Neurocognitive profile of a man with Dandy–Walker malformation: Evidence of subtle cerebellar cognitive affective syndrome

Belser-Ehrlich, Janna; Lafo, Jacob; Mangal, Paul; Bradley, Margaret M.; Wicklund, Meredith; Bowers, Dawn

doi:10.1080/13854046.2019.1569724

Cited by 4 publications

(1 citation statement)

References 55 publications

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“…[10] Adult patients with late onset of symptoms related to the malformation have also been reported; the symptoms may include neural dysfunction manifesting as tremor, sensorimotor disorders, and in cases of Dandy-Walker variants, neurocognitive disorders such as psychosis and bipolar disorder. [11][12][13] The reason for the delayed diagnosis of DWM is not clear. Some suggest that a good communication between posterior fossa cyst membrane and the surrounding basal cisterns and distal pathways may explain the prolonged asymptomatic condition; the onset of symptoms in such cases may be attributed to age-related degeneration of the communicating channels.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Lateral ventricle pleomorphic xanthoastrocytoma concurrent with Dandy-Walker complex: A case report

Luo

Wang

et al. 2022

Medicine

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Introduction: Dandy-Walker complex and pleomorphic xanthoastrocytomas are both rare disease entities that typically manifest early in life and are associated with congenital etiological factors. Dandy-Walker complex is a cerebellar malformation associated with a series of anatomical changes. The disease onset is usually at birth or during infancy. Late onset in adulthood is uncommon. Pleomorphic xanthoastrocytoma is a rare WHO grade II astrocytic tumor affecting mainly young adults. Concomitant occurrence of Dandy-Walker complex and pleomorphic xanthoastrocytoma has not been previously reported.Patient concerns and diagnosis: A 30-year-old woman with a previous history of unconfirmed resected lateral ventricle meningioma presented with severe headache for 1 day. Imaging examination revealed a mass in the right lateral ventricle with heterogeneous signal patterns, changes in the posterior fossa corresponding to a Dandy-Walker variant, and mild hydrocephalus.Interventions and outcomes: Surgical complete resection of the mass was achieved. postoperative histopathological examination confirmed WHO grade II pleomorphic xanthoastrocytoma. Three years postsurgery, ventriculoperitoneal shunt was performed due to worsening of hydrocephalus. The patient has since remained symptom-free.Conclusion: This is the first report of concomitant occurrence of Dandy-Walker complex and pleomorphic xanthoastrocytoma. The association of neurological congenital malformation with intracranial neoplasms may be multifactorial, with underlying role of genetic mutations or chromosome alterations.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%

Lateral ventricle pleomorphic xanthoastrocytoma concurrent with Dandy-Walker complex: A case report

Luo

Wang

et al. 2022

Medicine

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Prospective investigation of cerebellar cognitive affective syndrome in a previously non-demented population of acute cerebellar stroke

Taskiran-Sag

Uyanik

Uyanık

et al. 2020

Journal of Stroke and Cerebrovascular Diseases

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A missing link in affect regulation: the cerebellum

Frazier

Hoffman

Popal

et al. 2022

Social Cognitive and Affective Neuroscience

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The cerebellum is one third the size of the cerebrum yet holds twice the number of neurons. Historically, its sole function was thought to be in the calibration of smooth movements through the creation and ongoing modification of motor programs. This traditional viewpoint has been challenged by findings showing that cerebellar damage can lead to striking changes in non-motor behavior, including emotional changes. In this manuscript, we review the literature on clinical and subclinical affective disturbances observed in individuals with lesions to the cerebellum. Disorders include pathological laughing and crying, bipolar disorder, depression, and mixed mood changes. We propose a theoretical model based on cerebellar connectivity to explain how the cerebellum calibrates affect. We conclude with actionable steps for future researchers to test this model and improve upon the limitations of past literature.

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Neurocognitive profile of a man with Dandy–Walker malformation: Evidence of subtle cerebellar cognitive affective syndrome

Cited by 4 publications

References 55 publications

Lateral ventricle pleomorphic xanthoastrocytoma concurrent with Dandy-Walker complex: A case report

Lateral ventricle pleomorphic xanthoastrocytoma concurrent with Dandy-Walker complex: A case report

Prospective investigation of cerebellar cognitive affective syndrome in a previously non-demented population of acute cerebellar stroke

A missing link in affect regulation: the cerebellum

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