The neurodevelopmental spectrum of congenital Zika infection: a scoping review

Carvalho, Alessandra; Sales, Henrique; Ventura, Paloma; Gnoatto-Medeiros, Marina; Brites, Carlos; Lucena, Rita

doi:10.1111/dmcn.14675

Cited by 17 publications

(21 citation statements)

References 20 publications

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“…A síndrome congênita do Zika (CZS) foi recentemente descrita após o surto de microcefalia relacionada ao vírus no Brasil, entre 2015 e 2016 (Carvalho et al, 2020b). A descrição inicial incluía as seguintes características: microcefalia grave e crânio parcialmente colapsado; características típicas de neuroimagem, incluindo atrofia cerebral e calcificações subcorticais;…”

Section: Discussionunclassified

Prevalência da paralisia cerebral em neonatos de mães acometidas por Zika vírus: Uma revisão integrativa da literatura

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Filho

Sousa

2021

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Resumo Objetivo: Determinar, a partir de uma revisão integrativa da literatura, a prevalência de paralisia cerebral em neonatos com mães acometidas por Zika vírus no Brasil. Metodologia: Foram utilizados artigos na íntegra presentes nas bases dados Medical Publications (PubMed) e Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS). Para a busca, utilizaram-se os descritores: Infecção por Zika virus, Zika virus, recém-nascido e paralisia cerebral; obtidos de acordo com os Descritores de Ciências da Saúde (DeCS), tendo como operador booleano “E/ AND”. Posteriormente a aplicação dos critérios de inclusão definidos acima, nove artigos foram selecionados para revisão. Resultados: Em relação ao local de realização do estudo, 77,78% foram realizados na região Nordeste do país. Um dos estudos teve uma amostra de 538 indivíduos. A prevalência das paralisias cerebrais associadas à infecção congênita pelo zika vírus variou de 15,2% a 100%. Conclusão: Conclui-se que há uma alta prevalência de casos de neonatos de mães acometidas por ZIKV com paralisia cerebral. Estes dados reforçam a necessidade de serviços de intervenção precoce e planejamento de recursos para apoiar essas famílias em cuidados de saúde e ambientes comunitários no Brasil. Palavras-chave: Recém-nascido; Infecção por Zika vírus; Paralisia cerebral.

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Section: Discussionunclassified

Prevalência da paralisia cerebral em neonatos de mães acometidas por Zika vírus: Uma revisão integrativa da literatura

Cruz

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2021

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“…CZS is often associated with a global developmental delay [ 5 ]. Children with CZS may have different clinical manifestations such as microcephaly, muscle and joint contractures, epilepsy, central and peripheral nervous system lesions, as well as hearing, visual, and intellectual deficits [ 6 , 7 ]. All those manifestations are responsible for cognitive and motor development delays and behavioral disorders [ 1 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Children with CZS may have different clinical manifestations such as microcephaly, muscle and joint contractures, epilepsy, central and peripheral nervous system lesions, as well as hearing, visual, and intellectual deficits [ 6 , 7 ]. All those manifestations are responsible for cognitive and motor development delays and behavioral disorders [ 1 , 6 , 7 ]. Regarding the behavioral disorders, studies have described irritability from birth [ 7 , 8 ], while others have observed children with autism spectrum disorder (ASD) after exposure to Zika virus infection during pregnancy [ 8 , 9 ]; however, the background investigations of factors that may increase the predisposition to behavioral disorders in children with CZS is very restricted [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…All those manifestations are responsible for cognitive and motor development delays and behavioral disorders [ 1 , 6 , 7 ]. Regarding the behavioral disorders, studies have described irritability from birth [ 7 , 8 ], while others have observed children with autism spectrum disorder (ASD) after exposure to Zika virus infection during pregnancy [ 8 , 9 ]; however, the background investigations of factors that may increase the predisposition to behavioral disorders in children with CZS is very restricted [ 3 ]. Epidemiological studies have shown that most pregnant women exposed to ZIKV were from northeastern Brazil [ 1 ], with low per capita income and very poor housing and living conditions [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Family conditions such as maternal depression, domestic violence, and socioeconomic factors may directly affect the binomial mother-child and make children vulnerable to behavioral disorders [ 11 , 12 , 13 ]. Despite the increasing understanding of morphological alterations of fetal ZIKV infection and its developmental impairments [ 1 , 7 ], the long-term behavior implications of congenital ZIKV exposure and the interrelationship with unfavorable socioeconomic and family conditions remain poorly investigated. Such an approach may help to detect skills that were expected but not achieved and the children at risk of behavior disorder profiles.…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated with Behavioral Disorders in Children with Congenital Zika Syndrome and Their Families—A Cross-Sectional Study

Arrais

Maia

Rodrigues

et al. 2022

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The Zika virus was responsible for an outbreak between 2015 and 2016 in Brazil: an alarming public health problem of international relevance. The Congenital Zika Syndrome (CZS) is often associated with manifestations that are responsible for cognitive and motor development delays and behavioral disorders. Thus, we aimed to characterize the clinical-epidemiological and familial context of those children and to identify factors associated with the risk of behavioral disorders using the Survey of Well-Being of Young Children questionnaire (SWYC). In total, 52 children diagnosed with CZS were evaluated. Logistic regressions were employed to assess predictive variables for behavioral alteration. Eighteen (35%) of the children presented a risk of behavioral alteration. Children born normocephalic were 36-fold more likely to present behavioral alteration (95% CI: 3.82 to 337.92, p = 0.002). Children with hearing and visual impairments showed reduced risks. In total, 35% percent of families reported food insecurity and 21% were at risk for maternal depression. Our findings suggest better social interactions and conditions to externalize reactions for children with CZS born normocephalic. The continuous assessment of these children and families may identify conditions associated with behavioral alteration and psychosocial vulnerabilities that help in decision-making, therefore optimizing patient–family interactions.

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COVID-19 Pandemic and Infant Neurodevelopmental Impairment

et al. 2022

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ImportancePrimary studies proposed that aberrant maternal antiviral immunity and/or giving birth in quarantine, such as during the ongoing COVID-19 pandemic, may be associated with the risk of neurodevelopmental impairment (NDI) in offspring.ObjectivesTo evaluate the associations of birth and being raised during the COVID-19 pandemic with risk of NDI among infants and to assess the association of gestational exposure to SARS-CoV-2 with risk of NDI.Data SourcesPubMed, Web of Science, Scopus, Embase, and preprint servers were systematically searched from inception to March 25, 2022.Study SelectionStudies evaluating the neurodevelopment of infants born during the SARS-CoV-2 pandemic were included in this systematic review and meta-analysis. Studies using Ages and Stages Questionnaires, Third Edition (ASQ-3), were used for quantitative meta-analysis.Data Extraction and SynthesisFollowing the Preferred Reporting Items for Systematic Reviews and Meta-analyses, a random-effects model meta-analysis was used to pool the proportion and odds ratios (ORs) of overall NDI, as well as each developmental domain on ASQ-3 with the corresponding 95% CI.Main Outcomes and MeasuresThe primary outcome was the risk of overall NDI among infants screened during the pandemic vs prepandemic. The secondary outcome was the comparison of NDI by ASQ-3 domain among infants born to women with known gestational exposure to SARS-CoV-2 vs no exposure.ResultsA total of 8 studies were included, including 21 419 infants (11 438 screened in pandemic and 9981 in prepandemic period). NDI was present in 330 of 8992 infants (7%; 95% CI, 4%-10%) screened during the COVID-19 pandemic from January 2020 to January 2021. Among the pandemic cohort, the prevalence of NDI among infants with gestational exposure to SARS-CoV-2 was 77 of 691 (12%; 95% CI, 6%-18%). Compared with the prepandemic cohort (2015-2019), the pandemic cohort was more likely to have communication impairment (OR, 1.70; 95% CI, 1.37-2.11; P &lt; .001), without significant differences in other ASQ-3 domains (eg, gross motor, fine motor, personal-social, and problem-solving). In contrast, maternal SARS-CoV-2 infection was not associated with significant differences in any neurodevelopment domain in offspring, except for increasing the odds of fine motor impairment (OR, 3.46; 95% CI, 1.43-8.38; P &lt; .001).Conclusions and RelevanceIn this systematic review and meta-analysis examining the association between COVID-19 pandemic and the risk of NDI, findings suggest that overall neurodevelopment in the first year of life was not changed by either being born or raised during the SARS-CoV-2 pandemic or by gestational exposure to SARS-CoV-2. Interestingly, the first year of life during the COVID-19 pandemic, regardless of maternal infection, was significantly associated with the risk of communication delay among the offspring.

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The neurodevelopmental spectrum of congenital Zika infection: a scoping review

Cited by 17 publications

References 20 publications

Prevalência da paralisia cerebral em neonatos de mães acometidas por Zika vírus: Uma revisão integrativa da literatura

Prevalência da paralisia cerebral em neonatos de mães acometidas por Zika vírus: Uma revisão integrativa da literatura

Factors Associated with Behavioral Disorders in Children with Congenital Zika Syndrome and Their Families—A Cross-Sectional Study

COVID-19 Pandemic and Infant Neurodevelopmental Impairment

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