Neurodevelopmental delay in normocephalic children with in utero exposure to Zika virus

Faiçal, Adriana Virgínia Barros; Oliveira, Juliana Cabral de; Oliveira, João; Almeida, Breno Lima de; Agra, Iluska Andrade; Alcântara, Luíz Carlos Júnior; Acosta, Angelina Xavier; Siqueira, Isadora Cristina de

doi:10.1136/bmjpo-2019-000486

Cited by 63 publications

(85 citation statements)

References 8 publications

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“…Faiçal et al 29 evaluated 29 normocephalic children with in utero exposure to Zika virus by the Bayley III. Ten (35%) infants presented neurodevelopment delay.…”

Section: Discussionmentioning

confidence: 99%

Neurodevelopment of Nonmicrocephalic Children, After 18 Months of Life, Exposed Prenatally to Zika Virus

et al. 2019

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The aim of this work was to evaluate the cognitive, language, and motor development, after 18 months of life, of nonmicrocephalic children born to mothers with Zika virus infection during pregnancy. Participants were 37 children aged 18-29 months divided into 2 groups: 17 nonmicrocephalic children born to mothers who had Zika virus infection during pregnancy (ZIKVG) and 20 nonmicrocephalic children with no maternal history of infection matched by sex and age (control group). A semistructured interview and the Bayley Scale of Infant and Toddler Development (Bayley III) were used for their evaluation. One child in the ZIKVG presented low cognitive score, the same in the control group. There were no statistical differences between the 2 groups regarding cognitive, language, and motor development. This sample, although small, showed that a significant proportion of nonmicrocephalic children exposed prenatally to Zika virus had normal development. A longer follow-up is necessary to observe if no other adverse outcomes will appear in the future.

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“…Faiçal et al 29 evaluated 29 normocephalic children with in utero exposure to Zika virus by the Bayley III. Ten (35%) infants presented neurodevelopment delay.…”

Section: Discussionmentioning

confidence: 99%

Neurodevelopment of Nonmicrocephalic Children, After 18 Months of Life, Exposed Prenatally to Zika Virus

et al. 2019

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“…Neonates born with congenital Zika syndrome (CZS) present severe microcephaly, eye loss, brain damage (including ventriculomegaly, intracranial calcifications, and skull collapse), congenital contractures, and hypertonia [ 6 , 7 ]. Healthy at birth not-infected children with in-uterus exposure to ZIKV may also develop psychomotor delays, poor reactions to external stimulation, generalized spastic dystonia, and other neurodevelopmental delays during childhood [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Perceptions and Emotional State of Mothers of Children with and without Microcephaly after the Zika Virus Epidemic in Rural Caribbean Colombia

Romero-Acosta

Marbán-Castro

Arroyo-Alvis

et al. 2020

Behavioral Sciences

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Zika virus (ZIKV) infection during pregnancy can cause neurological manifestations such as microcephaly. The aim of this study was to explore perceptions of ZIKV and mental health in women exposed to ZIKV during pregnancy in Colombia. This was a mixed-methods study based on structured interviews and psychological tests. Structured interviews were transcribed and analysed with Atlas Ti software. A grounded theory approach was applied. Quantitative analysis was performed with Statistical Package for Social Science, SPSS, V. 20. The study was approved by the Ethics Committee of the Universidad de Córdoba, Montería. Seventeen women participated in the study; nine of them were mothers of children with microcephaly. Maternal age ranged from 16 to 41 years old. The main themes discussed during interviews were: feelings, support, sources of information, and consequences on children’s health. Women with children affected by microcephaly showed worse mental health compared to women with normocephalic children. Maternal mental health worsened after 24 months from giving birth. Perceptions regarding disease severity and lack of knowledge were considered to affect maternal mental health. Social support and spirituality were key determinants for caregivers. Future research is needed to further study coping mechanisms and mental health outcomes over time by affected populations.

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“…Also, in the studies of the children born without microcephaly, it would be important to describe neuroimaging and postnatal head circumference measurements, which was not the case for all of them. 6,9,19,20 Previous evidence has shown that some of those children will develop microcephaly only postnatally, 3 and others may have typical neuroimaging findings, but without microcephaly. Thus, it is possible that those studies may be describing two different populations, both without microcephaly at birth, but possibly with different prognosis: one of infants with structural neurological abnormalities and the other of children without neuroanatomical damage.…”

Section: Discussionmentioning

confidence: 99%

“…Some of the studies describing the children born without microcephaly found suboptimal developmental scores, especially in the language domain, 9,10 but no comparison groups were described. Indeed, some of those children may have had a milder form of ZIKV-induced neurological impairment, but the socioeconomic context could be a cofounder for a lower language and cognitive development.…”

Section: Discussionmentioning

confidence: 99%

The neurodevelopmental spectrum of congenital Zika infection: a scoping review

Carvalho

Sales

Ventura

et al. 2020

Develop Med Child Neuro

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ABBREVIATIONS CZS Congenital Zika syndrome JBI Joanna Briggs Institute ZIKV Zika virus AIM To describe the standardized neurodevelopmental outcomes after the first year of life in children with congenital Zika syndrome (CZS) and those exposed to Zika virus (ZIKV) during fetal life, but without microcephaly at birth. METHOD This scoping review included observational studies about the standardized neurodevelopmental outcome in children with CZS or exposed to ZIKV, but without microcephaly, assessed after 12 months of age. The databases searched were MEDLINE/ Pubmed, LILACS, Scielo, Scopus, PsycINFO, CINAHL, and Embase. Risk of bias was assessed with the Joanna Briggs Institute Critical Appraisal Checklists. RESULTS Seventeen papers were included: 12 focused on children with CZS, four on children born without microcephaly, and one described both. Only one of the studies about CZS reported a child with microcephaly and typical development; the remainder described a severe pattern of global developmental delay and cerebral palsy. The prevalence of epilepsy was 74.6%. In the reports about children born without microcephaly, 6.9% to 8.7% had some domain with a score below À2 SD, and three children developed autism spectrum disorder. INTERPRETATION CZS is associated with severe global developmental delay and cerebral palsy after 1 year of age. In children born without microcephaly, although most have typical development, some may be at risk for impairments.

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Neurodevelopmental delay in normocephalic children with in utero exposure to Zika virus

Cited by 63 publications

References 8 publications

Neurodevelopment of Nonmicrocephalic Children, After 18 Months of Life, Exposed Prenatally to Zika Virus

Neurodevelopment of Nonmicrocephalic Children, After 18 Months of Life, Exposed Prenatally to Zika Virus

Perceptions and Emotional State of Mothers of Children with and without Microcephaly after the Zika Virus Epidemic in Rural Caribbean Colombia

The neurodevelopmental spectrum of congenital Zika infection: a scoping review

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