Neural correlates of lower limbs proprioception: An fMRI study of foot position matching

Iandolo, Riccardo; Bellini, A.; Saiote, Catarina; Marre, I.; Bommarito, Giulia; Oesingmann, Niels; Fleysher, Lazar; Mancardi, Gianluigi; Casadio, Maura; Inglese, Matilde

doi:10.1002/hbm.23972

Cited by 40 publications

(59 citation statements)

References 100 publications

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“…The coin-shaped tactors also have limited contact area (10 mm diameter) that may not be able to elicit a robust response in muscle spindles, which should be preferentially excited by tendon vs. bone vibration. And whereas previous studies haves demonstrated a left side advantage in the discrimination of limb position, the perception of which relies mostly on muscle spindle activity (Symes et al 2010;Han et al 2013;Iandolo et al 2018), we found no corresponding left side advantage for vibrotactile discrimination thresholds. Our results therefore support the idea that the central processing of somatosensory stimuli related to vibrotactile perception differs from the central processing of somatosensory stimuli related to limb position and movement.…”

Section: Similarity Of Vibrotactile Discrimination Thresholds Acrosscontrasting

confidence: 99%

A two alternative forced choice method for assessing vibrotactile discrimination thresholds in the lower limb

Iandolo

Carè

Shah

et al. 2019

Somatosensory & Motor Research

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The development of an easy to implement, quantitative measure to examine vibration perception would be useful for future application in clinical settings. Vibration sense in the lower limb of younger and older adults was examined using the method of constant stimuli and the twoalternative forced choice paradigm. The focus of this experiment was to determine an appropriate stimulation site on the lower limb (tendon versus bone) to assess vibration threshold and to determine if the left and right legs have varying thresholds. Discrimination thresholds obtained at two stimulation sites in the left and right lower limbs showed differences in vibration threshold across the two ages groups, but not across sides of the body nor between stimulation sites within each limb. Overall, the method of constant stimuli can be implemented simply, reliably, and with minimal time. It can also easily be implemented with low-cost technology. Therefore, it could be a good candidate method to assess the presence of specific deep sensitivity deficits in clinical practice, particularly in populations likely to show the onset of sensory deficits.

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Section: Similarity Of Vibrotactile Discrimination Thresholds Acrosscontrasting

confidence: 99%

A two alternative forced choice method for assessing vibrotactile discrimination thresholds in the lower limb

Iandolo

Carè

Shah

et al. 2019

Somatosensory & Motor Research

Self Cite

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“…It is only recently that fMRI has been used to study position sense during actual limb motion but with evidences limited to the ankle joint (Iandolo et al, 2018) in healthy participants or the upper limb in poststroke subjects (Kenzie, Findlater, Pittman, Goodyear, & Dukelow, 2019). We also believe that complementing such information with the functional evidence coming from electrophysiological techniques could enrich the fMRI studies dramatically.…”

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confidence: 97%

Neural correlates of proprioceptive upper limb position matching

Marini

Zenzeri

Pippo

et al. 2019

Human Brain Mapping

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Proprioceptive information allows humans to perform smooth coordinated movements by constantly updating one's mind with knowledge of the position of one's limbs in space. How this information is combined with other sensory modalities and centrally processed to form conscious perceptions of limb position remains relatively unknown. What has proven even more elusive is pinpointing the contribution of proprioception in cortical activity related to motion. This study addresses these gaps by examining electrocortical dynamics while participants performed an upper limb position matching task in two conditions, namely with proprioceptive feedback or with both visual and proprioceptive feedback. Specifically, we evaluated the reduction of the electroencephalographic power (desynchronization) in the μ frequency band (8–12 Hz), which is known to characterize the neural activation associated with motor control and behavior. We observed a stronger desynchronization in the left motor and somatosensory areas, contralateral to the moving limb while, parietal and occipital regions, identifying association and visual areas, respectively, exhibited a similar activation level in the two hemispheres. Pertaining to the influence of the two experimental conditions it affected only movement's offset, and precisely we found that when matching movements are performed relying only on proprioceptive information, a lower cortical activity is entailed. This effect was strongest in the visual and association areas, while there was a minor effect in the hand motor and somatosensory areas.

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“…sensing (Iandolo et al 2018). Also, theta and alpha synchronization occurred in the cingulate region only during perturbation onset.…”

Section: Discussionmentioning

confidence: 93%

Transient visual perturbations boost short-term balance learning in virtual reality by modulating electrocortical activity

Peterson

Rios

Ferris

2018

Journal of Neurophysiology

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Immersive virtual reality can expose humans to novel training and sensory environments, but motor training with virtual reality has not been able to improve motor performance as much as motor training in real-world conditions. An advantage of immersive virtual reality that has not been fully leveraged is that it can introduce transient visual perturbations on top of the visual environment being displayed. The goal of this study was to determine whether transient visual perturbations introduced in immersive virtual reality modify electrocortical activity and behavioral outcomes in human subjects practicing a novel balancing task during walking. We studied three groups of healthy young adults (5 male and 5 female for each) while they learned a balance beam walking task for 30 min under different conditions. Two groups trained while wearing a virtual reality headset, and one of those groups also had half-second visual rotation perturbations lasting ~10% of the training time. The third group trained without virtual reality. We recorded high-density electroencephalography (EEG) and movement kinematics. We hypothesized that virtual reality training with perturbations would increase electrocortical activity and improve balance performance compared with virtual reality training without perturbations. Our results confirmed the hypothesis. Brief visual perturbations induced increased theta spectral power and decreased alpha spectral power in parietal and occipital regions and improved balance performance in posttesting. Our findings indicate that transient visual perturbations during immersive virtual reality training can boost short-term motor learning by inducing a cognitive change, minimizing the negative effects of virtual reality on motor training. NEW & NOTEWORTHY We found that transient visual perturbations in virtual reality during balance training can boost short-term motor learning by inducing a cognitive change, overcoming the negative effects of immersive virtual reality. As a result, subjects training in immersive virtual reality with visual perturbations have equivalent performance improvement as training in real-world conditions. Visual perturbations elicited cortical responses in occipital and parietal regions and may have improved the brain's ability to adapt to variations in sensory input.

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Neural correlates of lower limbs proprioception: An fMRI study of foot position matching

Cited by 40 publications

References 100 publications

A two alternative forced choice method for assessing vibrotactile discrimination thresholds in the lower limb

A two alternative forced choice method for assessing vibrotactile discrimination thresholds in the lower limb

Neural correlates of proprioceptive upper limb position matching

Transient visual perturbations boost short-term balance learning in virtual reality by modulating electrocortical activity

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