Neural Correlates of Developmental Speech and Language Disorders: Evidence from Neuroimaging

Liégeois, F; Mayes, Angela; Morgan, Angela

doi:10.1007/s40474-014-0019-1

Cited by 42 publications

(38 citation statements)

References 61 publications

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“…Lastly, the cerebellum has been hypothesized to be involved in CAS by the abovementioned DIVA model, as an alteration in feed-forward mechanisms of speech control (Guenther, 2001, Maassen, 2002). Involvement of both supplementary motor areas and cerebellum agrees with hypotheses on altered motor planning related to speech in CAS (Liégeois et al, 2014, Guenther, 2001). …”

Section: Discussionsupporting

confidence: 86%

“…Moreover, our results showed that the altered frontotemporal network extended to a more posterior connection in the postcentral gyrus (parietal lobe). Although no primary oromotor region was involved, this finding supports a sensory (postcentral) component contribution in the pathogenesis of CAS, as hypothesized in studies on brain lesions (Liégeois et al, 2014) or in theoretical models for CAS, such as the DIVA model (Guenther, 2001). …”

Section: Discussionsupporting

confidence: 74%

“…Liégeois and Morgan (2012) reported that 60% of children with CAS have normal structural MRI, but quantitative approaches suggested microscopic abnormalities of white or grey matter (Liégeois et al, 2014). Our data, for the first time, provide evidence of connectivity anomalies in children with CAS across specific brain regions involved in speech/language function.…”

Section: Resultsmentioning

confidence: 99%

“…epilepsy, brain lesion, metabolic deficits) or can present as an idiopathic disorder. To date, the aetiology and underlying neural mechanisms of idiopathic CAS remain largely unknown (Liégeois and Morgan, 2012, Liégeois et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Neuroanatomical correlates of childhood apraxia of speech: A connectomic approach

Fiori

Guzzetta

Mitra

et al. 2016

NeuroImage: Clinical

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Childhood apraxia of speech (CAS) is a paediatric speech sound disorder in which precision and consistency of speech movements are impaired. Most children with idiopathic CAS have normal structural brain MRI. We hypothesize that children with CAS have altered structural connectivity in speech/language networks compared to controls and that these altered connections are related to functional speech/language measures.Whole brain probabilistic tractography, using constrained spherical deconvolution, was performed for connectome generation in 17 children with CAS and 10 age-matched controls. Fractional anisotropy (FA) was used as a measure of connectivity and the connections with altered FA between CAS and controls were identified. Further, the relationship between altered FA and speech/language scores was determined.Three intra-hemispheric/interhemispheric subnetworks showed reduction of FA in CAS compared to controls, including left inferior (opercular part) and superior (dorsolateral, medial and orbital part) frontal gyrus, left superior and middle temporal gyrus and left post-central gyrus (subnetwork 1); right supplementary motor area, left middle and inferior (orbital part) frontal gyrus, left precuneus and cuneus, right superior occipital gyrus and right cerebellum (subnetwork 2); right angular gyrus, right superior temporal gyrus and right inferior occipital gyrus (subnetwork 3). Reduced FA of some connections correlated with diadochokinesis, oromotor skills, expressive grammar and poor lexical production in CAS.These findings provide evidence of structural connectivity anomalies in children with CAS across specific brain regions involved in speech/language function. We propose altered connectivity as a possible epiphenomenon of complex pathogenic mechanisms in CAS which need further investigation.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroanatomical correlates of childhood apraxia of speech: A connectomic approach

Fiori

Guzzetta

Mitra

et al. 2016

NeuroImage: Clinical

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“…[1][2][3] Rapid advances in discovery are anticipated over the coming decade, unraveling the complex genetic, environmental, and neural origins. [23][24][25][26][27][28][29] What is the clinical course?…”

Section: Sources and Selection Criteriamentioning

confidence: 99%

Identifying and managing common childhood language and speech impairments

Reilly

McKean

Morgan

et al. 2015

BMJ

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Interventions for childhood apraxia of speech

Morgan

Murray

Liégeois

2018

Cochrane Database of Systematic Reviews

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Background Childhood apraxia of speech (CAS) affects a child's ability to produce sounds and syllables precisely and consistently, and to produce words and sentences with accuracy and correct speech rhythm. It is a rare condition, affecting only 0.1% of the general population. Consensus has been reached that three core features have diagnostic validity: (1) inconsistent error production on both consonants and vowels across repeated productions of syllables or words; (2) lengthened and impaired coarticulatory transitions between sounds and syllables; and (3) inappropriate prosody (ASHA 2007). A deficit in motor programming or planning is thought to underlie the condition. This means that children know what they would like to say but there is a breakdown in the ability to programme or plan the fine and rapid movements required to accurately produce speech. Children with CAS may also have impairments in one or more of the following areas: non-speech oral motor function, dysarthria, language, phonological production impairment, phonemic awareness or metalinguistic skills and literacy, or combinations of these. High-quality evidence from randomised controlled trials (RCTs) is lacking on interventions for CAS. Objectives To assess the efficacy of interventions targeting speech and language in children and adolescents with CAS as delivered by speech and language pathologists/therapists. Search methods We searched CENTRAL, MEDLINE, Embase, eight other databases and seven trial registers up to April 2017. We searched the reference lists of included reports and requested information on unpublished trials from authors of published studies and other experts as well as information groups in the areas of speech and language therapy/pathology and linguistics. Selection criteria RCTs and quasi-RCTs of children aged 3 to 16 years with CAS diagnosed by a speech and language pathologist/therapist, grouped by treatment types. Data collection and analysis Two review authors (FL, AM) independently assessed titles and abstracts identified from the searches and obtained full-text reports of all potentially relevant articles and assessed these for eligibility. The same two authors extracted data and conducted the 'Risk of bias' and GRADE assessments. One review author (EM) tabulated findings from excluded observational studies (Table 1). 1 Interventions for childhood apraxia of speech (Review)

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Neural Correlates of Developmental Speech and Language Disorders: Evidence from Neuroimaging

Cited by 42 publications

References 61 publications

Neuroanatomical correlates of childhood apraxia of speech: A connectomic approach

Neuroanatomical correlates of childhood apraxia of speech: A connectomic approach

Identifying and managing common childhood language and speech impairments

Interventions for childhood apraxia of speech

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