breast feeding. ResumoObjetivo: descrever a influência do tabagismo nas diferentes fases do processo reprodutivo, fecundação, gestação e lactação, destacando os mecanismos de ação dos principais componentes tóxicos do cigarro nestas fases. Sugerir medidas profiláticas de controle ambiental e de como reduzir a exposição da criança à fumaça do tabaco.Métodos: revisão bibliográfica não sistemática sobre os temas abordados, utilizando-se da base de dados do MEDLINE.Resultados: o tabagismo atua negativamente nas diferentes fases da reprodução, por ação direta de seus principais componentes tóxicos, a nicotina e o monóxido de carbono. Reduz a taxa de fertilidade, compromete a duração da gestação e o peso do concepto. Também diminui a produção de leite da nutriz fumante e o tempo de lactação, comprometendo o ganho de peso da prole, por mecanismos ainda não bem compreendidos, nos quais a prolactina pode estar envolvida.Conclusões: os efeitos do tabagismo comprometem a qualidade da função reprodutiva em diferentes fases, por atuar principalmente sobre o desenvolvimento do concepto, tanto na fase intra quanto na fase extra-uterino. Por ser um período de contato mais freqüente da mulher fumante com o profissional de saúde, a gestação e a lactação deveriam ser alvo especial de campanhas antitabágicas.J Pediatr (Rio J) 2001; 77 (4): 257-64: tabagismo, fertilidade, gestação, lactação, aleitamento materno. Influência do tabagismo na fertilidade, gestação e lactaçãoThe influence of smoking on fertility, pregnancy and lactation Paulo Roberto Bezerra de Mello 1 , Gilberto Rodrigues Pinto 2 , Clovis Botelho 3A fumaça do cigarro no ambiente é derivada de duas origens: fumaça central (FC) e fumaça periférica (FP). A fumaça central é formada quando o fumante traga o cigarro, é produzida com altas temperat...

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Section: Tabagismo E Lactaçãounclassified

Influência do tabagismo na fertilidade, gestação e lactação

Mello¹,

Pinto²,

Botelho³

2001

J. Pediatr. (Rio J.)

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“…It appears that smoking and manganese have an opposite effect on the serum prolactin concentration. A depressive effect of nicotine on serum prolactin concentration has been shown (23). It appears that chronic nicotine administration suppresses the pituitary prolactin secretion by increasing hypothalamic tuberoinfundibular dopaminergic activity (24).…”

Section: Discussionmentioning

confidence: 97%

Endocrine and immunologic markers in manganese alloy production workers

Ellingsen¹,

Haug²,

Gaarder³

et al. 2003

Scand J Work Environ Health

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“…For this reason in our previous researches we have studied exposure dosage to benzene, toluene and other aromatic hydrocarbons in Municipal Police employees of the city in question. Time weighted average (TWA) exposure to benzene (mean 10.7 and 3.6 µg/m 3 , respectively) and to toluene (mean 40.7 and 13.5 µg/m 3 , respectively) was significantly higher among traffic policemen than among indoor workers [15][16][17][18] . Since previous studies have already measured the environmental and biological levels in our working population and it is well known that traffic policemen's exposure dosage is significantly higher than controls, we didn't repeat the exposure dosage study in this work.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Urban Pollutants and Plasma Vasopressin in Traffic Policemen.

et al. 2004

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Abstract:Objectives) The aim of the present study is to investigate whether traffic policemen of a big city exposed to urban pollutants may be at risk of alterations on plasma vasopressin (VP) concentrations compared with a control group. Material and Methods) Out of a population of 395 Municipal Police employees, the subjects with the principal confounding factors were excluded from the study. Traffic policemen and control subjects were matched by sex, age and working life. Plasma VP levels were determined in 82 subjects: 41 traffic policemen (18 men, 23 women) and 41 control subjects (18 men, 23 women). Results) Mean of VP values were found significantly lower in traffic policemen than in the control group both in men (P=0.010) and in women (P=0.015). We found high correlation between VP values and working life in traffic policemen of male and female sex (r=0.7; r=0.6). Discussion) The authors hypothesise an effect on plasma VP levels in traffic policemen exposed to chemical and physical stressors, according to plasma VP levels modifications found by other authors in studies on animals and human subjects.

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Neuroendocrine actions of nicotine and of exposure to cigarette smoke: Medical implications

Cited by 141 publications

References 99 publications

Influência do tabagismo na fertilidade, gestação e lactação

Influência do tabagismo na fertilidade, gestação e lactação

Endocrine and immunologic markers in manganese alloy production workers

Exposure to Urban Pollutants and Plasma Vasopressin in Traffic Policemen.

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