Cytology and functionally correlated circuits of human posterior cingulate areas

Vogt, Brent A.; Vogt, Leslie J.; Laureys, Steven

doi:10.1016/j.neuroimage.2005.07.048

Cited by 445 publications

(399 citation statements)

References 77 publications

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“…Instead, PCC activity was negatively associated with individual differences in parasympathetic activity in the context of grief elicitation. Although unexpected, this is an exciting new result, as recent projection studies have demonstrated specific connectivity between the PCC and the sACC (Vogt et al, 2006), which projects to the autonomic nuclei in the brainstem (Neafsey et al, 1993).…”

Section: Discussionmentioning

confidence: 88%

“…Recent projection maps have shown that there are functional differences between the dorsal PCC (dPCC) and the ventral PCC (vPCC; Vogt et al, 2006). Vogt and colleagues propose a division between dPCC, which orients the body in space via the cingulate motor areas, and the vPCC, which interacts with sACC to process self-relevant emotional and nonemotional information and objects.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Baseline Vagal Tone Predicts BOLD Response during Elicitation of Grief

O’Connor¹,

Gündel

McRae

et al. 2007

Neuropsychopharmacol

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Previous studies of the relationship between autonomic and central nervous system activity using fMRI have primarily utilized cognitive, motor or conditioning tasks. The present study investigated the association between the regional brain activity during the evocation of grief and baseline parasympathetic activity. Eight right-handed women who had experienced the death of a loved one in the past 18 months were scanned during the presentation of personalized pictures and words that evoked grief and had a measure of baseline parasympathetic activity taken. Greater posterior cingulate cortex (PCC) activity was associated with lower parasympathetic activity (eg more arousal). Connectivity has been demonstrated between the ventral PCC (vPCC) and the subgenual ACC (sACC), which then projects to the autonomic nuclei. In the present study, functional connectivity analysis revealed a positive correlation between vPCC and sACC/orbitofrontal cortical activity. Additionally, bilateral cuneus and parahippocampus were associated with higher baseline parasympathetic tone, important to visual perception in emotional processing and episodic memory respectively. Future studies should compare differences between central and peripheral arousal in complicated and non-complicated grief.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Baseline Vagal Tone Predicts BOLD Response during Elicitation of Grief

O’Connor¹,

Gündel

McRae

et al. 2007

Neuropsychopharmacol

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“…2A). In view of the highly heterogeneous nature of the PCC (26,36), the fact that some regions play a generic role in memory, whereas a subregion in the RSC is selective for semantic word fluency, is not surprising. Similarly, interregional connectivity analyses yielded distinguished connectivity patterns during the two mnemonic conditions: elevated coactivation between the precuneus and ventral anterior cingulate during the semantic condition and between the precuneus and the left IPL during the episodic condition (Fig.…”

Section: Contributions Of Dmn Subcomponents To Specific Aspects Of Mementioning

confidence: 99%

Portraying the unique contribution of the default mode network to internally driven mnemonic processes

Shapira‐Lichter

Oren

Jacob

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Numerous neuroimaging studies have implicated default mode network (DMN) involvement in both internally driven processes and memory. Nevertheless, it is unclear whether memory operations reflect a particular case of internally driven processing or alternatively involve the DMN in a distinct manner, possibly depending on memory type. This question is critical for refining neurocognitive memory theorem in the context of other endogenic processes and elucidating the functional significance of this key network. We used functional MRI to examine DMN activity and connectivity patterns while participants overtly generated words according to nonmnemonic (phonemic) or mnemonic (semantic or episodic) cues. Overall, mnemonic word fluency was found to elicit greater DMN activity and stronger within-network functional connectivity compared with nonmnemonic fluency. Furthermore, two levels of functional organization of memory retrieval were shown. First, across both mnemonic tasks, activity was greater mainly in the posterior cingulate cortex, implying selective contribution to generic aspects of memory beyond its general involvement in endogenous processes. Second, parts of the DMN showed distinct selectivity for each of the mnemonic conditions; greater recruitment of the anterior prefrontal cortex, retroesplenial cortex, and hippocampi and elevated connectivity between anterior and posterior medial DMN nodes characterized the semantic condition, whereas increased recruitment of posterior DMN components and elevated connectivity between them characterized the episodic condition. This finding emphasizes the involvement of DMN elements in discrete aspects of memory retrieval. Altogether, our results show a specific contribution of the DMN to memory processes, corresponding to the specific type of memory retrieval.free recall | memory search | word fluency T he default mode network (DMN) is known to play a central role in internally based processes, including self-referential operations (1-4), internal mentation (5), and unconstrained thinking (6, 7). Additionally, during the past decades, the DMN has consistently been implicated in both semantic (8, 9) and episodic (10-13) memory processes. However, despite the fact that internal operations are inherent to many, if not all, mnemonic tasks, the unique contributions of the DMN to memory operations beyond its more general role in nonmnemonic internally based processes have not been sufficiently addressed thus far.One example of an internally based mnemonic process is mental search, which plays a central role in memory retrieval (14). Although a significant contribution of the DMN to memory search has been shown (12, 15), it is yet unclear whether this contribution merely reflects the DMN's involvement in nonspecific internal direction of attention or rather, a specific role for the DMN in mnemonic search processes. Direct comparison of DMN recruitment during memory search with its recruitment during nonmnemonic internal search operations may shed light on this matter. This questi...

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“…The CC is implicated in a diverse array of functions, such as emotion (George et al., 1995; Kross, Davidson, Weber, & Ochsner, 2009; Liotti et al., 2000; Rogers et al., 2004; Rolls, Grabenhorst, & Parris, 2008; Walter et al., 2008, 2009), movement (Beckmann, Johansen‐Berg, & Rushworth, 2009; Paus, 2001; Picard & Strick, 1996, 2001), self‐relevant assessment (Kelley et al., 2002; Vogt, Vogt, & Laureys, 2006), cognition (Luo et al., 2007; Pourtois et al., 2010; Sohn, Albert, Jung, Carter, & Anderson, 2007; Ursu, Clark, Aizenstein, Stenger, & Carter, 2009), memory (Maguire, 2001), visuospatial orientation (Vogt et al., 2006), navigation, imagination, and planning for the future (Vann, Aggleton, & Maguire, 2009). …”

Section: Introductionmentioning

confidence: 99%

Functional and anatomical connectivity‐based parcellation of human cingulate cortex

et al. 2018

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IntroductionHuman cingulate cortex (CC) has been implicated in many functions, which is highly suggestive of the existence of functional subregions.MethodsIn this study, we used resting‐state functional magnetic resonance imaging (rs‐fMRI) and diffusion tensor imaging (DTI) to parcellate the human cingulate cortex (CC) based on resting‐state functional connectivity (rsFC) patterns and anatomical connectivity (AC) patterns, to analyze the rsFC patterns and the AC patterns of different subregions, and to recognize whether the parcellation results obtained by the two different methods were consistent.ResultsThe CC was divided into six functional subregions, including the anterior cingulate cortex, dorsal anterior midcingulate cortex, ventral anterior midcingulate cortex, posterior midcingulate cortex, dorsal posterior cingulate cortex, and ventral posterior cingulate cortex. The CC was also divided into ten anatomical subregions, termed Subregion 1 (S1) to Subregion 10 (S10). Each subregion showed specific connectivity patterns, although the functional subregions and the anatomical subregions were internally consistent.ConclusionsUsing different model MRI images, we established a parcellation scheme, which is internally consistent for the human CC, which may provide an in vivo guide for subregion‐level studies and improve our understanding of this brain area at subregional levels.

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Cytology and functionally correlated circuits of human posterior cingulate areas

Cited by 445 publications

References 77 publications

Baseline Vagal Tone Predicts BOLD Response during Elicitation of Grief

Baseline Vagal Tone Predicts BOLD Response during Elicitation of Grief

Portraying the unique contribution of the default mode network to internally driven mnemonic processes

Functional and anatomical connectivity‐based parcellation of human cingulate cortex

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