Prospective investigation of cerebellar cognitive affective syndrome in a previously non-demented population of acute cerebellar stroke

Taskiran-Sag, Aslihan; Uyanik, Handan Uzuncakmak; Uyanık, Sadık Ahmet; Öztekin, Neşe

doi:10.1016/j.jstrokecerebrovasdis.2020.104923

Cited by 12 publications

(10 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is widely known that executive function is impaired in SCD [ 5 , 6 , 8 , 9 ]. Furthermore, our result is supported by reports that Luria’s fist-edge-palm test, a motor series task, is impaired in patients with stroke, limited only to the cerebellum [ 21 ]. Language repeat is a task of language function and verbal memory, in which participants listen to, retain, and recite a sentence.…”

Section: Discussionsupporting

confidence: 88%

Effects of Intensive Exercise on Cognitive Dysfunction in Patients With Pure Cerebellar Degeneration: A Single-Arm Pilot Study

Shimamoto¹,

Uchino²,

Mori³

et al. 2022

Ann Rehabil Med

View full text Add to dashboard Cite

Objective To clarify the profile of cognitive dysfunction and the effects of intensive exercise in spinocerebellar degeneration (SCD).Methods We enrolled 60 healthy controls and 16 patients with purely cerebellar type SCD without gait disturbance or organic changes other than cerebellar changes. To assess cognitive function, we evaluated the participants using the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Montreal Cognitive Assessment-Japanese (MoCA-J) at admission and after intensive exercise.Results Compared to the controls, SCD patients showed significant cognitive decline. As a result of intensive exercise, significant improvements in motor and cognitive functions were observed: the MMSE score improved from 27.7±1.9 to 29.0±1.3 points (p<0.001); the FAB score improved from 14.8±2.2 to 15.8±2.0 points (p=0.002); and the MoCA-J score improved from 24.6±2.2 to 26.7±1.9 points (p<0.001). For sub-scores, significant improvements were noted in serial 7, lexical fluency, motor series, and delayed recall.Conclusion Our study indicates that intensive exercise can be effective not only for motor dysfunction but also for cognitive dysfunction (Clinical Trial Registration No. UMIN-CTR: UMIN000040079).

show abstract

Section: Discussionsupporting

confidence: 88%

Effects of Intensive Exercise on Cognitive Dysfunction in Patients With Pure Cerebellar Degeneration: A Single-Arm Pilot Study

Shimamoto¹,

Uchino²,

Mori³

et al. 2022

Ann Rehabil Med

View full text Add to dashboard Cite

show abstract

“…Since the description of the CCAS in 1998 ( 22 ), several studies confirmed that almost all patients with acute cerebellar vascular lesion displayed significant cognitive impairments in a wide range of cognitive domains, corresponding to a CCAS ( 14 , 34 – 36 ) that mirrored the characteristics of Schmahmann's seminal report ( 22 ). However, the identification of a CCAS in those studies required the use of a full neuropsychological test battery, an assessment that requires over an hour in trained hands and is exhausting for acutely ill patients.…”

Section: Discussionmentioning

confidence: 91%

Cerebellar cognitive affective syndrome after acute cerebellar stroke

2022

View full text Add to dashboard Cite

IntroductionThe cerebellum modulates both motor and cognitive behaviors, and a cerebellar cognitive affective syndrome (CCAS) was described after a cerebellar stroke in 1998. Yet, a CCAS is seldom sought for, due to a lack of practical screening scales. Therefore, we aimed at assessing both the prevalence of CCAS after cerebellar acute vascular lesion and the yield of the CCAS-Scale (CCAS-S) in an acute stroke setting.Materials and methodsAll patients admitted between January 2020 and January 2022 with acute onset of a cerebellar ischemic or haemorrhagic first stroke at the CUB-Hôpital Erasme and who could be evaluated by the CCAS-S within a week of symptom onset were included.ResultsCerebellar acute vascular lesion occurred in 25/1,580 patients. All patients could complete the CCAS-S. A definite CCAS was evidenced in 21/25 patients. Patients failed 5.2 ± 2.12 items out of 8 and had a mean raw score of 68.2 ± 21.3 (normal values 82–120). Most failed items of the CCAS-S were related to verbal fluency, attention, and working memory.ConclusionA definite CCAS is present in almost all patients with acute cerebellar vascular lesions. CCAS is efficiently assessed by CCAS-S at bedside tests in acute stroke settings. The magnitude of CCAS likely reflects a cerebello-cortical diaschisis.

show abstract

“…8,13 A systematic review (in 2016) of 6 studies specifically on memory trajectory after stroke found conflicting results with decline (n=2), stability (n=3), and improvement (n=1) reported. 10 We, therefore, performed an updated review of the natural history and associated risk factors to include studies published since 2016 (Supplemental Methods [14][15][16][17][18][19][20][21][22][23][24][25][26][27] ). This identified 8 studies published since the previous review (n=262 total, mean age 51-69 years) with verbal episodic memory assessments and a wide range of follow-up times (3 months-8.2 years; Table 1).…”

Section: Memory Impairment After Stroke and Associated Factors Preval...mentioning

confidence: 99%

“…28 Consequently, some studies included subgroup analyses according to ApoE status. Studies reported improvement in verbal episodic memory (n=2, n=1 subgroup analysis of ApoE ε4 carriers), [19][20][21] no change (n=2, n=1 subgroup analysis of ApoE ε4 noncarriers) 14,21,22 and decline in both stroke patients and controls with no difference in rate of decline (n=1). 16 Others reported improvement in nonverbal memory 21 (n=3, n=1 subgroup analysis in ApoE ε4 noncarriers).…”

Section: Memory Impairment After Stroke and Associated Factors Preval...mentioning

confidence: 99%

“…Several studies (as reviewed above) show cognitive recovery in a substantial proportion of patients, at least in the first 12 to 18 months after stroke. [19][20][21]27,53 Mechanisms of recovery of function are, however, relatively understudied. A recent longitudinal study showed that fornix microstructural integrity of the fornix and greater gray matter volume within the cholinergic basal forebrain nuclei, but not cortical gray matter volumes, were associated with improvement in memory performance over time (Figure 4).…”

Section: Mechanisms Of Plasticity and Recoverymentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Recovery After Stroke: Memory

O’Sullivan

Galligan

et al. 2023

Stroke

View full text Add to dashboard Cite

Memory impairment occurs in over a third of patients after symptomatic stroke. Memory deficits rarely occur in isolation but are an important component of the poststroke cognitive syndrome because of the strong relationship with the risk of poststroke dementia. In this review, we summarize available data on impairment of episodic memory, with a particular emphasis on the natural history of memory impairment after stroke and the factors influencing trajectory informed by an updated systematic review. We next discuss the pathophysiology of memory impairment and mechanisms of both decline and recovery of function. We then turn to the practical issue of measurement of memory deficits after stroke, emerging biomarkers, and therapeutic approaches. Our review identifies critical gaps, particularly in studies of the natural history that properly map the long-term trajectory of memory and the associations with factors that modulate prognosis. Few studies have used advanced neuroimaging and this, in conjunction with other biomarker approaches, has the potential to provide a much richer understanding of the mechanisms at play and promising therapeutic avenues.

show abstract

Prospective investigation of cerebellar cognitive affective syndrome in a previously non-demented population of acute cerebellar stroke

Cited by 12 publications

References 39 publications

Effects of Intensive Exercise on Cognitive Dysfunction in Patients With Pure Cerebellar Degeneration: A Single-Arm Pilot Study

Effects of Intensive Exercise on Cognitive Dysfunction in Patients With Pure Cerebellar Degeneration: A Single-Arm Pilot Study

Cerebellar cognitive affective syndrome after acute cerebellar stroke

Cognitive Recovery After Stroke: Memory

Contact Info

Product

Resources

About