Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents

Bartholdy, Savani; O’Daly, Owen; Campbell, Iain C.; Barker, Gareth J.; Garavan, Hugh; Gowland, Penny A.; Heinz, Andreas; Martinot, Marie‐Laure Paillère; Smolka, Michael N.; Schmidt, Ulrike; Rapp, Michael A.; Artiges, Éric; Schneider, Sophia; Bach, C.; Paus, Tomáš; Barbot, Alexis; Barker, Gareth; Bokde, Arun L.W.; Vetter, Nora C.; Büchel, Christian; Cattrell, Anna; Constant, Patrick; Gowland, Penny; Crombag, Hans S.; Czech, Katharina; Dalley, Jeffrey W.; Decideur, Benjamin; Spranger, Tade Matthias; Ripley, Tamzin; Heym, Nadja; Flor, Herta; Sommer, Wolfgang H.; Fuchs, Birgit; Gallinat, Jürgen; Spanagel, Rainer; Kaviani, Mehri; Heinrichs, Bert; Heinz, Andreas; Subramaniam, Naresh; Jia, Tianye; Ihlenfeld, Albrecht; Ireland, James; Ittermann, Bernd; Conrod, Patricia J.; Banaschewski, Tobias; Jones, Jennifer; Klaassen, Arno; Lalanne, Christophe; Lanzerath, Dirk; Lawrence, Claire; Lemaître, Hervé; Desrivières, Sylvane; Mallik, Catherine; Mann, Karl; Mar, Adam; Martinez-Medina, Lourdes; Martinot, Jean‐Luc; Mennigen, Eva; Carvahlo, Fabiana Mesquita de; Schwartz, Yannick; Bruehl, Ruediger; Müller, Kathrin; Nees, Frauke; Nymberg, Charlotte; Lathrop, Mark; Robbins, Trevor W.; Pausová, Zdenka; Pentilla, Jani; Biondo, Francesca; Poline, Jean‐Baptiste; Hohmann, Sarah; Poustka, Luise; Millenet, Sabina; Fröhner, Juliane H.; Struve, Maren; Williams, Steve; Hübner, Thomas; Bromberg, Uli; Aydın, Semiha; Rogers, John; Romanowski, Alexander; Schmäl, Christine; Schmidt, Dirk; Ripke, Stephan; Arroyo, Mercedes; Schubert, Florian; Peña-Oliver, Yolanda; Fauth‐Bühler, Mira; Mignon, Xavier; Whelan, Robert; Speiser, Claudia; Fadai, Tahmine; Stephens, D.N.; Ströhle, Andreas; Paillère, Marie-Laure; Strache, Nicole; Theobald, David E.; Jurk, Sarah; Vulser, Hélène; Miranda, Rubén; Yacubian, Juliana; Frouin, Vincent; Genauck, Alexander; Parchetka, Caroline; Gemmeke, Isabel; Kruschwitz, Johann; Weiß, Katharina; Walter, Henrik; Feng, Jianfeng; Papadopoulos, Dimitri; Filippi, Irina; Ing, Alex; Ruggeri, Barbara; Xu, Bing; Macare, Christine; Chu, Congying; Hanratty, Éanna; Quinlan, Erin Burke; Robert, Guillaume; Schumann, Günter; Yu, Tao; Ziesch, Veronika; Stedman, Alicia

doi:10.1016/j.biopsych.2019.01.027

Cited by 29 publications

(24 citation statements)

References 51 publications

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“…This is supported by previous neuroimaging findings in IMAGEN showing that failed inhibitory control is a risk factor for future development of binge eating or purging, 51 and that have implicated shared neural circuitry, including the cognitive control system and the reward system, in the pathophysiology of ADHD and EDs. 52 Overall, these findings suggest that developing early interventions focusing on emotion regulation and impulsivity, which has recently been proposed as a transdiagnostic treatment across anxiety, depression, substance misuse, and EDs, 53 may be an effective strategy for prevention and treatment of EDs and comorbid disorders.…”

Section: Jama Network Open | Psychiatrymentioning

confidence: 94%

Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents

et al. 2020

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Key Points Question Do associations exist between disordered eating behaviors and other mental health disorders in adolescence, and if so, to what extent are those associations genetically predisposed? Findings Longitudinal assessments in this cohort study of a population-based sample of 1623 adolescents indicated that body mass index (BMI), neuroticism, impulse control, and addiction-related behaviors at 14 years of age were differentially associated with future disordered eating behaviors and symptoms of depression and generalized anxiety. Genetic analyses suggested etiologic overlaps between BMI, neuroticism, and attention-deficit/hyperactivity disorder with dieting, binge eating, and purging, respectively. Meaning Genetic and phenotypic assessments of BMI, impulse control problems, and personality may inform early and differential diagnoses of eating disorders.

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Section: Jama Network Open | Psychiatrymentioning

confidence: 94%

Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents

et al. 2020

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“…An extreme example of a disorder with impaired IC is attention deficit hyperactivity disorder (ADHD) [3]. Low IC is associated with a wide range of outcomes such as obesity, food choices, eating disorders, school performance, peer preferences, externalizing behaviors, aggression, prosocial behaviors, sexual debut, and use of drugs, alcohol, and tobacco [4][5][6][7][8][9][10][11][12]. Low IC may be one of the reasons why youth from low socioeconomic status (SES) and racial and ethnic minority groups engage in more risky behaviors, compared to high SES and majority youth [1,[13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Parental Education and Youth Inhibitory Control in the Adolescent Brain Cognitive Development (ABCD) Study: Blacks’ Diminished Returns

Assari

2020

Brain Sciences

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Background: Non-Hispanic Black (NHB) youth are at a higher risk of high-risk behaviors compared to non-Hispanic White (NHW) youth. Some of this racial gap is shown to be due to weaker effects of parental educational attainment on reducing the prevalence of behavioral risk factors such as impulsivity, substance use, aggression, obesity, and poor school performance for NHBs, a pattern called Minorities’ Diminished Returns. These diminishing returns may be due to lower than expected effects of parental education on inhibitory control. Aim: We compared NHW and NHB youth for the effect of parental educational attainment on youth inhibitory control, a psychological and cognitive construct that closely predicts high-risk behaviors such as the use of drugs, alcohol, and tobacco. Methods: This was a cross-sectional analysis that included 4188 youth from the Adolescent Brain Cognitive Development (ABCD) study. The independent variable was parental educational attainment. The main outcome was youth inhibitory control measured by the stop-signal task (SST), which was validated by parent reports on the Child Behavior Checklist (CBCL). Results: In race/ethnicity-stratified models, high parental educational attainment was associated with a higher level of inhibitory control for NHB than NHW youth. In the pooled sample, race/ethnicity showed a statistically significant interaction with parental educational attainment on youth inhibitory control suggesting that high parental educational attainment has a smaller boosting effect on inhibitory control for NHB than NHW youth. Conclusion: Parental educational attainment boosts inhibitory control for NHW but not NHB youth. To minimize the racial gap in youth brain development, we need to address societal barriers that diminish the returns of family economic and human resources, particularly parental educational attainment, for racial and ethnic minority youth. Social and public policies should address structural and societal barriers such as social stratification, segregation, racism, and discrimination that hinder NHB parents’ abilities to effectively mobilize their human resources and secure tangible outcomes for their developing youth.

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“…Interestingly, despite nonsignificant differences in stop-signal performance at baseline, augmented medial prefrontal and ACC activity on failed stop-signal trials predicted the onset of eating disorder (ED) behaviors at two-year, longitudinal follow-up (14).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa

Westwater

Mancini

Gorka

et al. 2020

Preprint

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Background: Binge-eating is a distressing, transdiagnostic eating disorder symptom associated with impulsivity, particularly in negative mood states. Neuroimaging studies of bulimia nervosa (BN) report reduced activity in fronto-striatal regions implicated in self-regulatory control. However, it remains unknown if negative affective states, including stress, impair self-regulation, and, if so, whether such self-regulatory deficits generalize to binge-eating in underweight individuals (i.e., the bingeing/purging subtype of anorexia nervosa; AN-BP). Methods:We determined the effect of acute stress on inhibitory control in 85 women (33 BN, 22 AN-BP, 30 matched controls). Participants underwent repeated functional MRI scanning, during performance of the stop-signal anticipation task, a validated measure of proactive (i.e., anticipation of stopping) and reactive (outright stopping) inhibition. Neural and behavioral responses to induced, psychological stress and a control task were evaluated on two separate days.Results: Women with BN had reduced proactive inhibition while prefrontal responses were increased in both AN-BP and BN. Reactive inhibition was neurally and behaviorally intact in both diagnostic groups. Both AN-BP and BN groups showed distinct, stress-induced changes in prefrontal activity during both proactive and reactive inhibition. However, task performance was not significantly affected by stress. Conclusions:These findings offer novel evidence of reduced proactive inhibition in BN, yet inhibitory control deficits did not generalize to AN-BP. While both groups showed altered neural responses during inhibition following stress, neither group demonstrated stress-induced performance deficits. As such, our findings counsel against a simplistic, stress-induced failure of regulation as a holistic explanation for binge-eating in these conditions.

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Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents

Cited by 29 publications

References 51 publications

Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents

Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents

Parental Education and Youth Inhibitory Control in the Adolescent Brain Cognitive Development (ABCD) Study: Blacks’ Diminished Returns

Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa

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