Neural-Activity-Dependent Release of S100B from Astrocytes Enhances Kainate-Induced Gamma Oscillations<i>In Vivo</i>

Sakatani, Seiichi; Seto‐Ohshima, Akiko; Shinohara, Yuta; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Itohara, Shigeyoshi; Hirase, Hajime

doi:10.1523/jneurosci.3693-08.2008

Cited by 100 publications

(87 citation statements)

References 62 publications

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“…4a). 23,24 . As could be expected, immunostaining with an antibody directed against S100β revealed numerous immunoreactive astrocytes in dorsal NVsnpr (Supplementary Fig.…”

Section: Inactivation Of Astrocytes Prevents Neuronal Burstingmentioning

confidence: 99%

“…So we tested whether blocking extracellular S100β activity with a local application of an S100β-subunit monoclonal antibody (40-80 µg/ml) 24 prevented bursting induced by NMDA applications or sensory fibers stimulation. To insure that the antibody interferes with the Ca 2+ binding ability of S100β, we used ITC.…”

Section: Inactivation Of Astrocytes Prevents Neuronal Burstingmentioning

confidence: 99%

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An astrocyte-dependent mechanism for neuronal rhythmogenesis

et al. 2015

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ABSTRACT:Communication between neurons rests on their capacity to change their firing pattern to encode different messages. For several vital functions, such as respiration and mastication, neurons need to generate a rhythmic firing pattern. Here we show in the rat trigeminal sensori-motor circuit for mastication that this ability depends on regulation of the extracellular Ca 2+ concentration ([Ca 2+ ] e ) by astrocytes. In this circuit, astrocytes respond to sensory stimuli that induce neuronal rhythmic activity, and their blockade with a Ca 2+ chelator prevents neurons from generating a rhythmic bursting pattern.This ability is restored by adding S100β, an astrocytic Ca 2+ -binding protein, to the extracellular space, while application of an anti-S100β antibody prevents generation of rhythmic activity. These results indicate that astrocytes regulate a fundamental neuronal property: the capacity to change firing pattern. These findings may have broad implications for many other neural networks whose functions depend on the generation of rhythmic activity.

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“…4a). 23,24 . As could be expected, immunostaining with an antibody directed against S100β revealed numerous immunoreactive astrocytes in dorsal NVsnpr (Supplementary Fig.…”

Section: Inactivation Of Astrocytes Prevents Neuronal Burstingmentioning

confidence: 99%

Section: Inactivation Of Astrocytes Prevents Neuronal Burstingmentioning

confidence: 99%

An astrocyte-dependent mechanism for neuronal rhythmogenesis

et al. 2015

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“…Other authors revealed that in the hippocampus of an epileptic model an excitation of astrocytic Glu metabotropic receptors type II (mGluR3) results in S100β secretion from astrocytes and in consequence this leads to a decrease in the number of these glial cells with S100β expression. The protein also shows a neuroprotective effect and increases the survival of specific neuronal populations (Sakatani et al 2008). Phenotypic astroglial alterations in ARC indicate that the BBB is permeable for CAP derived from habanero pepper fruits after intragastric administration to rats.…”

Section: Discussionmentioning

confidence: 99%

Immunoreactivity of arcuate nucleus astrocytes in rats after intragastric administration of habanero peppers (Capsicum Chinese Jacq.)

Rycerz¹,

Krawczyk²,

Jaworska-Adamu³

et al. 2016

Polish Journal of Veterinary Sciences

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Habanero pepper fruits contain capsaicin (CAP) characterised by a spicy taste. Astrocytes express vanilloid receptor (TRPV1), which interacts with cannabinoids including CAP. Only a few studies revealed that CAP leads to alterations of the arcuate nucleus (ARC) structures. The aim of this study was to analyse the GFAP (GFAP-IR) and S100β (S100β-IR) immunoreactive astrocytes of ARC in adult rats after intragastric administration of habanero pepper fruits. Adult, Wistar rats received a peanut oil -control group (C) -and oil suspension of habanero pepper fruits at a dose of 0.08 g dm/kg b.w. for 7 days -E1 group -and 28 days -E2 group. After euthanasia, the brains were embedded in paraffin blocks using a routine histological technique. Frontal slices of ARC were immunohistochemically stained for GFAP and S100β using specific antibodies in the peroxidase-antiperoxidase method. Astrocytes of ARC were morphologically and morphometrically analysed under a light microscope. The results of the study did not reveal statistically significant changes in the density of GFAP-IR cells in E1 and E2 groups of rats in comparison with group C. A statistically significant increase in the density of S100β-IR astrocytes was observed in the E1 group and a decrease in the E2 group. Astrocytes with expression of both studied proteins were characterised by morphological alterations in ARC in the E2 group. The obtained results suggest an influence of CAP contained in habanero pepper fruits on the reactivity of astroglia, which may have an impact on the astrocyte-neuron interactions in order to maintain a proper activity of nervous cells in ARC.

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“…Jego interakcje z GFAP oddziałują na cykl komórkowy, wzrost i różnicowa-nie astrocytów (1). Dodatkowo S-100β może być wydzielane do przestrzeni zewnątrzkomórkowej na skutek pobudzenia receptorów metabotropowych dla glutaminianu z grupy II (mGluR3), co wykazano w hipokampie myszy w modelu epilepsji (28). W przestrzeni zewnątrzkomórkowej S-100β moduluje wychwyt Glu przez astrocyty (31).…”

Section: Wyniki I Omówienieunclassified

Influence of the age of rats treated with the sodium salt of glutamate acid on the reactivity of astroglia of the infundibular nucleus

Krawczyk¹,

Jaworska-Adamu²

2017

Medycyna Weterynaryjna

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The aim of the study was the immunohistochemical evaluation of the impact of the age of animals treated with the sodium salt of glutamic acid on the behaviour of astrocytes of the infundibular nucleus (IN). Immunohistochemical peroxidase-antiperoxidase reactions were conducted on brain sections of 10-day-old (I) and 63-day-old (II) rats treated s.c with monosodium glutamate (MSG) in a dose of 4g/kg b.w. for three consecutive days. The staining was performed using specific antibodies against glial fibrillary acidic protein (GFAP), S-100β protein and Ki-67 antigen. Cells immunopositive for the proteins under investigation were assessed morphologically and morphometrically in an Olympus BX51 light microscope with the Cell ^ D program. Statistically significant differences were tested using ANOVA and the non-parametric Kruskal-Wallis test. In the infundibular nucleus of 10-day-old rats treated with MSG, there was an increase in the number of GFAP, S-100β and Ki-67 immunopositive astrocytes without any changes in their morphology, which was typical of immature glia. In adult rats treated with MSG, a decrease in the number of cells expressing GFAP and S-100β was found. Most astrocytes had thick and weakly branched processes, in contrast to those observed in control animals. The results of our study showed a diverse behaviour of astroglia of IN in young and adult rats treated with MSG. In 10-day-old rats, hyperplasia of glia occurred, whereas in 63-day-old individuals there was a loss and hypertrophy of astrocytes, which may indicate a late stage of their reactivity. This information may contribute to targeting the therapy of diseases of the nervous system induced by the excitotoxic effects of glutamate.

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Neural-Activity-Dependent Release of S100B from Astrocytes Enhances Kainate-Induced Gamma OscillationsIn Vivo

Cited by 100 publications

References 62 publications

An astrocyte-dependent mechanism for neuronal rhythmogenesis

An astrocyte-dependent mechanism for neuronal rhythmogenesis

Immunoreactivity of arcuate nucleus astrocytes in rats after intragastric administration of habanero peppers (Capsicum Chinese Jacq.)

Influence of the age of rats treated with the sodium salt of glutamate acid on the reactivity of astroglia of the infundibular nucleus

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