Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents

Robinson, Lauren; Zhang, Zuo; Jia, Tianye; Bobou, Marina; Roach, Anna; Campbell, Iain C.; Irish, Madeleine; Quinlan, Erin Burke; Tay, Nicole; Barker, Edward D.; Banaschewski, Tobias; Bokde, Arun L.W.; Grigis, Antoine; Garavan, Hugh; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean‐Luc; Stringaris, Argyris; Penttilä, Jani; Noort, Betteke van; Grimmer, Yvonne; Martinot, Marie‐Laure Paillère; Insensee, Corinna; Becker, Andreas; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Günter; Schmidt, Ulrike; Desrivières, Sylvane

doi:10.1001/jamanetworkopen.2020.26874

Cited by 28 publications

(28 citation statements)

References 63 publications

(103 reference statements)

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“…Furthermore any given context information is added. The stylistic and chronological developments of the portraits have been studied on the basis of art-historical criteria [ 1 , 2 , 92 ] and the inscriptions which often accompany the portraits, whereof 4.2% give exact years of death, as well as in-situ portraits [ 93 , 94 ].…”

Section: Methodsmentioning

confidence: 99%

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Three hundred years of Palmyrene history. Unlocking archaeological data for studying past societal transformations

Bobou

Romanowska

2021

PLoS ONE

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While archaeological sciences have made great advances over the last decades through combining archaeological evidence and natural sciences in order to push borders for the understanding of archaeological contexts, traditional archaeology still holds an immense latent potential. Such potential can be realized through baseline projects that pull together unexplored bodies of material culture and study these in detail in order to investigate their significance for the understanding of the human past. This paper presents such a large-scale baseline study and focuses on the presentation of the results emerging from the recently compiled corpus of more than 3700 funerary portraits stemming from one location in the ancient world, Roman Palmyra, an oasis city in the Syrian Desert. The analysis of the chronological development of the numerous portraits allows us to follow the fluctuations in the production of these portraits over approximately 300 years. Here we discuss and review the developments in connection with historical sources and discuss until now unknown events, which have emerged through the data analysis. The paper brings to the forefront the significance of social science baseline projects, which often do not receive enough attention or funding, but which in fact are fundamental for furthering our understanding of the human past and push borders for the directions in which we can take such studies in the future.

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Section: Methodsmentioning

confidence: 99%

“…These parameters are those well-established and widely used within classical archaeology and art historical approaches [i.e. 1 , 62 , 92 , 95 , 96 ]. Most of the stelai that can be associated with a known funerary monument come from underground tombs, for example, 1) stele with standing male and female [ 71 : p. 81, cat.…”

Section: Methodsmentioning

confidence: 99%

Three hundred years of Palmyrene history. Unlocking archaeological data for studying past societal transformations

Bobou

Romanowska

2021

PLoS ONE

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“…PGSs can be used to examine whether two traits are genetically related by associating the PGSs calculated for one trait with another trait. Our group (Abdulkadir et al, 2020) and others (Nagata et al, 2019; Robinson et al, 2020; Solmi, Mascarell, Zammit, Kirkbride, & Lewis, 2019) have successfully applied this method and reported that a BMI PGS and a schizophrenia PGS are associated with eating disorder symptoms (e.g., binge eating, fasting for weight loss, and body dissatisfaction) in the general population. However, a broader evaluation of PGSs indexing psychiatric and anthropometric/metabolic traits is warranted, as a GWAS on anorexia nervosa (AN) reported several significant genetic correlations with psychiatric, metabolic, and anthropometric traits (Duncan et al, 2017; Hübel et al, 2019; Watson et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores

Abdulkadir

Huebel

Herle

et al. 2021

Preprint

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Background. Eating disorder (ED) symptoms are prevalent in the general population, but their shared genetic underpinnings with psychiatric, metabolic, and anthropometric traits are not known. Here, we examined if polygenic scores (PGS) of traits associated with anorexia nervosa are also associated with adolescent ED symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC). Methods. We calculated PGS for 25 traits (16 psychiatric, 4 metabolic, and 5 anthropometric) and investigated their associations with eight ED symptoms, including behaviors such as fasting for weight loss and cognitions such as body dissatisfaction (n range=2,991-6,013). Results. Higher attention deficit hyperactivity disorder PGS and lower educational attainment PGS were associated with fasting for weight loss. Higher insomnia PGS was associated with increased body dissatisfaction. We found no evidence of an association between metabolic trait PGS and any ED symptom. Regarding anthropometrics, fat-free mass, fat mass, and body fat percentage PGSs, were positively associated with binge eating, excessive exercise, fasting for weight loss, body dissatisfaction, and weight and shape concern. Conclusions. ED symptoms are genetically associated with psychiatric and anthropometric, but not with metabolic traits. Our findings provide insights for future genetic research investigating why some individuals with ED symptoms progress to develop threshold EDs while others do not.

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“…Binge eating at 14 years was associated with future purging at 16 or 19 years. [9] In China, negative emotions are still associated with binge eating. Family relationships, stress, and social standards that bring negative emotions are all factors that influence binge eating among teenagers.…”

Section: Introductionmentioning

confidence: 99%

“…Fig 1.Time-Varying Associations and Outcomes of Disordered Eating Behaviors (DEBs) From 14 to 19 Years[9] …”

mentioning

confidence: 99%

Analysis of the Binge Eating in China

Feng

2021

E3S Web Conf.

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Binge Eating Disorder(BED) is a common disorder of eating behavior. It is estimated to affect 1- 3% of the total population. The research on binge eating is still in its early stages. The ubiquity of it made it important to explore the specific link between binge eating and negative emotions, especially among Chinese adolescents. BED is also common in China. There are different results of studies in other countries due to cultural, dietary, and psychological factors. This article explores the relationship between psychological factors (e.g., depression, anxiety, stress) and binge eating behavior among Chinese adolescents and how to deal with them.

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Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents

Cited by 28 publications

References 63 publications

Three hundred years of Palmyrene history. Unlocking archaeological data for studying past societal transformations

Three hundred years of Palmyrene history. Unlocking archaeological data for studying past societal transformations

Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores

Analysis of the Binge Eating in China

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