Neural Correlates of Emotion Processing in Typically Developing Children and Children of Diabetic Mothers

Cordòn, Ingrid M.; Georgieff, Michael; Nelson, Charles A.

doi:10.1080/87565640903265129

Cited by 12 publications

(7 citation statements)

References 66 publications

(82 reference statements)

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“…The suboptimal metabolic control during GD has been suggested to cause dysfunctions at the cortical level in the brain; this hypothesis is partly supported by previous studies carried out in humans and animals. [ 32 – 36 ] Our results suggest a mechanism that includes impaired neuronal function, since cVEPs are considered a proxy for neuron myelination (latencies) and visual acuity (amplitudes),[ 37 , 38 ] and are in agreement with studies reported by Brinciotti et al[ 18 , 39 ]…”

Section: Discussionsupporting

confidence: 90%

Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes

et al. 2018

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BackgroundOverweight, obesity, and gestational diabetes (GD) during pregnancy may negatively affect neurodevelopment in the offspring. However, the mechanisms are unclear and objective measures of neurodevelopment in infancy are scarce. We hypothesized that these maternal metabolic pathologies impair cortical visual evoked potentials (cVEPs), a proxy for visual and neuronal maturity.DesignThe PREOBE study included 331 pregnant women stratified into four groups; normal weight (controls), overweight, obesity, and GD (the latter including mothers with normal weight, overweight and obesity). In a subsample of the offspring at 3 months (n = 157) and at 18 months (n = 136), we assessed the latencies and amplitudes of the P100 wave from cVEPs and calculated visual acuity.ResultsAt 3 months of age, visual acuity was significantly poorer in offspring born to GD mothers. At 18 months of age, there were no differences in visual acuity but infants born to GD mothers had significantly longer latencies of cVEPs when measured at 15’, and 30’ of arc. The group differences at 30’ remained significant after confounder adjustment (mean [SD] 121.0 [16.0] vs. 112.6 [7.6] ms in controls, p = 0.007) and the most prolonged latencies were observed in offspring to GD mothers with concurrent overweight (128.9 [26.9] ms, p = 0.002) and obesity (118.5 [5.1] ms, p = 0.020).ConclusionsInfants born to mothers with GD, particularly those with concurrent overweight or obesity, have prolonged latencies of visual evoked potentials at 18 months of age, suggesting that this maternal metabolic profile have a long lasting, non-optimal, effect on infants´ brain development.

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Section: Discussionsupporting

confidence: 90%

Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes

et al. 2018

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“…5 In relation to the CNS, previous studies have noted that infants of diabetic mothers have impairments in habituation to stimulation and emotional processing. 6,7 In a study by Gonzalez-Gonzalez et al 6 on fetuses with maternal pregestational diabetes, it was observed that the fetuses in the diabetic group had difficulty in habituating to vibroacoustic stimulation and their results were similar to an earlier study by Doherty et al 8 Additionally, they also noted that high levels of maternal glycated hemoglobin (HbA 1c ) in any of the trimesters of pregnancy had significantly negative correlation with infant recordings of habituation ability. It has also been reported that neonates of mothers with type 1 diabetes showed a higher percentage of immature and disorganized EEG patterns and excessive transient sleep waves, which are associated with brain injury and cognitive deficits.…”

Section: Introductionsupporting

confidence: 55%

Studying the Effect of Maternal Pregestational Diabetes on Fetal Neurodevelopment Using Magnetoencephalography

et al. 2020

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Background. Developmental origin of health and disease states that an adverse intrauterine environment can lead to different diseases in later life. In this study, we aimed to explore the effect of maternal pregestational diabetes on the fetal brain activity using magnetoencephalography (MEG). Methods. Forty participants were included in an observational study with 9 type 1 and 19 type 2 diabetic pregnant women compared with data from 12 nondiabetic participants. Spontaneous fetal MEG signals were recorded and power spectral density was computed in 4 standard frequency bands. Group differences were investigated using analysis of covariance. Results. Our results showed that type 1 group was significantly different ( P < .05) from the reference group for 3 of the 4 brain activity frequency bands, while in type 2 group, 2 bands exhibited this trend. When dichotomized based on the maternal glycemic control, significant differences in all bands were observed between the poor-control and reference groups. Conclusion. The fetal background brain activity parameters appear to be altered in diabetic pregnancy in comparison with the reference low-risk group. The study showed that maternal pregestational diabetes could potentially influence in utero neurodevelopment.

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“…A similar and likely analogous waveform was modulated by facial affect in a sample of institutionalized Romanian children in this age range (Parker et al, 2005). Further, a similar component observed in 3- and 4-year-old children of diabetic mothers, identified as the positive-going aspect of the N1-P2 complex, was found to vary in latency across affective facial expressions (Cordon, Georgieff, & Nelson, 2009).…”

mentioning

confidence: 77%

Affective Facial Expression Processing in 15-Month-Old Infants Who Have Experienced Maltreatment

Curtis

Cicchetti

2013

Child Maltreat

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This study examined the neural correlates of facial affect processing in 15 month-old maltreated and nonmaltreated infants. Event-related potentials (ERPs) were elicited while infants passively viewed standardized pictures of female models posing angry, happy, and neutral facial expressions. Differences between maltreated (N=25) and nonmaltreated (N=20) infants were observed on three ERP components: P1, P260, and Nc. Compared to nonmaltreated infants, maltreated infants had greater P1 amplitude in response to happy facial affect while nonmaltreated infants had greater P1 amplitude in response to angry faces compared to the maltreated infants. Within the maltreated group, P1 was greater in response to happy relative to angry facial affect, whereas for nonmaltreated infants the opposite pattern was observed, with greater P1 amplitude in response to angry affect relative to happy. For the P260, nonmaltreated infants had greater amplitude than maltreated infants in response to happy facial affect. P260 amplitude was greater in response to angry relative to happy facial affect within the maltreated group. Amplitude of the Nc component in response to angry facial affect was greater in the nonmaltreated infants relative to the maltreated infants. Further, within the maltreated group, Nc was greater for happy compared to angry faces. In contrast, within the nonmaltreated group, Nc amplitude was greater in response to angry versus happy faces. The results provided further support for the hypothesis that the experience of maltreatment and the predominantly negative emotional tone in maltreating families alters the functioning of neural systems associated with the processing facial emotion. These results exemplify the importance of early preventive interventions focused on emotion for children who have experienced maltreatment early in life.

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Neural Correlates of Emotion Processing in Typically Developing Children and Children of Diabetic Mothers

Cited by 12 publications

References 66 publications

Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes

Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes

Studying the Effect of Maternal Pregestational Diabetes on Fetal Neurodevelopment Using Magnetoencephalography

Affective Facial Expression Processing in 15-Month-Old Infants Who Have Experienced Maltreatment

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