Neural Differentiation of Human-Induced Pluripotent Stem Cells (hiPSc) on Surface-Modified Nanofibrous Scaffolds Coated with Platelet-Rich Plasma

Moazamiyanfar, Reza; Halabian, Raheleh; Ghollasi, Marzieh; Poormoghadam, Delaram; Entezari, Maliheh; Endorami, Seyed Ehsan

doi:10.1007/s11064-022-03584-2

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…The results proved that a nanofibrous PLLA scaffold could support the normal growth, proliferation, and differentiation of NSCs. In another study, Moazamiyanfar et al demonstrated that a PLLA scaffold covered with platelet-rich plasma showed low toxicity toward iPSCs and induced high expression of gene markers of neuronal cells in the differentiated iPSCs ( Moazamiyanfar et al, 2022 ). Furthermore, a PLLA-based scaffold loaded with stem cells could promote the restoration of neural network and gait function in the rat model of SCI ( Kaplan et al, 2020 ).…”

Section: Applications Of Plla-based Scaffolds In Peripheral Nerve And...mentioning

confidence: 99%

Recent advances in PLLA-based biomaterial scaffolds for neural tissue engineering: Fabrication, modification, and applications

Dai

Shao

et al. 2022

Front. Bioeng. Biotechnol.

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Repairing and regenerating injured neural tissue remains a worldwide challenge. Tissue engineering (TE) has been highlighted as a potential solution to provide functional substitutes for damaged organs or tissue. Among the biocompatible and biodegradable materials, poly-L-lactic-acid (PLLA) has been widely investigated in the TE field because of its tunable mechanical properties and tailorable surface functionalization. PLLA-based biomaterials can be engineered as scaffolds that mimic neural tissue extracellular matrix and modulate inflammatory responses. With technological advances, PLLA-based scaffolds can also have well-controlled three-dimensional sizes and structures to facilitate neurite extension. Furthermore, PLLA-based scaffolds have the potential to be used as drug-delivery carriers with controlled release. Moreover, owing to the good piezoelectric properties and capacity to carry conductive polymers, PLLA-based scaffolds can be combined with electrical stimulation to maintain stemness and promote axonal guidance. This mini-review summarizes and discusses the fabrication and modification techniques utilized in the PLLA-based biomaterial scaffolds for neural TE. Recent applications in peripheral nerve and spinal cord regeneration are also presented, and it is hoped that this will guide the future development of more effective and multifunctional PLLA-based nerve scaffolds.

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Section: Applications Of Plla-based Scaffolds In Peripheral Nerve And...mentioning

confidence: 99%

Recent advances in PLLA-based biomaterial scaffolds for neural tissue engineering: Fabrication, modification, and applications

Dai

Shao

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Osteogenic differentiation of pre-conditioned bone marrow mesenchymal stem cells with Nisin on modified poly-L-lactic-acid nanofibers

Sadraei

Ghollasi

Khakpai

et al. 2022

Regenerative Therapy

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Platelet-Rich Plasma for Heart Cell Regeneration Post-myocardial Infarction: A Propitious Therapeutic Approach

Navab,

Haward,

Chacko

et al. 2024

Cureus

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Neural Differentiation of Human-Induced Pluripotent Stem Cells (hiPSc) on Surface-Modified Nanofibrous Scaffolds Coated with Platelet-Rich Plasma

Cited by 3 publications

References 64 publications

Recent advances in PLLA-based biomaterial scaffolds for neural tissue engineering: Fabrication, modification, and applications

Recent advances in PLLA-based biomaterial scaffolds for neural tissue engineering: Fabrication, modification, and applications

Osteogenic differentiation of pre-conditioned bone marrow mesenchymal stem cells with Nisin on modified poly-L-lactic-acid nanofibers

Platelet-Rich Plasma for Heart Cell Regeneration Post-myocardial Infarction: A Propitious Therapeutic Approach

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