Neural Stem Cells and the Origin of Gliomas

Data driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancer

“…Breast cancer is a heterogeneous disease containing subtypes with different clinical behavior. It has been suggested that such distinct cancer subtypes may be derived from distinct progenitor cells which are arrested in their maturation [62][63][64][65][66]. When we analyzed the prognosis of subgroups we have observed an essential difference between bimodal parameters like ER, PgR, HER2 on the one hand and the continuous marker Ki67 on the other.…”

Epigenetic regulation of aging stem cells

“…In other hematopoietic malignancies, an initiating lesion in self-renewing stem cells may progress to malignancy when coupled with increased mutagenic events in the more rapidly expanding progenitor pool (Bonnet and Dick 1997;Cozzio et al, 2003;Rossi et al, 2008). Similarly, adult SVZ NSCs have been proposed as the origin of gliomas and astrocytomas (Lewis 1968;Vick et al, 1977;Holland et al, 2000;Sanai et al, 2005;Zhu et al, 2005;Jackson et al, 2006). Brain tumor cells share both anatomical location with SVZ niches and similar properties, including dependence on signaling pathways regulating normal NSC self-renewal Lim et al, 2007).…”

The culture of neural stem cells

“…The possibility that neural stem cells (NSCs) could be used to regenerate the brain gives their investigation extreme importance from a clinical perspective for treatment of diseases like Parkinson's [Sanberg, 2007]. Moreover, the hypothesis that errant growth of NSCs could give rise to brain tumors [Singh et al, 2004;Sanai et al, 2005; for reviews see Fomchenko and Holland, 2006;Galderisi et al, 2006] makes it even more compelling to investigate the biology of these cells.…”