Neural Correlates of Topographic Mental Exploration: The Impact of Route versus Survey Perspective Learning

Mellet, Emmanuel; Bricogne, S.; Tzourio‐Mazoyer, Nathalie; Ghaëm, O.; Petit, Laurent; Zago, Laure; Etard, Olivier; Berthoz, Alain; Mazoyer, Bernard; Denis, Michel

doi:10.1006/nimg.2000.0648

Cited by 201 publications

(139 citation statements)

References 50 publications

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“…3A). The spatial layout of this mental imagery network consisted of bilateral intraparietal sulcus, supplementary motor area, occipital cortex, inferior temporal cortex, prefrontal cortex, premotor cortex, and fusiform gyrus, and is in accordance with the results of several previous imaging studies investigating the neural correlates of spatial imagery (Kosslyn et al, 1993(Kosslyn et al, , 1998Kawashima et al, 1995;Mellet et al, 1995Mellet et al, , 1996Mellet et al, , 1998Mellet et al, , 2000bCohen et al, 1996;Tagaris et al, 1997;Carpenter et al, 1999;Richter et al, 2000;Trojano et al, 2000;Lamm et al, 2001;Formisano et al, 2002;Sack et al, 2002bSack et al, , 2005. The modality-specific differences were mainly revealed in the auditory cortex (yellow indicates only active during auditory condition) and occipital regions/fusiform gyrus (light blue indicates only active during visual condition).…”

Section: Conventional Univariate Analysessupporting

confidence: 87%

Dynamic Premotor-to-Parietal Interactions during Spatial Imagery

Sack¹,

Jacobs²,

Martino³

et al. 2008

J. Neurosci.

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The neurobiological processes underlying mental imagery are a matter of debate and controversy among neuroscientists, cognitive psychologists, philosophers, and biologists. Recent neuroimaging studies demonstrated that the execution of mental imagery activates large frontoparietal and occipitotemporal networks in the human brain. These previous imaging studies, however, neglected the crucial interplay within and across the widely distributed cortical networks of activated brain regions. Here, we combined time-resolved eventrelated functional magnetic resonance imaging with analyses of interactions between brain regions (functional and effective brain connectivity) to unravel the premotor-parietal dynamics underlying spatial imagery. Participants had to sequentially construct and spatially transform a mental visual object based on either verbal or visual instructions. By concurrently accounting for the full spatiotemporal pattern of brain activity and network connectivity, we functionally segregated an early from a late premotor-parietal imagery network. Moreover, we revealed that the modality-specific information upcoming from sensory brain regions is first sent to the premotor cortex and then to the medial-dorsal parietal cortex, i.e., top-down from the motor to the perceptual pole during spatial imagery. Importantly, we demonstrate that the premotor cortex serves as the central relay station, projecting to parietal cortex at two functionally distinct stages during spatial imagery. Our approach enabled us to disentangle the multicomponential cognitive construct of mental imagery into its different cognitive subelements. We discuss and explicitly assign these mental subprocesses to each of the revealed effective brain connectivity networks and present an integrative neurobiological model of spatial imagery.

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Section: Conventional Univariate Analysessupporting

confidence: 87%

Dynamic Premotor-to-Parietal Interactions during Spatial Imagery

Sack¹,

Jacobs²,

Martino³

et al. 2008

J. Neurosci.

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“…Specifically, autobiographical memory tasks (42) and mental navigation of familiar routes (32,43,44) elicit activity in regions of posterior cingulate cortex, medial temporal cortex, and occipital cortex similar (or identical) to the regions presently of interest. Both these tasks encourage subjects to reactivate a previously experienced visualspatial context.…”

Section: Discussionmentioning

confidence: 99%

Neural substrates of envisioning the future

Szpunar

Watson

McDermott

2007

Proc. Natl. Acad. Sci. U.S.A.

681

504

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The ability to envision specific future episodes is a ubiquitous mental phenomenon that has seldom been discussed in the neuroscience literature. In this study, subjects underwent functional MRI while using event cues (e.g., Birthday) as a guide to vividly envision a personal future event, remember a personal memory, or imagine an event involving a familiar individual. Two basic patterns of data emerged. One set of regions (e.g., within left lateral premotor cortex; left precuneus; right posterior cerebellum) was more active while envisioning the future than while recollecting the past (and more active in both of these conditions than in the task involving imagining another person). These regions appear similar to those emerging from the literature on imagined (simulated) bodily movements. A second set of regions (e.g., bilateral posterior cingulate; bilateral parahippocampal gyrus; left occipital cortex) demonstrated indistinguishable activity during the future and past tasks (but greater activity in both tasks than the imagery control task); similar regions have been shown to be important for remembering previously encountered visual-spatial contexts. Hence, differences between the future and past tasks are attributed to differences in the demands placed on regions that underlie motor imagery of bodily movements, and similarities in activity for these two tasks are attributed to the reactivation of previously experienced visual-spatial contexts. That is, subjects appear to place their future scenarios in well known visual-spatial contexts. Our results offer insight into the fundamental and little-studied capacity of vivid mental projection of oneself in the future.autonoetic consciousness ͉ episodic future thought ͉ episodic memory ͉ functional MRI

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“…For example, tasks requiring memory of routes learned from the environment (Ghaem et al, 1997;Mellet et al, 2000) activate RSC and lesions, strokes, or tumors in this region produce amnesia including topokinetic disorientation (Valenstein et al, 1987;Rudge and Warrington, 1991;Takahashi et al, 1997). In view of the direct connections between RSC and dPCC and participation in common functions, the bCCOI analysis showed a restricted cingulate gyrus pattern of correlated voxels most prominently located in the posterior MCC and PCC, although there was an additional extension along the rostrum of the corpus callosum.…”

Section: Retrosplenial Cortexmentioning

confidence: 99%

Cytology and functionally correlated circuits of human posterior cingulate areas

2006

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Human posterior cingulate cortex (PCC) and retrosplenial cortex (RSC) form the posterior cingulate gyrus, however, monkey connection and human imaging studies suggest that PCC area 23 is not uniform and atlases mislocate RSC. We histologically assessed these regions in 6 postmortem cases, plotted a flat map, and characterized differences in dorsal (d) and ventral (v) area 23. Subsequently, functional connectivity of histologically guided regions of interest (ROI) were assessed in 163 [ 18 F] fluorodeoxyglucose human cases with PET. Compared to area d23, area v23 had a higher density and larger pyramids in layers II, IIIc, and Vb and more intermediate neurofilament-expressing neurons in layer Va. Coregisrtration of each case to standard coordinates showed that the ventral branch of the splenial sulci coincided with the border between d/v PCC at −5.4±0.17 cm from the vertical plane and +1.97±0.08 cm from the bi-commissural line. Correlation analysis of glucose metabolism using histologically guided ROIs suggested important circuit differences including dorsal and ventral visual stream inputs, interactions between the vPCC and subgenual cingulate cortex, and preferential relations between dPCC and the cingulate motor region. The RSC, in contrast, had restricted correlated activity with pericallosal cortex and thalamus. Visual information may be processed with an orbitofrontal link for synthesis of signals to drive premotor activity through dPCC. Review of the literature in terms of a PCC duality suggests that interactions of dPCC, including area 23d, orients the body in space via the cingulate motor areas, while vPCC interacts with subgenual cortex to process self-relevant emotional and non-emotional information and objects and self reflection.

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Neural Correlates of Topographic Mental Exploration: The Impact of Route versus Survey Perspective Learning

Cited by 201 publications

References 50 publications

Dynamic Premotor-to-Parietal Interactions during Spatial Imagery

Dynamic Premotor-to-Parietal Interactions during Spatial Imagery

Neural substrates of envisioning the future

Cytology and functionally correlated circuits of human posterior cingulate areas

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